Profiles of Adjustment among Children in Institutional Care in Ghana: Predictors of Positive Functioning

Worldwide, approximately 2-8 million children reside in institutional care, which can lead to developmental setbacks. Given the need for institutional care persists, it is important to continue investigating which improvements can be made to provide optimal care. The current mixed-methods study included participants from Accra, Ghana. Study 1 involved cluster analyses to determine patterns of adjustment for 100 children in institutional care (CIC) (M age = 13.31 years, SD = 3.14; 40% female) and 100 children in families (CIF) (M age = 13.37 years, SD = 3.08; 40% female) across several domains. ANOVA was used to evaluate whether protective factors differentiated between patterns. Findings were compared between the CIC and CIF. Study 2 used qualitative interviews with 38 Ghanaian teachers and institutional staff (M age = 43.31 years, SD = 10.37; 82% female) to gather adult perceptions of youth adjustment and interpretations of Study 1 results. Results revealed multiple patterns functioning for CIC and CIF. It was determined that three groups of CIC met the definition of resilience one or more areas of functioning. For CIC, problem-solving coping varied between clusters, while for CIF self-efficacy and adaptability varied significantly. Study 2 participants largely affirmed the quantitative findings, noting that children may struggle some areas while having strengths in others. Having basic needs met, a stable home, and a high level of adult support were the most common factors believed to contribute to positive functioning. Participants explained why problem-solving coping was significant for CIC. Intervention implications and future directions were discussed

Identifying Profiles of Resilience among a High-Risk Adolescent Population

The purpose of the present study was to determine whether distinct patterns of adolescent adjustment existed when four domains of functioning were considered. The study included a sample of 299 high-risk urban adolescents, predominantly African American, ages 9-16 and their maternal caregivers. Cluster analysis was used to identify patterns of adjustment. Logistic regression analyses were used to explore whether variations in levels of five theoretically and empirically supported protective factors predicted cluster membership. A four-cluster model was determined to best fit the data. Higher rates of goal directedness and anger regulation coping predicted membership within the highest functioning cluster over a cluster demonstrating high externalizing problem behaviors, and neighborhood cohesion predicted highest functioning cluster membership over a cluster demonstrating high internalizing symptoms. Findings suggest that within a high-risk population of adolescents, significant variability in functioning will exist. The presence or absence of specific protective factors predicts developmental outcomes

A surprisingly simple electrostatic model explains bent vs. linear structures in M+-RG2 species (M = group 1 metal, Li–Fr; RG = rare gas, He–Rn)

It is found that a simple electrostatic model involving competition between the attractive dispersive interaction and induced-dipole repulsion between the two RG atoms performs extremely well in rationalizing the M+-RG2 geometries, where M = Group 1 metal and RG = rare gas. The Li+-RG2 and Na+-RG2 complexes have previously been found to exhibit quasilinear or linear minimum energy geometries, with the Na+-RG2 complexes having an additional bent local minimum [A. Andrejeva, A. M. Gardner, J. B. Graneek, R. J. Plowright, W. H. Breckenridge and T. G. Wright, J. Phys. Chem. A, 2013, 117, 13578]. In the present work, the geometries for M = K–Fr are found to be bent. A simple electrostatic model explains these conclusions and is able to account almost quantitatively for the binding energy of the second RG atom, as well as the form of the angular potential, for all thirty six titular species. Additionally, results of population analyses are presented together with orbital contour plots; combined with the success of the electrostatic model, the expectation that these complexes are all physically bound is confirmed

Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.

Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV, whereas TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

BACKGROUND: Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock. METHODS AND DESIGN: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1.5 g), thiamine (100 mg), and hydrocortisone (50 mg) given every 6 h for up to 16 doses in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis. The primary outcome is ventilator- and vasopressor-free days with mortality as the key secondary outcome. Recruitment began in August 2018 and is ongoing; 501 participants have been enrolled to date, with a planned maximum sample size of 2000. The Data and Safety Monitoring Board reviewed interim results at N = 200, 300, 400 and 500, and has recommended continuing recruitment. The next interim analysis will occur when N = 1000. This update presents the statistical analysis plan. Specifically, we provide definitions for key treatment and outcome variables, and for intent-to-treat, per-protocol, and safety analysis datasets. We describe the planned descriptive analyses, the main analysis of the primary end point, our approach to secondary and exploratory analyses, and handling of missing data. Our goal is to provide enough detail that our approach could be replicated by an independent study group, thereby enhancing the transparency of the study. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03509350. Registered on 26 April 2018

Effects of the stellar wind on X-ray spectra of Cygnus X-3

We study X-ray spectra of Cyg X-3 from BeppoSAX, taking into account absorption and emission in the strong stellar wind of its companion. We find the intrinsic X-ray spectra are well modelled by disc blackbody emission, its upscattering by hot electrons with a hybrid distribution, and by Compton reflection. These spectra are strongly modified by absorption and reprocessing in the stellar wind, which we model using the photoionization code cloudy. The form of the observed spectra implies the wind is composed of two phases. A hot tenuous plasma containing most of the wind mass is required to account for the observed features of very strongly ionized Fe. Small dense cool clumps filling <0.01 of the volume are required to absorb the soft X-ray excess, which is emitted by the hot phase but not present in the data. The total mass-loss rate is found to be (0.6--1.6) x 10^-5 solar masses per year. We also discuss the feasibility of the continuum model dominated by Compton reflection, which we find to best describe our data. The intrinsic luminosities of our models suggest that the compact object is a black hole.Comment: MNRAS, in pres

From cook to chef: Facilitating the transition from recipe-driven to open-ended research-based undergraduate chemistry lab activities

This paper describes the development of mini-research projects in the third year practical chemistry course at the University of Nottingham for the MSci(Hons) Chemistry degree. The aim of these developments is to bridge the gap between ‘recipe-style’ experiments in the first and second year courses and research projects undertaken in the fourth year or in industry. There is much evidence that, having been given this opportunity to plan and design their own experiment, students exhibit higher-order cognitive skills, which can lead to a more valuable learning experience