293 research outputs found
Pattern production through a chiral chasing mechanism
Recent experiments on zebrafish pigmentation suggests that their typical black and white striped skin pattern is made up of a number of interacting chromatophore families. Specifically, two of these cell families have been shown to interact through a nonlocal chasing mechanism, which has previously been modeled using integro-differential equations. We extend this framework to include the experimentally observed fact that the cells often exhibit chiral movement, in that the cells chase, and run away, at angles different to the line connecting their centers. This framework is simplified through the use of multiple small limits leading to a coupled set of partial differential equations which are amenable to Fourier analysis. This analysis results in the production of dispersion relations and necessary conditions for a patterning instability to occur. Beyond the theoretical development and the production of new pattern planiforms we are able to corroborate the experimental hypothesis that the global pigmentation patterns can be dependent on the chirality of the chromatophores
Graph-Facilitated Resonant Mode Counting in Stochastic Interaction Networks
Oscillations in a stochastic dynamical system, whose deterministic
counterpart has a stable steady state, are a widely reported phenomenon.
Traditional methods of finding parameter regimes for stochastically-driven
resonances are, however, cumbersome for any but the smallest networks. In this
letter we show by example of the Brusselator how to use real root counting
algorithms and graph theoretic tools to efficiently determine the number of
resonant modes and parameter ranges for stochastic oscillations. We argue that
stochastic resonance is a network property by showing that resonant modes only
depend on the squared Jacobian matrix , unlike deterministic oscillations
which are determined by . By using graph theoretic tools, analysis of
stochastic behaviour for larger networks is simplified and chemical reaction
networks with multiple resonant modes can be identified easily.Comment: 5 pages, 4 figure
Likely equilibria of stochastic hyperelastic spherical shells and tubes
In large deformations, internally pressurised elastic spherical shells and
tubes may undergo a limit-point, or inflation, instability manifested by a
rapid transition in which their radii suddenly increase. The possible existence
of such an instability depends on the material constitutive model. Here, we
revisit this problem in the context of stochastic incompressible hyperelastic
materials, and ask the question: what is the probability distribution of stable
radially symmetric inflation, such that the internal pressure always increases
as the radial stretch increases? For the classic elastic problem, involving
isotropic incompressible materials, there is a critical parameter value that
strictly separates the cases where inflation instability can occur or not. By
contrast, for the stochastic problem, we show that the inherent variability of
the probabilistic parameters implies that there is always competition between
the two cases. To illustrate this, we draw on published experimental data for
rubber, and derive the probability distribution of the corresponding random
shear modulus to predict the inflation responses for a spherical shell and a
cylindrical tube made of a material characterised by this parameter.Comment: arXiv admin note: text overlap with arXiv:1808.0126
Likely oscillatory motions of stochastic hyperelastic solids
Stochastic homogeneous hyperelastic solids are characterised by strain-energy
densities where the parameters are random variables defined by probability
density functions. These models allow for the propagation of uncertainties from
input data to output quantities of interest. To investigate the effect of
probabilistic parameters on predicted mechanical responses, we study radial
oscillations of cylindrical and spherical shells of stochastic incompressible
isotropic hyperelastic material, formulated as quasi-equilibrated motions where
the system is in equilibrium at every time instant. Additionally, we study
finite shear oscillations of a cuboid, which are not quasi-equilibrated. We
find that, for hyperelastic bodies of stochastic neo-Hookean or Mooney-Rivlin
material, the amplitude and period of the oscillations follow probability
distributions that can be characterised. Further, for cylindrical tubes and
spherical shells, when an impulse surface traction is applied, there is a
parameter interval where the oscillatory and non-oscillatory motions compete,
in the sense that both have a chance to occur with a given probability. We
refer to the dynamic evolution of these elastic systems, which exhibit inherent
uncertainties due to the material properties, as `likely oscillatory motions'
Random blebbing motion: a simple model linking cell structural properties to migration characteristics
If the plasma membrane of a cell is able to delaminate locally from its actin cortex a cellular bleb can be produced. Blebs are pressure driven protrusions, which are noteworthy for their ability to produce cellular motion. Starting from a general continuum mechanics description we restrict ourselves to considering cell and bleb shapes that maintain approximately spherical forms. From this assumption we obtain a tractable algebraic system for bleb formation. By including cell-substrate adhesions we can model blebbing cell motility. Further, by considering mechanically isolated blebbing events, which are randomly distributed over the cell we can derive equations linking the macroscopic migration characteristics to the microscopic structural parameters of the cell. This multiscale modelling framework is then used to provide parameter estimates, which are in agreement with current experimental data. In summary the construction of the mathematical model provides testable relationships between the bleb size and cell motility
Likely equilibria of the stochastic Rivlin cube
The problem of the Rivlin cube is to determine the stability of all homogeneous equilibria of an isotropic incompressible hyperelastic body under equitriaxial dead loads. Here, we consider the stochastic version of this problem where the elastic parameters are random variables following standard probability laws. Uncertainties in these parameters may arise, for example, from inherent data variation between different batches of homogeneous samples, or from different experimental tests. As for the purely elastic problem, we consider the following questions: what are the likely equilibria and how does their stability depend on the material constitutive law? In addition, for the stochastic model, the problem is to derive the probability distribution of deformations, given the variability of the parameters
Modelling polarity-driven laminar patterns in bilayer tissues with mixed signalling mechanisms
Recent advances in high-resolution experimental methods have highlighted the
significance of cell signal pathway crosstalk and localised signalling activity
in the development and disease of numerous biological systems. The
investigation of multiple signal pathways often introduces different methods of
cell-cell communication, i.e. contact-based or diffusive signalling, which
generates both a spatial and temporal dependence on cell behaviours. Motivated
by cellular mechanisms that control cell-fate decisions in developing bilayer
tissues, we use dynamical systems coupled with multilayer graphs to analyse the
role of signalling polarity and pathway crosstalk in fine-grain pattern
formation of protein activity. Specifically, we study how multilayer graph edge
structures and weights influence the layer-wise (laminar) patterning of cells
in bilayer structures, which are commonly found in glandular tissues. We
present sufficient conditions for existence, uniqueness and instability of
homogeneous cell states in the large-scale spatially discrete dynamical system.
