Oxyresveratrol mitigates cellular toxicity in an in-vitro and in-vivo model of Parkinson's disease

C02.g. Therapeutic Targets, Mechanisms for Treatment: Anti-inflammatory, anti-oxidant - no. ADPD7-0264Aims: The role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been greatly demonstrated as a pathological phenomenon in Parkinson’s disease (PD). These signalling mechanisms are activated when there is an increased burden of misfolded proteins in neurons, primarily alpha synuclein, in the case of PD. In this study we aim to elucidate the effects of oxyresveratrol, a potent antioxidant, on the UPR in PD. Furthermore, the neuro-protective potential of oxyresveratrol in an in-vivo model was tested. Method: The murine dopaminergic Mes 23.5 cell line was treated with the parkinsonian mimetic 6-hydroxydopamine (6-OHDA). Effects of oxyresveratrol on the downstream effectors mediating the UPR were investigated by immunoblotting and quantitative PCR. For the in-vivo model, male Sprague-Dawley rats were injected stereotactically with 6-OHDA. Subsequently, immunohistochemistry to study midbrain pathology and behaviour tests to assess motor debilitation, were performed. Results: Oxyresveratrol reduced the expression of ATF4 and CHOP, following induction of ER stress in the Mes 23.5 cells by 6-OHDA. The activation of this branch of the UPR, downstream of PERK, propels the cell towards apoptosis. Motor dysfunction was also alleviated in the oxyresveratrol-treated rats, along with a partial preservation of dopaminergic cells in the substantia nigra pars compacta. Conclusion: This study suggests that attenuation of apoptosis driven by the UPR may be an important mechanism of action of oxyresveratrol. Moreover, a protection of motor function and cell loss seen in the in vivo model suggests that oxyresveratrol may be a useful therapeutic candidate for PD

The effect of sevoflurane in cognition

Conference Theme: Science and Aging: An Era of discover

The effect of sevoflurane in cognitive and synaptic function

Abstracts from AAIC 2016 will be published in a future issue of Alzheimer's & Dementia: The Journal of the Alzheimer's Associatio

An interactive web-based sexual health literacy program for safe sex practice for female Chinese university students : multicenter randomized controlled trial

202109 bcvcVersion of RecordPublishe

A música como recurso no cuidado à criança hospitalizada: uma intervenção possível? La musica como recurso en el cuidado al niño hospitalizado: una intervención possible? Musica as a resource in care for hospitalized children: a possible intervention?

Trata-se de um estudo bibliográfico realizado a partir das bases de dados MEDLINE e LILACS e vias não-sistematizadas, no período de 1994 a 2004. Teve como objetivo analisar a produção bibliográfica da enfermagem pediátrica quanto à utilização da música como recurso terapêutico no espaço hospitalar, a fim de identificar o estado do conhecimento desta área nesse campo. Da análise do material empírico, emergiram três unidades de significados: o cenário, as intervenções e as repercussões. Os resultados evidenciaram os benefícios da música para a criança hospitalizada, seus familiares e equipe de saúde e constatou-se que este recurso pode ser utilizado no espaço hospitalar como uma intervenção de baixo custo, não-farmacológica e não-invasiva, promovendo um processo de desenvolvimento que visa à saúde da criança, da família e dos trabalhadores.<br>Se trata de un estudio bibliográfico realizado a partir de bases de datos MEDLINE, LILACS y vías no sistematizadas que comprendió el período de 1994 al 2004. Tiene como objetivo analizar la producción bibliográfica relacionada a enfermería pediátrica la música con el fin de identificar el estado del conocimiento en ese campo. Del análisis del material empírico, surgieron tres unidades de significado: el escenario, las intervenciones y las repercusiones. Los resultados evidenciaron los beneficios de la música para el niño hospitalizado, sus familiares y equipo de salud. Verificamos que la música puede ser utilizada en los hospitales como una intervención de bajo costo, no farmacológica y no invasiva, promoviendo los procesos de desarrollo, visualizando la salud del niño, de la familia y de los trabajadores.<br>This bibliographic study involved the Medline and LILACS databases as well as non-systematized searches and covered the period from 1994 to 2004. We aimed to analyze the bibliographic production on pediatric nursing and music, in order to identify current knowledge in this area. Our analysis revealed 3 units of meaning: the setting, interventions and repercussions. The results disclose the benefits music can offer to hospitalized children, their family members and health teams. We observed that music can be used in hospitals as a low-cost, nonpharmacological and noninvasive intervention, promoting development processes with a view to the health of children, families and workers