5,213 research outputs found
On Relational Injustice: Could Colonialism Have Been Wrong Even if it Had Introduced More Benefits than Harms?
A certain objection to the view that colonialism is and was morally problematic is that it has introduced more benefits than harms to the populations that have undergone it. This article sets aside the empirical question – that is, of interrogating whether colonialism did bring more benefits than harms; instead, it argues that historical instances of colonialism were wrong even if they had in fact brought net-positive aggregate consequences to the colonised populations. In arguing this, I develop and substantiate a new concept of relational injustice in describing the unique nature of inegalitarian, subjugative relationship defining the interaction between perpetrators and victims in colonialism. Given that moral relations cannot be reduced into the welfare of their respective individual agents, it is hence the case that incidental, unintended gains in individual welfare neither adequately compensate for nor at all rectify the initial relational injustice. There are three objections that are discussed and rejected, such as: i) the purported irrationality in individuals regretting events that left them better-off on aggregate, ii) individuals can opt to waive being in just and equal relations with others in exchange for individual gains, and iii) the advanced account is self-defeating, because it nullifies the possibility for adequate compensation
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Comparing Outcomes Between the Over-the-Top and All-Epiphyseal Techniques for Physeal-Sparing ACL Reconstruction: A Narrative Review.
A variety of techniques are used for physeal-sparing anterior cruciate ligament (ACL) reconstruction; however, there is no clear consensus on the ideal surgical technique, the frequency of complications, and how to best avoid growth disturbance. The purpose of this study was to compare outcomes and complications between over-the-top and all-epiphyseal ACL reconstruction techniques. The hypothesis was that both physeal-sparing reconstruction techniques are efficacious, with similar risk of growth disturbance and complications. The Embase and PubMed databases were queried for studies on ACL ruptures in the skeletally immature population from 1985 to 2018. Full-text English studies were included (N = 160). Studies reporting rerupture and/or complications after physeal-sparing ACL reconstruction, specifically growth disturbance, were included (n = 10). Studies were separated into 2 groups: an all-epiphyseal group with femoral and tibial fixation points within the epiphysis and a group that had over-the-top femoral and tibial physeal-sparing reconstruction. Complications not specific to the pediatric population were excluded. Demographics, evaluation of skeletal maturity, surgical technique, growth disturbance, rerupture, and patient-reported outcome scores were collected. Data were analyzed in aggregate. The 10 studies included 482 knees. The mean age was 12.0 years; 81% of patients were male; and mean follow-up was 47.7 months. A total of 178 patients underwent all-epiphyseal reconstruction, and 298 had the femoral graft placed over the top. The rerupture rate was 9.0% (16 of 178) in the all-epiphyseal group and 7.2% (14 of 195) in the over-the-top group, of which 82% required revision reconstruction. Six patients had overgrowth in the all-epiphyseal group (mean, 1.8 cm) and 1 patient in the over-the-top group (1.5 cm). Three angular deformities occurred, all of which were in the over-the-top group. Both physeal-sparing ACL reconstruction techniques are successful. Overgrowth was more common in the all-epiphyseal group and angular deformity in the over-the-top group. Rerupture rates were similar between the groups. The authors recommend standardization of skeletal age assessment and baseline lower extremity alignment films
Residual negative symptoms differentiate cognitive performance in clinically stable patients with schizophrenia and bipolar disorder
Cognitive deficits in various domains have been shown in patients with bipolar disorder and schizophrenia. The purpose of the present study was to examine if residual psychopathology explained the difference in cognitive function between clinically stable patients with schizophrenia and bipolar disorder. We compared the performance on tests of attention, visual and verbal memory and executive function of 25 patients with schizophrenia in remission and 25 euthymic bipolar disorder patients with that of 25 healthy controls. Mediation analysis was used to see if residual psychopathology could explain the difference in cognitive function between the patient groups.
