The Construction and Related Industries in a Changing Socio-Economic Environment: The Case of Hong Kong

Hong Kong is well known for its “housing market bubble”. Both theoretical and empirical studies point to the supply side being the “root of all evil”. This paper takes a preliminary step in understanding the supply side of the Hong Kong market by investigating the construction and related industries. After taking into consideration of the unusual public expenditure, the construction industry seems to be “normal” in international standard. Its relationship with the aggregate economy is also examined. Directions for future research are also suggested.housing, construction, government policy, employment, investment

Optimal Mass Configurations for Lensing High-Redshift Galaxies

We investigate the gravitational lensing properties of lines of sight containing multiple cluster-scale halos, motivated by their ability to lens very high-redshift (z ~ 10) sources into detectability. We control for the total mass along the line of sight, isolating the effects of distributing the mass among multiple halos and of varying the physical properties of the halos. Our results show that multiple-halo lines of sight can increase the magnified source-plane region compared to the single cluster lenses typically targeted for lensing studies, and thus are generally better fields for detecting very high-redshift sources. The configurations that result in optimal lensing cross sections benefit from interactions between the lens potentials of the halos when they overlap somewhat on the sky, creating regions of high magnification in the source plane not present when the halos are considered individually. The effect of these interactions on the lensing cross section can even be comparable to changing the total mass of the lens from 10^15 M_sun to 3x10^15 M_sun. The gain in lensing cross section increases as the mass is split into more halos, provided that the lens potentials are projected close enough to interact with each other. A nonzero projected halo angular separation, equal halo mass ratio, and high projected halo concentration are the best mass configurations, whereas projected halo ellipticity, halo triaxiality, and the relative orientations of the halos are less important. Such high mass, multiple-halo lines of sight exist in the SDSS.Comment: Accepted for publication in ApJ; emulateapj format; 24 pages, 13 figures, 1 table; plots updated to reflect erratu

In vivo imaging of protease activity by Probody therapeutic activation.

Probody™ therapeutics are recombinant, proteolytically-activated antibody prodrugs, engineered to remain inert until activated locally by tumor-associated proteases. Probody therapeutics exploit the fundamental dysregulation of extracellular protease activity that exists in tumors relative to healthy tissue. Leveraging the ability of a Probody therapeutic to bind its target at the site of disease after proteolytic cleavage, we developed a novel method for profiling protease activity in living animals. Using NIR optical imaging, we demonstrated that a non-labeled anti-EGFR Probody therapeutic can become activated and compete for binding to tumor cells in vivo with a labeled anti-EGFR monoclonal antibody. Furthermore, by inhibiting matriptase activity in vivo with a blocking-matriptase antibody, we show that the ability of the Probody therapeutic to bind EGFR in vivo was dependent on protease activity. These results demonstrate that in vivo imaging of Probody therapeutic activation can be used for screening and characterization of protease activity in living animals, and provide a method that avoids some of the limitations of prior methods. This approach can improve our understanding of the activity of proteases in disease models and help to develop efficient strategies for cancer diagnosis and treatment

Troponin T Gene Switching Is Developmentally Regulated by Plasma-Borne Factors in Parabiotic Chicks

AbstractMyogenesis involves a conserved program of muscle gene isoform switching requiring the synchronized induction and repression of numerous muscle-specific gene family members. Central to understanding the regulation of this process are questions related to the origin and transmission of regulatory signals to the myofiber. We show here that troponin T gene switching can be precociously initiated by extrinsic blood-borne components but also requires other mechanisms that are regulated locally, intrinsically, or posttranscriptionally. We established a chimeric blood circulation by parabiosis between fetal chicks and quails to determine whether signals inducing earlier troponin T mRNA isoform switching in quails could be transduced to chick partners through the serum. While quail fetuses were unaffected by parabiosis, quail serum caused premature troponin T iso-mRNA switching in chick muscle, although initiation remained later than in quails. The onset of repression of a known innervation-dependent acetylcholine receptor mRNA did not coincide with the initiation of troponin T iso-mRNA switching and was not affected by parabiosis. These results support serum-borne factor regulation of isoform switching as an important and distinct mechanism relevant to understanding how extrinsic and intrinsic cues are integrated during muscle differentiation and development

Aggregation of Fine Particles at the Sediment-Water Interface

The presence of a bottom sediment layer agitated by mechanical stirring or by resident organisma (tubificid oligochaetes) significantly increases the rate at which fine (1 µm) cohesive particles are removed from suspension in laboratory columns. Measured rates of particle removal are equivalent to deposition velocities ranging from 0.23 m per day to 0.41 m per day. These rates are an order of magnitude faster than deposition by gravitational settling or coagulation with larger particles in the water column as observed in experimental controls. It is hypothesized that the increased removal rate is the result of aggregation in a sediment layer at the bed-water interface characterized by loosely bound (fluffy), porous material hydrodynamically coupled to the water column. According to this hypothesis particle removal occurs when motion of the overlying water or organism activity causes suspended fine particles to collide with and stick to the interfacial sediment. This new hypothesis is supported by the mass and size distribution of tracer particles recovered in cores and sediment traps at a coastal site and by theoretical estimates of interfacial aggregation rates.This work was supported by EPA grant CR-81181-01-01, by the MIT Sea Grant College Program, under NOAA Grant NA86AA-D-SG089, and by a postgraduate scholarship awarded to the second author by the Natural Sciences and Engineering Research Council of Canada.https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/92JC0182

