CPR and ECC

This practical workshop will demonstrate the following Emergency and Critaickl Care techiques: Cardioplumonary Resuscitation. Thoracocentesis. Intermittent Positive Pressure Ventilation. Delegates will then be provided with the opportunity to practice the techniques themeselves on professional mannequins

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction

p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 expression or activity are associated with the development of cancer and several related neurodegenerative disorders. Although pathogenic p97 mutations cluster in and around p97's ATPase domains, mutant proteins display normal or elevated ATPase activity. Here, we show that one of the most common p97 mutations (R155C) retains ATPase activity, but is functionally defective. p97-R155C can be recruited to ubiquitinated substrates on chromatin, but is unable to promote substrate removal. As a result, p97-R155C acts as a dominant negative, blocking protein extraction by a similar mechanism to that observed when p97's ATPase activity is inhibited or inactivated. However, unlike ATPase-deficient proteins, p97-R155C consumes excess ATP, which can hinder high-energy processes. Together, our results shed new insight into how pathogenic mutations in p97 alter its cellular function, with implications for understanding the etiology and treatment of p97-associated diseases

Water resources, agriculture and the environment.

In this article, water utilization by individuals and especially agricultural systems is analyzed. Interrelationships exist among population growth, water use and distribution, the status of biodiversity, the natural environment, plus the impacts of water borne human diseases are reported

A Candidate Brightest Proto-Cluster Galaxy at z = 3.03

We report the discovery of a very bright (m_R = 22.2) Lyman break galaxy at z = 3.03 that appears to be a massive system in a late stage of merging. Deep imaging reveals multiple peaks in the brightness profile with angular separations of ~0.''8 (~25 h^-1 kpc comoving). In addition, high signal-to-noise ratio rest-frame UV spectroscopy shows evidence for ~5 components based on stellar photospheric and ISM absorption lines with a velocity dispersion of sigma ~460 km s^-1 for the three strongest components. Both the dynamics and high luminosity, as well as our analysis of a LCDM numerical simulation, suggest a very massive system with halo mass M ~ 10^13 M_solar. The simulation finds that all halos at z = 3 of this mass contain sub-halos in agreement with the properties of these observed components and that such systems typically evolve into M ~ 10^14 M_solar halos in groups and clusters by z = 0. This discovery provides a rare opportunity to study the properties and individual components of z ~ 3 systems that are likely to be the progenitors to brightest cluster galaxies.Comment: 14 pages, 3 figures, submitted to ApJ Letter

Harm Reduction Developments 2008: Countries With Injection-Driven HIV Epidemics

Examines trends in HIV cases among injecting drug users in Eastern Europe and Central Asia, and outlines OSI and its partners' efforts to reduce drug-related harms fueling HIV epidemics. Includes country analyses and descriptions of prevention services

The Mob at Enfield: Introduction

For five days in May 1818, a mob set fear into the hearts of the Enfield, New Hampshire, Shakers. This little-known confrontation, provoked by two women whose husbands and children lived within the Enfield Shaker village, rallied public opinion against the Shakers and their way of life. The rare manuscript reprinted on the following pages records the Shakers’ account of the five-day mob, one of two lengthy Shaker recollections of this volatile event. Although written in the present tense, the document is retrospective and written after the conclusion of the mob, likely as part of the legal proceedings that followed

The therapist\u27s pregnancy and the client-therapist relationship : an exploratory study

This empirical research study explored the impact of the therapist\u27s pregnancy on the therapist-client relationship. Specifically, this study asked whether therapists and clients interact in less professional, more personal ways during the therapist\u27s pregnancy, and how this is perceived by therapists to impact treatment. Relational psychodynamic theory was the theoretical underpinning of this study. Thirteen psychotherapists were interviewed about their experiences of practicing therapy while pregnant. All participants were either currently or recently pregnant. Interview questions were developed by this researcher to elicit therapist experiences with clients who asked personal questions or offered baby gifts to the therapist, and how therapists felt about and responded to these behaviors. Interview questions also focused on how therapists perceived their pregnancy to impact the ways they conduct and understand therapy. Findings were that most therapists had some clients offer gifts and ask personal questions during and following their pregnancy, along with a range of other boundary-crossing behaviors. Therapists responded to these behaviors along a continuum, depending on the degree to which they felt comfortable and whether they experienced client behaviors as appropriate, intrusive, or threatening. In some cases, therapists felt the need to reaffirm professional boundaries, while in other cases, therapists felt the pregnancy offered an opportunity to interact with clients in a more personal, less professional manner, which was perceived by some to positively impact treatment

Artist Teacher

144 Pages This arts-based research project uses qualitative and autoethnographic methods to explore the concept of artist-teacher. The author/artist journaled for three months about her artmaking process while undertaking five discussions about her work with peer advisors, both of whom were practicing artists. The author discovered that that key themes that ran through her artmaking process included the use of found objects (chance and organization), intuition, metaphor, politics and spirituality, other artists’ influence, reflective practice, engagement with nature, and the effort to understand and address her audience. For three months, the author made notes about her teaching practice. These notes appeared to emphasize themes of chance, metaphor, other artists’ work, intuition, and reflection. The author discerned a connection between her activities as artist and as art teacher. Her artistic process shaped and gave agency to her arts pedagogy. Autoethnographic arts-based research helped to deepen both her artistic practice and teaching. Future recommendations would be to have other artist-teachers conduct their own arts-based research. The author intends to continue her own reflexive research throughout her teaching career. The author also recommends creating a collective group of artist-teachers to collaborate and reflect upon one another’s artwork and teaching