In Situ Hybridization Pada Kanker Payudara

Kesulitan yang dijumpai pada penanganan kanker payudara adalah terjadinya kekambuhan atau relaps. Deteksi status HER2 pada pasien merupakan salah satu upaya untuk mendeteksi terjadinya relaps dan juga untuk menentukan jenis terapi yang ada diberikan. Ekspresi protein HER2 dapat dideteksi dengan immunohistochemistry (IHC), sedangkan mutasi gen HER2 dapat dideteksi dengan teknik in situ hybridization baik berupa fluorescence in situ hybridization (FISH) ataupun chromogenic in situ hybridization (CISH). Metode yang digunakan antara penggunaan CISH maupun FISH serupa. Hal yang membedakan antara keduanya adalah pada CISH pewarnaannya bersifat permanen dan terdapat gambaran back-ground. Kelebihan lain yang diperoleh pada aplikasi CISH adalah reaksi peroksidase yang terjadi dapat divisualisasikan pada mikroskop cahaya

PEMBERDAYAAN TEMPAT PENITIPAN ANAK (TPA) DALAM PENGELOLAAN PENYAKIT MENULAR SERTA SKRINING TUMBUH KEMBANG ANAK DI TPA PURI RARE KOTA DENPASAR

Day care centers are currently experiencing significant developments with the many needs of the community and demands of parents to work. So that many parents leave their children in child care centers (TPA). Puri Rare Day Care is one of the TPAs in the city of Denpasar. Several toddlers and children were sent there. Toddlers and children are vulnerable to infection in TPA, so the aim of this Service is to provide knowledge about infectious diseases and their prevention and training to use self-protection tools and screening for child development. Mita's participation reached 100% and there was an increase in partners' knowledge about child infectious diseases and how to prevent them as well as child growth and development from 53.33 to 86.67% and monitoring and evaluation every 2 weeks to see the ability of partners in screening growth and development and prevention of infection. After carrying out PKM activities, it can be concluded that there is an increase in partners' knowledge about infectious diseases and their prevention and how to screen children's growth and development

PEMBERDAYAAN KELOMPOK IBU YANG MEMILIKI BALITA BERISIKO STUNTING DI BANJAR TRIWANGSA-PAYANGAN GIANYAR BALI

Stunting is still a major nutritional problem in Indonesia and Bali. One district that has a fairly high stunting rate is Bresela Village, Payangan District. Triwangsa is one of the district located in Bresela village, based on a quick survey conducted on pregnant women and mothers who have babies under two years old in Triwangsa district, Bresela Village, Payangan, low knowledge and bad attitudes and behavior towards stunting prevention especially in terms of time, type and form of complementary feeding as a nutritional intake for the first 1000 days of life. The service implementation method is in the form of interactive dialogue and a demonstration of making balanced solid food. This activity succeeded in increasing partners' knowledge by 75% regarding stunting and balanced complementary foods of breast milk. After the assistance is carried out, it can be seen that the behavior changes of partners in providing balanced complementary foods to toddlers

Utilization review inpatient and outpatient of traveller related to thypoid in Bali (study in two regencies: a case report)

Bali is a tourism destination for foreign tourist who plan to do business or just on vacation. Bali is a tropical area that susceptible to various diseases. Foreign tourists who were enjoying their travel will experience health problem in the case of improper vaccination. The aim of this study was to evaluate the frequency of typhoid cases among travellers visited clinics in Bali. A retrospective study was conducted based on the medical record of the patientssuffered with thyphoid infections in Bali. The highest finding of typhoid patient visiting clinics is Badung Regency

Chikungunya fever outbreak identified in North Bali, Indonesia

Background: Chikungunya virus (CHIKV) infections have been reported sporadically within the last 5 years in several areas of Indonesia including Bali. Most of the reports, however, have lacked laboratory confirmation. Method: A recent fever outbreak in a village in the North Bali area was investigated using extensive viral diagnostic testing including both molecular and serological approaches. Results and conclusions: Ten out of 15 acute febrile illness samples were confirmed to have CHIKV infection by real-time PCR or CHIKV-specific IgM enzyme-linked immunosorbent assay (ELISA). The outbreak strain belonged to the Asian genotype with highest homology to other CHIKV strains currently circulating in Indonesia. The results are of public health concern particularly because Bali is a popular tourist destination in Indonesia and thereby the potential to spread the virus to non-endemic areas is high

Hubungan Efikasi Diri dengan Tingkat Kecemasan dalam Menghadapi Ujian Blok pada Mahasiswa Tahun Pertama Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa

