Dangerous women of Hong Kong? Media construction of stigma in female sex workers

This study used a cultural model analysis to examine the Hong Kong print media’s social construction of stigma in respect to female sex workers. An analysis was conducted on captions and main headlines of two newspaper (Chinese and English) median in Hong Kong, 2003-2006. A total of 591 articles on sex workers were recruited in the analysis with 422 located from the Ming Pao and 169 articles the SCMP. A total of Sixty seven articles on health issues were identified. In Hong Kong, as in elsewhere, sex workers were commonly labeled as the sources of sexually transmitted diseases and as women who endangered the public safety through socially unacceptable occupations. They were also portrayed as “ugly”, “weak” and “powerless” in the articles identified. We conclude the Hong Kong print media plays a significant role in contributing to the stigmatization of sex workers, heightening health risk and vulnerability. Such social construction of public stigma then in turn, can be argued to contribute to a lessened propensity for female sex workers both seek and engage with formal health services.published_or_final_versio

Incidence of femoracetabular impingement at-risk radiographic parameters in asymptomatic young Chinese and Whites: a computerised tomogram study

Conference Theme: Defying the Aging Spine: Our Mission ContinuesConcurrent Free Papers 5 - Sports: no. 5.16INTRODUCTION: Femoroacetabular impingement (FAI) is uncommon in Chinese when compared with Whites. It has been postulated that this is due to a difference in hip joint osteometry. However, there is no study comparing FAI at-risk radiographic signs between the 2 populations. METHODS: A total of 201 subjects (99 Whites and 102 Chinese) scheduled for computed tomogram of pelvis for non–orthopaedic-related diagnosis were …postprin

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges.

Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could be achieved. The route of entry of Mycobacterium tuberculosis, the causative organism, is via inhalation making TB primarily a respiratory disease. There is therefore good reason to hypothesize that a mucosally delivered vaccine against TB could be more effective than one delivered via the systemic route.Areas covered: This review summarizes the progress that has been made in the area of TB mucosal vaccines in the last few years. It highlights some of the strengths and shortcomings of the published evidence and aims to discuss immunological and practical considerations in the development of mucosal vaccines.Expert opinion: There is a growing body of evidence that the mucosal approach to vaccination against TB is feasible and should be pursued. However, further key studies are necessary to both improve our understanding of the protective immune mechanisms operating in the mucosa and the technical aspects of aerosolized delivery, before such a vaccine could become a feasible, deployable strategy

Energy-Efficient Heterogeneous Cellular Networks with Spectrum Underlay and Overlay Access

IEEE In this paper, we provide joint subcarrier assignment and power allocation schemes for quality-of-service (QoS)-constrained energy-efficiency (EE) optimization in the downlink of an orthogonal frequency division multiple access (OFDMA)-based two-tier heterogeneous cellular network (HCN). Considering underlay transmission, where spectrum-efficiency (SE) is fully exploited, the EE solution involves tackling a complex mixed-combinatorial and non-convex optimization problem. With appropriate decomposition of the original problem and leveraging on the quasi-concavity of the EE function, we propose a dual-layer resource allocation approach and provide a complete solution using difference-of-two-concave-functions approximation, successive convex approximation and gradient-search method. On the other hand, the inherent inter-tier interference from spectrum underlay access may degrade EE particularly under dense small-cell deployment and large bandwidth utilization. We therefore develop a novel resource allocation approach based on the concepts of spectrum overlay access and resource efficiency (RE) (normalized EE-SE trade-off). Specifically, the optimization procedure is separated where the macro-cell optimal RE and the corresponding bandwidth is first determined, then the EE of small-cells utilizing the remaining spectrum is maximized. Simulation results confirm the theoretical findings and demonstrate that the proposed resource allocation schemes can approach the optimal EE with each strategy being superior under certain system settings

Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis

Background: Tuberculosis (TB) chemotherapy clears bacterial burden in the lungs of patients and allows the tuberculous lesions to heal through a fibrotic process. The healing process leaves pulmonary scar tissue that can impair lung function. The goal of this study was to identify fibrotic mediators as a stepping-stone to begin exploring mechanisms of tissue repair in TB. Methods: Hematoxylin and eosin staining and Masson's trichrome stain were utilized to determine levels of collagenization in tuberculous granulomas from non-human primates. Immunohistochemistry was then employed to further interrogate these granulomas for markers associated with fibrogenesis, including transforming growth factor-β (TGFβ), α-smooth muscle actin (αSMA), phosphorylated SMAD-2/3, and CD163. These markers were compared across states of drug treatment using one-way ANOVA, and Pearson's test was used to determine the association of these markers with one another. Results: TGFβ and αSMA were present in granulomas from primates with active TB disease. These molecules were reduced in abundance after TB chemotherapy. Phosphorylated SMAD-2/3, a signaling intermediate of TGFβ, was observed in greater amounts after 1 month of drug treatment than in active disease, suggesting that this particular pathway is blocked in active disease. Collagen production during tissue repair is strongly associated with TGFβ in this model, but not with CD163+ macrophages. Conclusions: Tissue repair and fibrosis in TB that occurs during drug treatment is associated with active TGFβ that is produced during active disease. Further work will identify mechanisms of fibrosis and work towards mitigating lung impairment with treatments that target those mechanisms

Learning from the severe acute respiratory syndrome (SARS) epidemic

Author name used in this publication: Joanne W. Y. Chung2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Prevalence of Femoroacetabular Impingement “at-risk” Radiographic Parameters in Young Asymptomatic Chinese and Caucasian Subjects

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An evaluation of nursing practice models in the context of the severe acute respiratory syndrome epidemic in Hong Kong : a preliminary study

Author name used in this publication: Joanne W. Y. Chung2006-2007 > Academic research: refereed > Publication in refereed journalAuthor’s OriginalPublishe

Protection of islet grafts through transforming growth factor-beta-induced tolerogenic dendritic cells

In type 1 diabetes, the insulin-producing β-cells are destroyed by the immune system. One way of restoring glucose control is to transplant β-cells from a donor. Although this procedure may restore endogenous insulin production, immunosuppressive treatment is needed to prevent the recipient from rejecting the donor-derived islets. We investigated the possibilities of transient expression of the immunosuppressive cytokine transforming growth factor (TGF)-β within islets to achieve long-term graft tolerance. We found that brief expression of TGF-β prevented rejection of syngeneic islets, that there was reduction of dendritic cell (DC) activation in the graft, and that there was reduced reactivation of T cells in the graft-draining lymph nodes. In vitro exposure of bone marrow–derived DCs to TGF-β reduced expression of costimulatory molecules CD80 and CD86, as well as production of proinflammatory cytokines such as interleukin-12 p70 in DCs, but did not alter levels of major histocompatibility complex classes I and II. Furthermore, the capacity of TGF-β–treated bone marrow–derived DCs to activate both CD4+ and CD8+ T cells was reduced. Adding TGF-β–conditioned tolerogenic DCs to the grafted islets led to long-term survival of the graft, demonstrating that TGF-β–induced tolerogenic DCs can provide an effective means to restore immune tolerance in an already established autoimmune disease

Application of a virtual reality prototype for pain relief of pediatric burn in Taiwan

Author name used in this publication: Joanne W. Y. Chung2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe