973 research outputs found

    Physical Dissipation and the Method of Controlled Lagrangians

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    We describe the effect of physical dissipation on stability of equilibria which have been stabilized, in the absence of damping, using the method of controlled Lagrangians. This method applies to a class of underactuated mechanical systems including “balance” systems such as the pendulum on a cart. Since the method involves modifying a system’s kinetic energy metric through feedback, the effect of dissipation is obscured. In particular, it is not generally true that damping makes a feedback-stabilized equilibrium asymptotically stable. Damping in the unactuated directions does tend to enhance stability, however damping in the controlled directions must be “reversed” through feedback. In this paper, we suggest a choice of feedback dissipation to locally exponentially stabilize a class of controlled Lagrangian systems

    Dissipation and Controlled Euler-Poincaré Systems

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    The method of controlled Lagrangians is a technique for stabilizing underactuated mechanical systems which involves modifying a system’s energy and dynamic structure through feedback. These modifications can obscure the effect of physical dissipation in the closed-loop. For example, generic damping can destabilize an equilibrium which is closed-loop stable for a conservative system model. In this paper, we consider the effect of damping on Euler-PoincarĂ© (special reduced Lagrangian) systems which have been stabilized about an equilibrium using the method of controlled Lagrangians. We describe a choice of feed-back dissipation which asymptotically stabilizes a sub-class of controlled Euler-PoincarĂ© systems subject to physical damping. As an example, we consider intermediate axis rotation of a damped rigid body with a single internal rotor

    Microreview Cell signalling and Trypanosoma cruzi invasion

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    Summary Mammalian cell invasion by the protozoan pathogen Trypanosoma cruzi is critical to its survival in the host. To promote its entry into a wide variety of nonprofessional phagocytic cells, infective trypomastigotes exploit an arsenal of heterogenous surface glycoproteins, secreted proteases and signalling agonists to actively manipulate multiple host cell signalling pathways. Signals initiated in the parasite upon contact with mammalian cells also function as critical regulators of the invasion process. Whereas the full spectrum of cellular responses modulated by T. cruzi is not yet known, mounting evidence suggests that these pathways impinge on a number of cellular processes, in particular the ubiquitous wound-repair mechanism exploited for lysosomemediated parasite entry. Furthermore, differential engagement of host cell signalling pathways in a cell type-specific manner and modulation of host cell gene expression by T. cruzi are becoming recognized as essential determinants of infectivity and intracellular survival by this pathogen

    The effect of grading the atomic number at resistive guide element interface on magnetic collimation

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    Using 3 dimensional numerical simulations, this paper shows that grading the atomic number and thus the resistivity at the interface between an embedded high atomic number guide element and a lower atomic number substrate enhances the growth of a resistive magnetic field. This can lead to a large integrated magnetic flux density, which is fundamental to confining higher energy fast electrons. This results in significant improvements in both magnetic collimation and fast-electron-temperature uniformity across the guiding. The graded interface target provides a method for resistive guiding that is tolerant to laser pointing

    Psoas Abscess in Inflammatory Bowel Disease

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72133/1/j.1572-0241.1985.tb02023.x.pd
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