Using methods of pattern templating by graph partitioning to generate quotient
systems in combination with concepts from monotone dynamical systems, we
exploit the extensive dimensionality reduction to provide existence conditions
for the polarity required to induce fine-grain laminar patterns with multiple
spatially dependent intracellular components. We then explore the spectral
links between the quotient and large-scale dynamical systems to extend the
laminar patterning criteria from existence to convergence for sufficiently
large amounts of cellular polarity in the large-scale dynamical system,
independent of spatial dimension and number of cells in the tissue
Heterogeneity induces spatiotemporal oscillations in reaction-diffusions systems
We report on a novel instability arising in activator-inhibitor reaction-diffusion (RD) systems with a simple spatial heterogeneity. This instability gives rise to periodic creation, translation, and destruction of spike solutions that are commonly formed due to Turing instabilities. While this behavior is oscillatory in nature, it occurs purely within the Turing space such that no region of the domain would give rise to a Hopf bifurcation for the homogeneous equilibrium. We use the shadow limit of the Gierer-Meinhardt system to show that the speed of spike movement can be predicted from well-known asymptotic theory, but that this theory is unable to explain the emergence of these spatiotemporal oscillations. Instead, we numerically explore this system and show that the oscillatory behavior is caused by the destabilization of a steady spike pattern due to the creation of a new spike arising from endogeneous activator production. We demonstrate that on the edge of this instability, the period of the oscillations goes to infinity, although it does not fit the profile of any well known bifurcation of a limit cycle. We show that nearby stationary states are either Turing unstable, or undergo saddle-node bifurcations near the onset of the oscillatory instability, suggesting that the periodic motion does not emerge from a local equilibrium. We demonstrate the robustness of this spatiotemporal oscillation by exploring small localized heterogeneity, and showing that this behavior also occurs in the Schnakenberg RD model. Our results suggest that this phenomenon is ubiquitous in spatially heterogeneous RD systems, but that current tools, such as stability of spike solutions and shadow-limit asymptotics, do not elucidate understanding. This opens several avenues for further mathematical analysis and highlights difficulties in explaining how robust patterning emerges from Turing's mechanism in the presence of even small spatial heterogeneity
Temporary public spaces: A technological paradigm
Contemporary cities no longer offer the same types of permanent environments that we planned for in the latter part of the twentieth century. Our public spaces are increasingly temporary, transient, and ephemeral. The theories, principles and tactics with which we designed these spaces in the past are no longer appropriate. We need a new theory for understanding the creation, use, and reuse of temporary public space. Moe than a theory, we need new architectural tactics or strategies that can be reliably employed to create successful temporary public spaces.
This paper will present ongoing research that starts that process through critical review and technical analysis of existing and historic temporary public spaces. Through the analysis of a number of public spaces, that were either designed for temporary use or became temporary through changing social conditions, this research identifies the tactics and heuristics used in such projects. These tactics and heuristics are then analysed to extract some broader principles for the design of temporary public space. The theories of time related building layers, a model of environmental sustainability, and the recycling of social meaning, are all explored.
The paper will go on to identify a number of key questions that need to be explored and addressed by a theory for such developments: How can we retain social meaning in the fabric of the city and its public spaces while we disassemble it and recycle it into new purposes? What role will preservation have in the rapidly changing future; will exemplary temporary spaces be preserved and thereby become no longer temporary? Does the environmental advantage of recycling materials, components and spaces outweigh the removal or social loss of temporary public space? This research starts to identify the knowledge gaps and proposes a number of strategies for making public space in the age of temporary, recyclable, and repurposing of our urban infrastructure; a way of creating lighter, cheaper, quicker, and temporary interventions
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