Self-efficacy is an individual's belief in his ability to manage the situation experienced. Situations that often occur when facing exams are anxiety that occurs because of psychological and intrapsychic responses. The purpose of the study was to find out how the relationship between self-efficacy and level of anxiety in facing exams in early-level students of the Faculty of Medicine and Health Sciences, Warmadewa University. This study uses a correlational analytic with cross- sectional approach. The method of collecting data on respondents' self-efficacy was using the General Self Efficacy (GSE) questionnaire technique and the anxiety in facing the block exam was using the Hamilton Anxiety Rating Scale (HARS) questionnaire. Samples were analyzed using univariate and bivariate analysis techniques. It was found that respondents who did not experience anxiety in facing the block exam were 61.3%, those who experienced mild anxiety in facing the block exam were 18.7%, 9%, severe 9.7%, and very severe 1.3%. Respondents who have a very high level of self-efficacy 14.2%, high 85.2%, low 0.6%, and very low 0%. The p- value of this study is 0.000. Because the value (p) 0.00 <0.05, which indicates that there is a significant relationship between self-efficacy and anxiety levels. The value obtained is -0.612 which indicates the strength of its strength. This means that there is a relationship between self- efficacy and facing examinations for early-level students of the Faculty of Medicine and Health Sciences, Warmadewa UniversityEfikasi diri ialah keyakinan seseorang terhadap daya kelola situasi yang dialami. Situasi yang sering terjadi saat mahasiswa menghadapi ujian adalah kecemasan yang terjadi karena adanya respon psikologis dan intrapsikis. Tujuan penelitian untuk mengetahui bagaimana hubungan dari efikasi diri dan taraf kecemasan dalam menghadapi ujian blok pada mahasiswa tahun pertama Fakultas Kedokteran dan Ilmu Kesehatan di Universitas Warmadewa. Adapun penelitian mempergunakan metode analitik korelasional, pendekatan cross-sectional. Cara memperoleh data responden efikasi diri menggunakan teknik kuesioner General Self Efficacy (GSE) dan kecemasan dalam menghadapi ujian blok mempergunakan angket Hamilton Anxiety Rating Scale (HARS). Dalam menganalisis data mempergunakan SPSS pengujian Gamma untuk mengetahui keeratan hubungan antara variabel tersebut. Diperoleh temuan yakni responden yang tidak cemas ketika menghadapi ujian blok 61,3%, yang mengalami kecemasan ringan dalam menghadapi ujian blok 18,7%, sedang 9%, berat 9,7%, dan sangat berat 1,3%. Responden yang memiliki tingkat efikasi diri sangat tinggi 14,2%, tinggi 85,2%, rendah 0,6%, dan sangat rendah 0%. Nilai p dari penelitian ini yaitu 0,000. Nilai (p) yakni 0,00 < 0,05, artinya ada korelasi signifikan diantara efikasi diri dan tingkat kecemasan. Adapun nilai γ yaitu -0,612, ini berarti daya korelasinya kuat. Jadi terdapat korelasi diantara efikasi diri dan kecemasan menghadapi ujian blok pada mahasiswa yang menjalani tahun pertama di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadew

Gambaran Pasien Katarak dengan Riwayat Diabetes Melitus di Rumah Sakit Mata Bali Mandara

The condition in which the usually clear and clear lens of the eye turns cloudy is called a cataract. In Indonesia, cataracts are the main cause of blindness with a percentage of 77.7%. Data obtained from the Bali Mandara Eye Hospital in 2018 stated that the percentage of cataracts in the province of Bali was 2.7%. Various factors can cause cataracts, diabetes mellitus is one of them. Increased blood sugar levels in patients with diabetes mellitus will provide clearly visible changes in body tissues that are not dependent on insulin for glucose transport. This can occur in the lens of the eye which can cause cataracts. This study aims to determine the description of cataract patients with a history of diabetes mellitus at the Bali Mandara Eye Hospital. This research method is descriptive retrospective with a cross-sectional study design. The data collection method used secondary data from medical records. The research sample was all cataract patients who checked themselves at the Bali Mandara Eye Hospital and met the criteria set by the purposive sampling technique. The data obtained were analyzed univariately. In this study, it was found that patients with cataracts with a history of diabetes mellitus were dominated by female patients and patients with an age range of 50-60 years. Based on the classification suffered, patients with immature cataracts are the most common. Based on the blood sugar levels obtained during the examination, most of the patients had high blood sugar levels.Keadaan lensa mata yang biasanya bening dan jernih berubah menjadi keruh disebut dengan katarak. Di Indonesia, katarak menjadi penyebab utama terjadinya kebutaan dengan persentase sebesar 77,7% serta data yang didapat dari Rumah Sakit Mata Bali Mandara tahun 2018 menyatakan persentase katarak di provinsi Bali sebesar 2,7%. Katarak dapat disebabkan dari berbagai faktor, diabetes melitus merupakan salah satunya. Kadar gula darah yang terjadi peningkatan pada pasien diabetes melitus dapat memberikan perubahan yang terlihat jelas di jaringan tubuh yang tidak terikat dengan insulin dalam transport glukosa. Hal ini dapat terjadi pada lensa mata dimana dapat menimbulkan katarak. Penelitian ini bertujuan untuk mengetahui gambaran pasien katarak dengan riwayat diabetes melitus di RS Mata Bali Mandara. Metode penelitian ini ialah deskriptif retrospektif dengan rancangan studi cross sectional. Metode yang digunakan dalam pengumpulan data adalah dengan data skunder dari rekam medis. Sampel penelitian adalah seluruh pasien katarak yang memeriksakan diri di RS Mata Bali Mandara yang memenuhi kriteria yang telah ditetapkan dengan teknik purposive sampling. Data yang didapat dianalisis secara univariat. Pada penelitian ini mendapatkan hasil bahwa pasien yang mengalami katarak dengan riwayat diabetes melitus didominasi oleh pasien perempuan dan pasien dengan rentang usia 50-60 tahun. Berdasarkan klasifikasinya yang diderita, pasien dengan katarak imatur adalah yang paling banyak ditemukan. Berdasarkan kadar gula darah yang didapatkan saat pemeriksaan, sebagian besar pasien memiliki kadar gula darah yang tinggi

