779 research outputs found
Relationships Between Sulcal Asymmetries and Corpus Callosum Size: Gender and Handedness Effects
Magnetic resonance imaging was used to establish the presence and nature of relationships between sulcal asymmetries and mid-sagittal callosal size in neurologically intact subjects, and to determine the influences of sex and handedness. Against a background of long-standing disputes, effects of gender and handedness on callosal size, shape, and variability were additionally examined. Both positive and negative correlations between sulcal asymmetry and callosal size were observed, with effects influenced by sex and handedness. The direction of relationships, however, were dependent on the regional asymmetry measured and on whether real or absolute values were used to quantify sulcal asymmetries. Callosal measurements showed no significant effects of sex or handedness, although subtle differences in callosal shape were observed in anterior and posterior regions between males and females and surface variability was increased in males. Individual variations in callosal size appear to outrange any detectable divergences in size between groups. Relationships between sulcal asymmetries and callosal size, however, are influenced by both sex and handedness. Whether magnitudes of asymmetry are related to increases or decreases in callosal size appears dependent on the chosen indicators of asymmetry. It is an oversimplification, therefore, to assume a single relationship exists between cerebral asymmetries and callosal connection
Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment
Pulmonary alveolar microlithiasis (PAM) is a rare, autosomal recessive lung disorder associated with progressive accumulation of calcium phosphate microliths. Inactivating mutations in SLC34A2, which encodes the NPT2b sodiumdependent phosphate cotransporter, has been proposed as a cause of PAM.Weshow that epithelial deletion ofNpt2b in mice results in a progressive pulmonary process characterized by diffuse alveolar microlith accumulation, radiographic opacification, restrictive physiology, inflammation, fibrosis, and an unexpected alveolar phospholipidosis. Cytokine and surfactant protein elevations in the alveolar lavage and serum of PAM mice and confirmed in serum from PAM patients identify serum MCP-1 (monocyte chemotactic protein 1) and SP-D (surfactant protein D) as potential biomarkers.Microliths introduced by adoptive transfer into the lungs of wild-typemice produce markedmacrophagerich inflammation and elevation of serum MCP-1 that peaks at 1 week and resolves at 1 month, concomitant with clearance of stones. Microliths isolated by bronchoalveolar lavage readily dissolve in EDTA, and therapeutic wholelung EDTA lavage reduces the burden of stones in the lungs. A low-phosphate diet prevents microlith formation in young animals and reduces lung injury on the basis of reduction in serum SP-D. The burden of pulmonary calcium deposits in established PAM is also diminished within 4 weeks by a low-phosphate diet challenge. These data support a causative role for Npt2b in the pathogenesis of PAM and the use of the PAMmouse model as a preclinical platform for the development of biomarkers and therapeutic strategies
Role of dynamical particle-vibration coupling in reconciliation of the puzzle for spherical proton emitters
It has been observed that decay rate for proton emission from
single particle state is systematically quenched compared with the prediction
of a one dimensional potential model although the same model successfully
accounts for measured decay rates from and states. We
reconcile this discrepancy by solving coupled-channels equations, taking into
account couplings between the proton motion and vibrational excitations of a
daughter nucleus. We apply the formalism to proton emitting nuclei
Re to show that there is a certain range of parameter set of the
excitation energy and the dynamical deformation parameter for the quadrupole
phonon excitation which reproduces simultaneously the experimental decay rates
from the 2, 3 and 1 states in these nuclei.Comment: RevTex, 12 pages, 4 eps figure
Imaging Spectroscopy of a White-Light Solar Flare
We report observations of a white-light solar flare (SOL2010-06-12T00:57,
M2.0) observed by the Helioseismic Magnetic Imager (HMI) on the Solar Dynamics
Observatory (SDO) and the Reuven Ramaty High-Energy Solar Spectroscopic Imager
(RHESSI). The HMI data give us the first space-based high-resolution imaging
spectroscopy of a white-light flare, including continuum, Doppler, and magnetic
signatures for the photospheric FeI line at 6173.34{\AA} and its neighboring
continuum. In the impulsive phase of the flare, a bright white-light kernel
appears in each of the two magnetic footpoints. When the flare occurred, the
spectral coverage of the HMI filtergrams (six equidistant samples spanning
\pm172m{\AA} around nominal line center) encompassed the line core and the blue
continuum sufficiently far from the core to eliminate significant Doppler
crosstalk in the latter, which is otherwise a possibility for the extreme
conditions in a white-light flare. RHESSI obtained complete hard X-ray and
\Upsilon-ray spectra (this was the first \Upsilon-ray flare of Cycle 24). The
FeI line appears to be shifted to the blue during the flare but does not go
into emission; the contrast is nearly constant across the line profile. We did
not detect a seismic wave from this event. The HMI data suggest stepwise
changes of the line-of-sight magnetic field in the white-light footpoints.Comment: 14 pages, 7 figures, Accepted by Solar Physic
A Model for the Stray Light Contamination of the UVCS Instrument on SOHO
We present a detailed model of stray-light suppression in the spectrometer
channels of the Ultraviolet Coronagraph Spectrometer (UVCS) on the SOHO
spacecraft. The control of diffracted and scattered stray light from the bright
solar disk is one of the most important tasks of a coronagraph. We compute the
fractions of light that diffract past the UVCS external occulter and
non-specularly pass into the spectrometer slit. The diffracted component of the
stray light depends on the finite aperture of the primary mirror and on its
figure. The amount of non-specular scattering depends mainly on the
micro-roughness of the mirror. For reasonable choices of these quantities, the
modeled stray-light fraction agrees well with measurements of stray light made
both in the laboratory and during the UVCS mission. The models were constructed
for the bright H I Lyman alpha emission line, but they are applicable to other
spectral lines as well.Comment: 19 pages, 5 figures, Solar Physics, in pres
Svestka's Research: Then and Now
Zdenek Svestka's research work influenced many fields of solar physics,
especially in the area of flare research. In this article I take five of the
areas that particularly interested him and assess them in a "then and now"
style. His insights in each case were quite sound, although of course in the
modern era we have learned things that he could not readily have envisioned.