Both patient groups performed significantly worse than healthy controls on most cognitive tests. Patients with bipolar disorder displayed cognitive deficits that were milder but qualitatively similar to those of patients with schizophrenia. Residual negative symptoms mediated the difference in performance on cognitive tests between the two groups. Neither residual general psychotic symptoms nor greater antipsychotic doses explained this relationship. The shared variance explained by the residual negative and cognitive deficits that the difference between patient groups may be explained by greater frontal cortical neurophysiological deficits in patients with schizophrenia, compared to bipolar disorder. Further longitudinal work may provide insight into pathophysiological mechanisms that underlie these deficits
Remarks on mod-ln Representations, l=3, 5
AbstractLet l=3 or 5. For any integer n>1, we produce an infinite set of triples (L, E1, E2), where L is a number field with degree l3(n−1) over Q and E1 and E2 are elliptic curves over L with distinct j-invariants lying in Q, such that the following conditions hold: (1) the pairs of j-invariants {j(E1), j(E2)} are mutually disjoint, (2) the associated mod-ln representations GL=Gal(L/L)→GL2(Z/ln) are surjective, (3) for almost all primes p of L, we have ln∣ap(E1) if and only if ln∣ap(E2), and (4) the two representations Ei[ln](L) are not related by twisting by a continuous character GL→(Z/ln)×. No such triple satisfying (2)–(4) exists over any number field if we replace l by a prime larger than 5. The proof depends on determining the automorphisms of the group GL2(Z/ln) for l=3, 5 and analyzing ramification in a branched covering of “twisted” modular curves
Automatic Classification of Human Epithelial Type 2 Cell Indirect Immunofluorescence Images using Cell Pyramid Matching
This paper describes a novel system for automatic classification of images
obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial
type 2 (HEp-2) cells using the Indirect Immunofluorescence (IIF) protocol. The
IIF protocol on HEp-2 cells has been the hallmark method to identify the
presence of ANAs, due to its high sensitivity and the large range of antigens
that can be detected. However, it suffers from numerous shortcomings, such as
being subjective as well as time and labour intensive. Computer Aided
Diagnostic (CAD) systems have been developed to address these problems, which
automatically classify a HEp-2 cell image into one of its known patterns (eg.
speckled, homogeneous). Most of the existing CAD systems use handpicked
features to represent a HEp-2 cell image, which may only work in limited
scenarios. We propose a novel automatic cell image classification method termed
Cell Pyramid Matching (CPM), which is comprised of regional histograms of
visual words coupled with the Multiple Kernel Learning framework. We present a
study of several variations of generating histograms and show the efficacy of
the system on two publicly available datasets: the ICPR HEp-2 cell
classification contest dataset and the SNPHEp-2 dataset.Comment: arXiv admin note: substantial text overlap with arXiv:1304.126
A cost-utility analysis for prophylactic central neck dissection in clinically nodal-negative papillary thyroid carcinoma
Background: Although prophylactic central neck dissection (pCND) may reduce future locoregional recurrence after total thyroidectomy (TT) for low-risk papillary thyroid carcinoma (PTC), it is associated with a higher initial morbidity. We aimed to compare the long-term cost-effectiveness between TT with pCND (TT+pCND) and TT alone in the institution's perspective. Methods: Our case definition was a hypothetical cohort of 100,000 nonpregnant female patients aged 50 years with a 1.5-cm cN0 PTC within one lobe. A Markov decision tree model was constructed to compare the estimated cost-effectiveness between TT+pCND and TT alone after a 20-year period. Outcome probabilities, utilities, and costs were estimated from the literature. The threshold for cost-effectiveness was set at US34.52 but gained an additional 0.323 QALY. In fact, in the sensitivity analysis, TT+pCND became cost-effective 9 years after the initial operation. In the threshold analysis, none of the scenarios that could change this conclusion appeared clinically possible or likely. However, TT+pCND became cost-saving (i.e., less costly and more cost-effective) at 20 years if associated permanent vocal cord palsy was kept ≤1.37 %, permanent hypoparathyroidism was ≤1.20 %, and/or postoperative radioiodine ablation use was ≤73.64 %. Conclusions: In the institution's perspective, routine pCND for low-risk PTC began to become cost-effective 9 years after initial surgery and became cost-saving at 20 years if postoperative radioiodine use and/or permanent surgical complications were kept to a minimum. © 2013 Society of Surgical Oncology.postprin
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Comparison of PREDICTS atherosclerosis biomarker changes after initiation of new treatments in patients with SLE
Objective Patients with SLE have an increased risk ofatherosclerosis (ATH) that is not adequately explainedby traditional risk factors. We previously described thePredictors of Risk for Elevated Flares, Damage Progression,and Increased Cardiovascular disease in PaTients withSLE (PREDICTS) atherosclerosis-risk panel, which includesproinflammatory HDL (piHDL), leptin, soluble tumournecrosis factor-like weak inducer of apoptosis (sTWEAK)and homocysteine, as well as age and diabetes. A highPREDICTS score confers 28-fold increased odds forfuture atherosclerosis in SLE. The aim of this study is todetermine whether PREDICTS biomarkers are modifiable bycommon lupus therapies.Methods This prospective observational study includedSLE subjects started on new lupus treatments. Leptin,sTWEAK, homocysteine and antioxidant function of HDLwere measured at baseline (prior to drug initiation), 6weeks and 12 weeks.Results 16 subjects started mycophenolate (MMF), 18azathioprine (AZA) and 25 hydroxychloroquine (HCQ).In MMF-treated subjects, HDL function progressivelyimproved from 2.23 ± 1.32 at baseline to 1.37±0.81at 6 weeks (p=0.02) and 0.93±0.54 at 12 weeks(p=0.009). sTWEAK levels also improved in MMF-treatedsubjects from 477.5±447.1 to 290.3±204.6 pg/mLafter 12 weeks (p=0.04), but leptin and homocysteinelevels were not significantly changed. In HCQ-treatedsubjects, only HDL function improved from 1.80±1.29 atbaseline to 1.03±0.74 after 12 weeks (p=0.05). Therewere no changes in the AZA group. MMF treatmentwas still associated with significant improvements inHDL function after accounting for potential confounderssuch as total prednisone dose and changes in diseaseactivity. Overall, the mean number of high-risk PREDICTSbiomarkers at week 12 significantly decreased in theentire group of patients started on a new lupus therapy(2.1±0.9 to 1.8±0.9, p=0.02) and in the MMF-treatedgroup (2.4±0.8 vs 1.8±0.9, p=0.003), but not in theAZA or HCQ groups. In multivariate analysis, the odds ofhaving a high PREDICTS atherosclerosis risk score at 12weeks were lower with MMF treatment (OR 0.002, 95%CI 0.000 to 0.55, p=0.03).Conclusions 12 weeks of MMF therapy improves theoverall PREDICTS atherosclerosis biomarker profile.Further studies will determine whether biomarkerchanges reflect decreases in future cardiovascularevents
Methods for evaluating changes in cartilage stiffness following electromechanical reshaping
One common component of otolaryngological surgeries is the reshaping of cartilage. Previous studies have demonstrated the efficient achievement of this procedure through electromechanical reshaping (EMR), a technique that involves the direct application of voltage to cartilage that is mechanically deformed in a jig. Two main parameters, voltage and application time, may be regulated to achieve varying degrees of shape change. Although prior research has correlated these EMR parameters with degree of shape change, it remains necessary to correlate the same parameters with the degree of change in the mechanical properties of tissue. Once this is accomplished, an ideal balance may be determined, in which shape change is maximized while intrinsic tissue damage is minimized This study satisfies this need by providing comprehensive data on the pre- and post-EMR stiffness of both septal and auricular cartilage over a range of voltages (2-8V) with constant application time (2 min for septal, 3 min for auricular). EMR was applied using flat platinum electrodes to one of two 15 mm X 5 mm samples obtained from the same cartilage specimen, while the second sample was maintained as a control. Following a 15 min re-hydration period, the Young's modulus of the tissue was calculated for both the control and experimental sample from data obtained through a uniaxial tension test. A general reduction in stiffness was observed beginning at 3V, with the magnitude of reduction increasing at 6V. © 2010 Copyright SPIE - The International Society for Optical Engineering
Stable Isotopic Tracing—A Way Forward for Nanotechnology
Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic tracers, which have been used widely in the earth sciences and in metabolic and other health-related studies for several decades, could be used to address many of these issues. One such example we are pursuing is the use of stable isotopes to monitor dermal absorption of zinc and titanium oxides in sunscreen preparations and other personal care products. Other potential applications of this tracing approach are discussed
Robotic Fingerspelling Hand for Deaf-Blind Communication
Robotic fingerspelling hand for the deaf-blind. The hand forms the shapes of the American Manual Alphabet with 11 servos. The project was sponsored by The Smith-Kettlewell Eye Reaserch Institute
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