Mildred Arkell. I.

Dialecto literario. -- Worcestershire. -- Pertenece a la colección LD 1800-1950 del Salamanca Corpus. -- Mrs. Henry Wood, 1814-1887. -- Ellen Price, 1814-1887. -- Mildred Arkell, vol. 1. -- 1865.[ES]Novela que se desarrolla en Worcestershire y que contiene dialecto de Worcestershire. [EN]Novel that takes place in Worcestershire and which contains Worcestershire dialect

A Life's Secret. Vol. 2

Dialecto literario. -- Worcestershire. -- Pertenece a la colección LD 1800-1950 del Salamanca Corpus. -- Mrs. Henry Wood, 1814-1887. -- Ellen Price, 1814-1887. -- A Life's Secret, Vol 2. -- 1867.[ES]Novela que se desarrolla en Worcestershire y que contiene dialecto de Worcestershire. [EN]Novel that takes place in Worcestershire and contains Worcestershire dialect

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Mrs Halliburton’s Troubles. Vol. 2.

Dialecto literario. -- Worcestershire. -- Pertenece a la colección LD 1800-1950 del Salamanca Corpus. -- Mrs. Henry Wood, 1814-1887. -- Ellen Price, 1814-1887. -- Mrs. Halliburton's Troubles, Vol. 1. -- 1862.[ES]Novela que se desarrolla en Worcestershire y que contiene dialecto de Worcestershire. [EN]Novel that takes place in Worcestershire and contains Worcestershire dialect

Danesbury House

Dialecto literario. -- Worcestershire. -- Pertenece a la colección LD 1800-1950 del Salamanca Corpus. -- Mrs. Henry Wood, 1814-1887. -- Ellen Price, 1814-1887. -- Danesbury House. -- 1860.[ES]Novela que se desarrolla en Worcestershire y que contiene dialecto de Worcestershire. [EN]Novel that takes place in Worcestershire and contains Worcestershire dialect

The story of Charles Strange, a novel.

Mode of access: Internet

East Lynne; a drama in five acts, adapted from the famous novel of that name,

Mode of access: Internet

East Lynne

Poster for East Lynne ; Lady Isabel Carlyle, a beautiful and refined young woman, leaves her hard-working but neglectful lawyer-husband and her infant children to elope with an aristocratic suitor. After he deserts her, and she bears their illegitimate child, Lady Isabel disguises herself and takes the position of governess in the household of her husband and his new wif