His own views about his research life have been published recently in this
journal, to which he contributed so much, and his memoir contains much
additional scientific and personal information (Svestka, 2010).Comment: Invited review for "Solar and Stellar Flares," a conference in honour
of Prof. Zden\v{e}k \v{S}vestka, Prague, June 23-27, 2014. This is a
contribution to a Topical Issue in Solar Physics, based on the presentations
at this meeting (Editors Lyndsay Fletcher and Petr Heinzel
Theoretical description of deformed proton emitters: nonadiabatic coupled-channel method
The newly developed nonadiabatic method based on the coupled-channel
Schroedinger equation with Gamow states is used to study the phenomenon of
proton radioactivity. The new method, adopting the weak coupling regime of the
particle-plus-rotor model, allows for the inclusion of excitations in the
daughter nucleus. This can lead to rather different predictions for lifetimes
and branching ratios as compared to the standard adiabatic approximation
corresponding to the strong coupling scheme. Calculations are performed for
several experimentally seen, non-spherical nuclei beyond the proton dripline.
By comparing theory and experiment, we are able to characterize the angular
momentum content of the observed narrow resonance.Comment: 12 pages including 10 figure
Does high-dose metformin cause lactic acidosis in type 2 diabetic patients after CABG surgery? A double blind randomized clinical trial
Metformin is a dimethyl biguanide oral anti-hyperglycemic agent. Lactic acidosis due to metformin is a fatal metabolic condition that limits its use in patients in poor clinical condition, consequently reducing the number of patients who benefit from this medication. In a double blind randomized clinical trial, we investigated 200 type 2 diabetic patients after coronary artery bypass surgery in the open heart ICU of the Mazandaran Heart Center, and randomly assigned them to equal intervention and control groups. The intervention group received regular insulin infusion along with 2 metformin 500 mg tablets every twelve hours, while the control group received only intravenous insulin with 2 placebo tablets every twelve hours. Lactate level, pH, base excess, blood glucose and serum creatinine were measured over five 12 h periods, with data averaged for each period. The primary outcome in this study was high lactate levels. Comparison between the 2 groups was made by independent Student’s t-test. To compare changes in multiple measures in each group and analysis of group interaction, a repeated measurement ANOVA test was used
Extreme Ultra-Violet Spectroscopy of the Lower Solar Atmosphere During Solar Flares
The extreme ultraviolet portion of the solar spectrum contains a wealth of
diagnostic tools for probing the lower solar atmosphere in response to an
injection of energy, particularly during the impulsive phase of solar flares.
These include temperature and density sensitive line ratios, Doppler shifted
emission lines and nonthermal broadening, abundance measurements, differential
emission measure profiles, and continuum temperatures and energetics, among
others. In this paper I shall review some of the advances made in recent years
using these techniques, focusing primarily on studies that have utilized data
from Hinode/EIS and SDO/EVE, while also providing some historical background
and a summary of future spectroscopic instrumentation.Comment: 34 pages, 8 figures. Submitted to Solar Physics as part of the
Topical Issue on Solar and Stellar Flare
Strength of the 18F(p, α)15O resonance at Ec.m. = 330 keV
The astrophysical rate of the 18F(p,α)15O reaction at nova temperatures is critical to understanding production of the radioisotope 18F, which may be used to constrain nova models via observations with the coming generation of satellite-based γ-ray telescopes. As such, a measurement is made of the strength of this resonance using a radioactive 18F beam at the HRIBF. As a result, it is indicated that the 18F(p,α)15O reaction rate is lower than previous estimates by a factor of ∼2
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