Joint Strong and Weak Lensing Analysis of the Massive Cluster Field J0850+3604

We present a combined strong and weak lensing analysis of the J085007.6+360428 (J0850) field, which was selected by its high projected concentration of luminous red galaxies and contains the massive cluster Zwicky 1953. Using Subaru/Suprime-Cam $BVR_{c}I_{c}i^{\prime}z^{\prime}$ imaging and MMT/Hectospec spectroscopy, we first perform a weak lensing shear analysis to constrain the mass distribution in this field, including the cluster at $z = 0.3774$ and a smaller foreground halo at $z = 0.2713$. We then add a strong lensing constraint from a multiply-imaged galaxy in the imaging data with a photometric redshift of $z \approx 5.03$. Unlike previous cluster-scale lens analyses, our technique accounts for the full three-dimensional mass structure in the beam, including galaxies along the line of sight. In contrast with past cluster analyses that use only lensed image positions as constraints, we use the full surface brightness distribution of the images. This method predicts that the source galaxy crosses a lensing caustic such that one image is a highly-magnified "fold arc", which could be used to probe the source galaxy's structure at ultra-high spatial resolution ($< 30$ pc). We calculate the mass of the primary cluster to be $\mathrm{M_{vir}} = 2.93_{-0.65}^{+0.71} \times 10^{15}~\mathrm{M_{\odot}}$ with a concentration of $\mathrm{c_{vir}} = 3.46_{-0.59}^{+0.70}$, consistent with the mass-concentration relation of massive clusters at a similar redshift. The large mass of this cluster makes J0850 an excellent field for leveraging lensing magnification to search for high-redshift galaxies, competitive with and complementary to that of well-studied clusters such as the HST Frontier Fields.Comment: Accepted for publication in The Astrophysical Journal; 14 pages, 13 figures, 3 table

Characterization of slow and fast phase nystagmus

A current literature review of the analog and digital process of vestibular and optical kinetic nystagmus reveals little agreement in the methods used by various labs. The strategies for detection of saccade (fast phase velocity component of nystagmus) vary between labs, and most of the process have not been evaluated and validated with a standard database. A survey was made of major vestibular labs in the U.S. that perform computer analyses of vestibular and optokinetic reflexes to stimuli, and a baseline was established from which to standardize data acquisition and analysis programs. The concept of an Error Index was employed as the criterium for evaluating the performance of the vestibular analysis software programs. The performance criterium is based on the detection of saccades and is the average of the percentages of missed detections and false detections. Evaluation of the programs produced results for lateral gaze with saccadic amplitude of one, two, three, five, and ten degrees with various signal-to-noise ratios. In addition, results were obtained for sinusoidal pursuit of 0.05, 0.10, and 0.50 Hz with saccades from one to ten degrees at various signal-to-noise ratios. Selection of the best program was made from the performance in the lateral gaze with three degrees of saccadic amplitude and in the 0.10 Hz sinusoid with three degrees of saccadic amplitude

J/Psi Propagation in Hadronic Matter

We study J/$\psi$ propagation in hot hadronic matter using a four-flavor chiral Lagrangian to model the dynamics and using QCD sum rules to model the finite size effects manifested in vertex interactions through form factors. Charmonium breakup due to scattering with light mesons is the primary impediment to continued propagation. Breakup rates introduce nontrivial temperature and momentum dependence into the J/$\psi$ spectral function.Comment: 6 Pages LaTeX, 3 postscript figures. Proceedings for Strangeness in Quark Matter 2003, Atlantic Beach, NC, March 12-17, 2003; minor corrections in version 2, to appear in J. Phys.

Observation of metastable Aβ amyloid protofibrils by atomic force microscopy

AbstractBackground: Brain amyloid plaque, a diagnostic feature of Alzheimer's disease (AD), contains an insoluble fibrillar core that is composed primarily of variants of the β-amyloid protein (Aβ). As Aβ amyloid fibrils may initiate neurodegeneration, the inhibition of fibril formation is a possible therapeutic strategy. Very little is known about the early steps of the process, however.Results: Atomic force microscopy was used to follow amyloid fibril formation in vitro by the Aβ variants Aβ1-40 and Aβ1-42. Both variants first form small ordered aggregates that grow slowly and then rapidly disappear, while prototypical amyloid fibrils of two discrete morphologies appear. Aβ1-42 aggregates much more rapidly than Aβ1-40, which is consistent with its connection to early-onset AD. We propose that the metastable intermediate species be called Aβ amyloid protofibrils.Conclusions: Aβ protofibrils are likely to be intermediates in the in vitro assembly of Aβ amyloid fibrils, but their in vivo role has yet to be determined. Numerous reports of a nonfibrillar form of Aβ aggregate in the brains of individuals who are predisposed to AD suggest the existence of a precursor form, possibly the protofibril. Thus, stabilization of Aβ protofibrils may be a useful therapeutic strategy