Evaluation of the Effectiveness of Regranex (Becaplermin) Gel 0.01% on the Treatment of Wounds

REGRANEX (becaplermin[rhPDGF-BB]) Gel 0.01% is a topical gel used for the treatment of chronic lower extremity diabetic neuropathic ulcers (8 weeks or longer). It contains growth factors to aid in healing by promoting the formation of granulation tissue. Becaplermin[rhPDGF-BB] is the only growth factor to show clinical efficacy and to be approved by the FDA. The purpose of this study is to evaluate the effectiveness of this topical gel to speed the closing of wounds and/or production of healthy granulation tissue. To accomplish this evaluation, a chart review was done at Altru Health Systems. A list of names of patients who have been treated at the wound clinic was attained and a chart review was done on the basis of this list. Eight patient charts, 4 of which received REGRANEX and 4 that did not receive REGRANEX were reviewed. Objective data collected from the charts included: length, width and depth of the wound, percent granulation tissue, location, cleansing and dressing of the wound. A statistical analysis was performed to determine if REGRANEX was an effective wound topical gel. This study demonstrated REGRANEX is associated with less eschar and therefore more granulation tissue when viewed by the clinician. However, no significant difference was found with statistical analysis. Improvement in the formation of granulation tissue is a plus for patients with diabetes because it may prevent them from enduring the pain or other side effects that go along with debridement

The State of Mental Health on College Campuses

In the past twenty years, the number of college students with clinical depression and suicidal tendencies has tripled, and approximately 1.6 million students sought counseling assistance last year. It is perhaps no wonder that acts of violence on campuses have increased as well. This article examines what administrators can do in order to protect our colleges from further tragic occurrences

A psychological analysis of the effects of memory retrieval prior to extinction on the reacquisition of a conditioned fear association

The successful reduction of fear is the aim of clinicians treating people with anxiety disorders such as post-traumatic stress disorder or phobias. Existing treatments for these conditions, however, require many treatment sessions and are prone to relapse. A new technique, first demonstrated in rats by Monfils, Cowansage, Klann, & LeDoux (2009) and later shown to be effective in humans (Schiller et al., 2010), provides a method of efficiently reducing fear in a manner which is resistant to various known triggers of relapse. This procedure involves a single presentation of the fear-inducing stimulus one hour prior to extinction training. This procedure produces extinction learning that is resistant to the return of fear resulting from a change of context, the passage of time, exposure to the unconditioned stimulus, and even further conditioning of the stimulus with an aversive stimulus. This dissertation focuses on one particular property of this procedure: that a stimulus extinguished using this procedure is resistant to subsequent retraining of the fear association. The first four experiments presented here are aimed at replicating this phenomenon and determining whether prediction error at retrieval is necessary for the effect to occur. Following on from these studies, the next chapter presents three experiments which investigate whether trial spacing effects could explain the enhanced extinction and highlights conditions under which the effect is weakened, or possibly reversed. The next three experiments compare the properties of a stimulus extinguished under these conditions with a stimulus extinguished under normal conditions. These studies focus on explanations involving inhibition, inattention and the disruption of stimulus representations. In the final three experiments, the possibility of reversing the effect is investigated. These studies look at the effect of memory retrieval prior to retraining of the stimulus to determine the conditions under which the stimulus can again come to elicit a fear response.Medical Research Council Programme Grant; Overseas Research Studentship; Poynton Cambridge Commonwealth Trust; Oon Khye Beng Ch‟hia Tsio Bursar

The effects of caffeine on ratings of perceived exertion and completion times in a 1.5-mile run test in college-aged males.

The purpose of this study was to examine the effects of caffeine from Red Bull on selected aspects of running performance during a 1.5 mile run test in college-aged males--Abstract, leaf x.

Working with external partners to support climate change education through a focus on design

In this paper we reflect on the opportunities and potential pitfalls encountered when schools work in partnership with external organisations. To illustrate wider issues, we examine the implementation of a pilot project aimed at introducing the role of design in the context of climate change in the primary setting. Our data comprise observational field notes of activities in situ, interviews with participating teachers, focus groups with children, and interviews with designers who led the activities across five different schools in England. In reviewing the data, we highlight the need for partners to build upon each other’s skills, genuinely co‐creating activities and co‐leading lessons. Most importantly, we call for all climate change initiatives to be grounded in children’s realities and provide ample opportunities for children to be agentic

Science Communication Portfolio

Document describes the theory and practice of verbal and written science communication strategies, and provides an example portfolio on the topic of sea level rise.Are you working on a research manuscript, grant, annual report, or project summary that requires technical language? Do you feel that your finding, if communicated properly, could be useful to people beyond your professional network? This communication-training document for scientists is designed to help you do just that – on your own time and for a variety of verbal and written communication styles. We also provide an example portfolio on the topic of sea level rise for reference.Center for Microbial Oceanography: Research and Education (NSF #0424599, Wood-Charlson); Union of Concerned Scientists (Varga