Gradient flow scale setting with tree-level improvement

Lattice scales defined using gradient flow are typically very precise, while also easy to calculate. However, different definitions of flows and operators can differ significantly, suggesting possible systematical effects. Using a subset of RBC-UKQCD's 2+1 flavor domain wall fermion and Iwasaki gauge action ensembles, we explore differences between $\sqrt{t_0}$ and $w_0$ gradient flow scales, compare the impact of different operators to define the energy density, and study the effect of using tree-level improvement for the gradient flow. We find that for this set of gauge field ensembles Zeuthen flow with Symanzik operators has the most consistent approach to the continuum limit and exhibit very small cutoff corrections. Tree-level improvement, traditionally used in step-scaling studies, significantly reduces the spread between different operators, but does not lead to an overall improvement when it comes to reducing cutoff effects for gradient flow scales $\sqrt{t_0}$ or $w_0$.Comment: 9 pages, 6 figures, contribution to the 39th International Symposium on Lattice Field Theory, August 8-13 2022, Bonn, German

Концепт «устойчивое развитие / sustainable development» в русскоязычном и англоязычном дискурсе сферы природопользования

Работа нацелена на выявление особенностей концепта "устойчивое развитие / sustainable development", объективированного в русскоязычном и англоязычном дискурсе сферы природопользования. Были выявлены и систематизированы единицы объективации рассматриваемого концепта, определены основные когнитивные признаки концепта "устойчивое развитие / sustainable development", формирующие его содержание и полевую структуру в русскоязычном и англоязычном дискурсе сферы природопользования. Набор выявленных когнитивных признаков концепта "устойчивое развитие / sustainable development" представлен в виде макроструктуры и полевой структуры, сделаны выводы об особенностях объективации исследуемого концепта в русскоязычном и англоязычном дискурсе сферы природопользования.The research aim is to identify peculiarities of the concept "устойчивое развитие / sustainable development", presented in the Russian-language and English-language discourse of natural management, which were identified and systematized units objectifying this concept, described the main cognitive features concept "устойчивое развитие / sustainable development", which build its content in the Russian-language and English-language discourse of natural management. The identified cognitive features of the concept "устойчивое развитие / sustainable development" are presented in form of its macrostructure and field organization. We also have made conclusions about peculiarities of objectification of this concept in the Russian- language and English-language discourse of natural management

Zafar, Capital of Himyar, Ibb Province, Yemen: First Preliminary Report: Summer 1998 and Autumn 2000, Second Preliminary Report: 2002, Third Preliminary Report: 2003, Fourth Preliminary Report: 2004

In 1998, the Heidelberg University Expedition to Zafar, in the Yemenite Highlands, initiated a programme of excavation, mapping and training. Zafar was the capital of the tribal confederation known to the outside world as Himyar, which for some 250 years dominated the entire Arabian Peninsula politically and militarily. The mapping showed the ancient walled city to be worthy of its name with a core area comprising some 1000 x 1200 m. The 2000 season concentrated on the excavation of a late Himyarite cemetery on a mountain slope called al-Asima/Salm. During the 2002 season, a foundation at the southern foot of the famous Husn Raydan was excavated, the site museum was newly installed and all of the inscriptions were photographed. In 2003, we photographed the entire collection of sculptures and began excavation on the south-western flank of the Husn Raydan in what appears to be magazines. Finally, in 2004 excavation was taken up in an area 10 m to the south, where a corner of a large limestone building came to light. Parts of the site were investigated by means of magnetometer survey. Until this time, experts described Zafar as utterly ruined and decadent in terms of its material culture. The foregoing contains the first preliminary report of the fieldwork in Zafar, a project which attempts to illuminate the latter part of the late pre-Islamic period

Using CAD in final quilifying works of bachelors

There are considered the possibility of using CAD in final qualifying works of bachelors. There are shown practical application of skills for future job of Graduates Automating the processes of heat and power. One of the graduate’s activities is design of functional, principle and wiring scheme. These types of schemes are included in the compulsory set of demonstration material. Quality of schemes speaks about professionalism of bachelors and gives potential employers opportunity to assess how professional designer. Students in the performance of graphics use different CAD systems such as AutoCAD, Microsoft Visio, Compas. Work designer and installer is impossible without knowledge some different CAD system. CAD systems are taught in several disciplines of the educational process

Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models

A newly developed UVC LED source with an emission wavelength of 233 nm was proved on bactericidal efficacy and skin tolerability. The bactericidal efficacy was qualitatively analysed using blood agar test. Subsequently, quantitative analyses were performed on germ carrier tests using the MRSA strain DSM11822, the MSSA strain DSM799, S. epidermidis DSM1798 with various soil loads. Additionally, the compatibility of the germicidal radiation doses on excised human skin and reconstructed human epidermis was proved. Cell viability, DNA damage and production of radicals were assessed in comparison to typical UVC radiation from discharge lamps (222 nm, 254 nm) and UVB (280-380 nm) radiation for clinical assessment. At a dose of 40 mJ/cm(2), the 233 nm light source reduced the viable microorganisms by a log(10) reduction (LR) of 5 log(10) levels if no soil load was present. Mucin and protein containing soil loads diminished the effect to an LR of 1.5-3.3. A salt solution representing artificial sweat (pH 8.4) had only minor effects on the reduction. The viability of the skin models was not reduced and the DNA damage was far below the damage evoked by 0.1 UVB minimal erythema dose, which can be regarded as safe. Furthermore, the induced damage vanished after 24 h. Irradiation on four consecutive days also did not evoke DNA damage. The radical formation was far lower than 20 min outdoor visible light would cause, which is classified as low radical load and can be compensated by the antioxidant defence system

Erythematous capillary-lymphatic malformations mimicking blood vascular anomalies

Superficial erythematous cutaneous vascular malformations are assumed to be blood vascular in origin, but cutaneous lymphatic malformations can contain blood and appear red. Management may be different and so an accurate diagnosis is important. Cutaneous malformations were investigated through 2D histology and 3D whole-mount histology. Two lesions were clinically considered as port-wine birthmarks and another 3 lesions as erythematous telangiectasias. The aims were (i) to demonstrate that cutaneous erythematous malformations including telangiectasia can represent a lymphatic phenotype, (ii) to determine if lesions represent expanded but otherwise normal or malformed lymphatics, and (iii) to determine if the presence of erythrocytes explained the red color. Microscopy revealed all lesions as lymphatic structures. Port-wine birthmarks proved to be cystic lesions, with nonuniform lymphatic marker expression and a disconnected lymphatic network suggesting a lymphatic malformation. Erythematous telangiectasias represented expanded but nonmalformed lymphatics. Blood within lymphatics appeared to explain the color. Blood-lymphatic shunts could be detected in the erythematous telangiectasia. In conclusion, erythematous cutaneous capillary lesions may be lymphatic in origin but clinically indistinguishable from blood vascular malformations. Biopsy is advised for correct phenotyping and management. Erythrocytes are the likely explanation for color accessing lymphatics through lympho-venous shunts

Outcome after pediatric liver transplantation for staged abdominal wall closure with use of biological mesh—Study with long‐term follow‐up

Abdominal wall closure after pediatric liver transplantation (pLT) in infants may be hampered by graft-to-recipient size discrepancy. Herein, we describe the use of a porcine dermal collagen acellular graft (PDCG) as a biological mesh (BM) for abdominal wall closure in pLT recipients. Patients <2 years of age, who underwent pLT from 2011 to 2014, were analyzed, divided into definite abdominal wall closure with and without implantation of a BM. Primary end-point was the occurrence of postoperative abdominal wall infection. Secondary end-points included 1- and 5-year patient and graft survival and the development of abdominal wall hernia. In five out of 21 pLT recipients (23.8%), direct abdominal wall closure was achieved, whereas 16 recipients (76.2%) received a BM. BM removal was necessary in one patient (6.3%) due to abdominal wall infection, whereas no abdominal wall infection occurred in the no-BM group. No significant differences between the two groups were observed for 1- and 5-year patient and graft survival. Two late abdominal wall hernias were observed in the BM group vs none in the no-BM group. Definite abdominal wall closure with a BM after pLT is feasible and safe when direct closure cannot be achieved with comparable postoperative patient and graft survival rates

Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center

Background and purpose: To analyze clinical trial activities and patient recruitment numbers into prospective clinical studies for solid malignancies during the COVID-19 pandemic in a tertiary cancer center. Materials and methods: Patient recruitment numbers in prospective clinical studies of solid malignancies were retrospectively analyzed for the years 2019 – 2021 at the Comprehensive Cancer Center Zurich (CCCZ). Changes in recruitment numbers were tested for association with organ-specific subunits, as well as organizational and treatment-related trial characteristics. To assess differences between categorical variables, Chi-squared test was used. For uni- and multivariate analysis, Cox proportional hazards were calculated. Results: In 2019, there were a total of 107 studies (registry trials, clinical phase I-III trials, and translational studies) recruiting 304 patients at the CCCZ. During the COVID-19 pandemic in 2020 and 2021, there were 120 and 125 active trials with a total recruitment of 355 and 666 patients, respectively. No significant differences between the subunits and study characteristics in changes of patient recruitment in clinical phase I-III trials were identified when the year prior to the COVID-19 pandemic (2019) was compared to the first year of the pandemic (2020) and to 2020-2021. Conclusions: Despite healthcare systems around the world have experienced significant disruption due to the COVID-19 pandemic, data from our tertiary cancer center showed that clinical trial activities were maintained at a high level during the pandemic

Appbasierte Förderansätze für Kinder mit Lernstörungen

Hintergrund: Einstellungen zu digitalen Fördermaßnahmen wurden bislang hauptsächlich aus der Sicht von Lehrkräften untersucht, obwohl das Lernen mit digitalen Hilfsmitteln im häuslichen Umfeld an Bedeutung gewinnt. Deshalb wird der Frage nachgegangen, wie Angehörige/Eltern von Kindern mit Lernstörungen (= KmL: Rechenstörung, Lesestörung bzw. kombinierte Lernstörung) die Förderung mit Trainings-Apps via Tablet in der häuslichen Umgebung erleben und was für sie in diesem Kontext wichtig ist. Methoden: Mithilfe leitfadengestützter Expert_inneninterviews wurden 21 Angehörige von KmL und zwei Projektbegleiterinnen, die im regelmäßigen Austausch mit den Angehörigen standen, interviewt; zusätzlich wurden mit einem schriftlichen Fragebogen qualitative Datensätze zum Lernerleben mit den Apps sowie zur allgemeinen Wahrnehmung der Apps aus der Perspektive von 1) KmL (n = 83), welche die Trainings-App genutzt haben, und 2) weiteren Angehörigen (n = 81) erhoben. Ergebnis: Durch qualitative Analysen wurden Gelingensbedingungen (z.B. das Engagement der Angehörigen), aber auch Herausforderungen für die Verwendung von Trainings-Apps (z.B. technische Schwierigkeiten, Missverständnisse, Qualität der Stimmausgabe, als unpassend empfundener Schwierigkeitsgrad) herausgearbeitet. Diskussion: Aktuell wird das Training wahlweise als zu schwer, zu leicht oder zu ausufernd wahrgenommen. Um hier eine individuelle Passung zu erreichen, ist weitere Forschung sowie Entwicklung notwendig.Background: While learning with digital tools gains increasing importance, attitudes towards digital intervention tools have so far mainly been investigated from the perspective of teachers. Therefore, the question is investigated how relatives/parents of children with specific educational learning disorders (= CwLD: dyscalculia, reading disorder or combined learning disorder) experience the support with training apps via tablet in their home environment and what is important for them in this context. Methods: Using guideline-based expert interviews, 21 relatives of CwLD and two female employees, who worked as technical support and were in regular contact with the relatives, were interviewed; in addition, a questionnaire was used to collect qualitative data sets on the learning experience with the apps and on the general perceptions of the apps from the perspective of 1) the CwLD (n = 83) who used the training app and 2) other relatives (n = 81). Results: With qualitative analyses conditions for success (e.g., engagement of relatives) but also limitations to the use of training apps (e.g., technical difficulties, misunderstandings, voice output, perceived inappropriateness of training difficulty) were identified. Discussion: Currently, training is perceived as either too difficult, too easy, or too extensive. To achieve an individual fit, further research and development is necessary