Adverse Childhood Experiences (ACEs):Policies and Practices for Prevention and Intervention

Programs and policies outlined below have been shown to address risk and protective factors for ACEs within family, relationship, community and social environments. They provide examples of cross-sector strategies that can contribute to increased child well-being in New Mexico by supporting stable, safe and nurturing relationships

A Guiding Vision for Fluid Learning: The Future of Education and Training

Position paper by the Digital Media Collaboratory (DMC) of the IC² Institute at The University of Texas at Austin. The authors envision learning systems as a ubiquitous public utility and propose an architecture to accomplish it. The paper includes a description of DMC research activities in 2003.IC2 Institut

Engaging men for a sexual violence-free nation: a cross-sectional study of U.S.-based organizations.

Presented at: American Public Health Association 2016 Annual Meeting & Expo; October 29-November 2, 2016; Denver, CO.https://digitalrepository.unm.edu/prc-posters-presentations/1024/thumbnail.jp

Mapping the incidence of rape reported to law enforcement in New Mexico and the availability of services to survivors.

Presented at: 2016 Annual Conference of the New Mexico Public Health Association; April 12-13, 2016; Las Cruces, NM.https://digitalrepository.unm.edu/prc-posters-presentations/1023/thumbnail.jp

EUVE J0425.6-5714: A Newly Discovered AM Herculis Star

We detected a new AM Her star serendipitously in a 25 day observation with the EUVE satellite. A coherent period of 85.82 min is present in the EUVE Deep Survey imager light curve of this source. A spectroscopic identification is made with a 19th magnitude blue star that has H and He emission lines, and broad cyclotron humps typical of a magnetic cataclysmic variable. A lower limit to the polar magnetic field of 46 MG is estimated from the spacing of the cyclotron harmonics. EUVE J0425.6-5714 is also detected in archival ROSAT HRI observations spanning two months, and its stable and highly structured light curve permits us to fit a coherent ephemeris linking the ROSAT and EUVE data over a 1.3 yr gap. The derived period is 85.82107 +/- 0.00020 min, and the ephemeris should be accurate to 0.1 cycles until the year 2005. A narrow but partial X-ray eclipse suggests that this object belongs to the group of Am Her stars whose viewing geometry is such that the accretion stream periodically occults the soft X-ray emitting accretion spot on the surface of the white dwarf. A non-detection of hard X-rays from ASCA observations that are contemporaneous with the ROSAT HRI shows that the soft X-rays must dominate by at least an order of magnitude, which is consistent with a known trend among AM Her stars with large magnetic field. This object should not be confused with the Seyfert galaxy 1H 0419-577 (= LB 1727), another X-ray/EUV source which lies only 4' away, and was the principal target of these monitoring observations.Comment: 13 pages, 5 figures, to appear in PASP, Dec. 1998 issu

Upregulated Glucose Metabolism Correlates Inversely with CD8(+) T-cell Infiltration and Survival in Squamous Cell Carcinoma

Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in infiltrating T cells contributing to differences in objective response rates. Here, we sought to understand the molecular correlates of tumor-infiltrating T lymphocytes (TIL) in squamous cell carcinoma (SCC), using a systems biologic approach to integrate publicly available omics datasets with histopathologic features. We provide evidence that links TIL abundance and therapeutic outcome to the regulation of tumor glycolysis by EGFR and HIF, both of which are attractive molecular targets for use in combination with immunotherapeutics

A study of women\u27s preferences regarding the formulation of over-the-counter vaginal spermicides

There is an urgent need for safe, effective, and acceptable vaginal barrier methods for the prevention of sexually transmitted diseases (STDs), including HIV, and a variety of existing spermicides have the potential to be used for both prevention of STDs and unwanted pregnancy. Unfortunately, very little is known about formulation preferences and the desirable characteristics of vaginal preparations among the diverse populations of women who would potentially use these products. In this study, we explored vaginal spermicidal preparations containing nonoxynol-9 and the characteristics that influence user preferences for three formulations, as well as the risk of vaginal and cervical irritation associated with low-to-moderate use of products containing nonoxynol-9. The report recommends that formulation preferences of women be considered in the development and introduction of vaginal microbicides: the specific characteristics of vaginal products and their effect on sexual pleasure and communication will strongly determine the acceptability—and ultimately the use-effectiveness—of female-controlled STD-prevention methods

The Three Dimensional Structure of EUV Accretion Regions in AM Herculis Stars: Modeling of EUV Photometric and Spectroscopic Observations

We have developed a model of the high-energy accretion region for magnetic cataclysmic variables and applied it to {\it Extreme Ultraviolet Explorer} observations of 10 AM Herculis type systems. The major features of the EUV light curves are well described by the model. The light curves exhibit a large variety of features such as eclipses of the accretion region by the secondary star and the accretion stream, and dips caused by material very close to the accretion region. While all the observed features of the light curves are highly dependent on viewing geometry, none of the light curves are consistent with a flat, circular accretion spot whose lightcurve would vary solely from projection effects. The accretion region immediately above the WD surface is a source of EUV radiation caused by either a vertical extent to the accretion spot, or Compton scattering off electrons in the accretion column, or, very likely, both. Our model yields spot sizes averaging 0.06 R$_{WD}$, or $f \sim 1 \times 10^{-3}$ the WD surface area, and average spot heights of 0.023 R$_{WD}$. Spectra extracted during broad dip phases are softer than spectra during the out-of-dip phases. This spectral ratio measurement leads to the conclusion that Compton scattering, some absorption by a warm absorber, geometric effects, an asymmetric temperature structure in the accretion region and an asymmetric density structure of the accretion columnare all important components needed to fully explain the data. Spectra extracted at phases where the accretion spot is hidden behind the limb of the WD, but with the accretion column immediately above the spot still visible, show no evidence of emission features characteristic of a hot plasma.Comment: 30 Pages, 11 Figure

The effect of two-temperature post-shock accretion flow on the linear polarization pulse in magnetic cataclysmic variables

The temperatures of electrons and ions in the post-shock accretion region of a magnetic cataclysmic variable (mCV) will be equal at sufficiently high mass flow rates or for sufficiently weak magnetic fields. At lower mass flow rates or in stronger magnetic fields, efficient cyclotron cooling will cool the electrons faster than the electrons can cool the ions and a two-temperature flow will result. Here we investigate the differences in polarized radiation expected from mCV post-shock accretion columns modeled with one- and two-temperature hydrodynamics. In an mCV model with one accretion region, a magnetic field >~30 MG and a specific mass flow rate of ~0.5 g/cm/cm/s, along with a relatively generic geometric orientation of the system, we find that in the ultraviolet either a single linear polarization pulse per binary orbit or two pulses per binary orbit can be expected, depending on the accretion column hydrodynamic structure (one- or two-temperature) modeled. Under conditions where the physical flow is two-temperature, one pulse per orbit is predicted from a single accretion region where a one-temperature model predicts two pulses. The intensity light curves show similar pulse behavior but there is very little difference between the circular polarization predictions of one- and two-temperature models. Such discrepancies indicate that it is important to model some aspect of two-temperature flow in indirect imaging procedures, like Stokes imaging, especially at the edges of extended accretion regions, were the specific mass flow is low, and especially for ultraviolet data.Comment: Accepted for publication in Astrophysics & Space Scienc