Pembinaan Ibu Balita dalam Pencegahan Stunting di Desa Kelusa, Payangan, Gianyar

Village of Kelusa is located in the district of Payangan, region of Gianyar, province of Bali. Geographically, the majority of Kelusa’s area is utilized for agriculture with irrigation as the water system. This agriculture is the source of local-based products for daily consumption of Kelusa’s population. Food security is one essential factor to prevent the nutritional disorder, such as in stunting. However, regarding the report from Public Health Office of Gianyar in the 2022, there was still 278 stunted toddlers (13,7%) and  173 stunted in below two years of age children (21,5%) in the area of Payangan. Through analysis and observation, there were some problems found in the village of Kelusa, including the lack of mother’s knowledge on stunting and its prevention, processing healthy weaning food, also preparing and serving weaning food to increase appetite when the child is sick. Regarding these problems, an empowerment was conducted to the community partners, which were the toddlers’ mothers, about stunting and its prevention, also the management of weaning food which is suited to the child’s age. The empowerment was integrated with the faculty students’ learning activites called Community Oriented Medical Education, in which every toddler’s family was accompanied by one faculty student continuously during the first 1000 days of life. After the health education was given, there was a 44% increase in post-test score compared to the pretest. Regarding this result, there was a significant rise of knowledge in toddlers’ mothers after the implementation of health education. Health promotion can give an impact in the mother’s knowledge about stunting, preventing stunting, and managing weaning food. These increase of knowledge and perspective would construct positive attitude and behavior in preventing stunting and managing healthy weaning food. The continuity of health education and workshop on the management of healthy weaning food to optimize the first 1000 days of life should be integrated to the community-based health effort (UKBM), such as in Posyandu and Poskesdes. Moreover, these programs can be implemented to the targeted population, such as pregnant mother and toddler’s mother, as well as the posyandu and village cadres to increase their competencies in preventing stunting on toddlers

Hubungan antara Indeks Massa Tubuh dengan Hernia Inguinalis di Poli Bedah RSUD Sanjiwani Gianyar

         Hernia inguinalis adalah persoalan yang umumnya ditemui pada saat pembedahan dan bisa diderita oleh semua umur. Hernia inguinalis lebih sering terjadi pada  laki-laki dibandingkan perempuan, unsur penyebab yang bisa dijadikan sebagai etiologi hernia inguinalis yakni kenaikan intra-abdomen dan kelemahan otot dinding perut. Overweight dan obesitas merupakan contoh aspek risiko yang bisa memberikan pengaruh maupun menaikkan probabilitas hernia inguinalis terjai. Namun, Beberapa studi memiliki pendapat yang berbeda, bahwa insiden hernia inguinalis lebih sedikit di penderita obesitas serta overweight daripada individu dengan berat badan normal. Unsur indeks massa tubuh yang dikorelasikan dengan hernia inguinalis merupakan landasan untuk riset ini dilaksanakan. Riset ini mempunyai tujuan guna mengidentifikasi Hubungan antara Indeks Massa Tubuh dengan Hernia Ingunlasi di Poli Bedah RSUD Sanjiwani. Penelitian ini menggunakan metode riset analisis pengamatan dengan rancangan studi cross sectional. Metode pengumpulan sampel melalui teknik Purposive sampling. Sampel yang didapatkan lalu dianalisa serta dilakukan pengujian statistika menggunakan Chi-Square. Sampel yang didapatkan yakni 135 pasien, didalamnya terdapat 64 (47,4%) terdiagnosis hernia inguinalis dan 71 (52,6%) tidak terdiagnosis hernia ingunalis. Untuk melihat signifikansi pengaruh IMT terhadap kejadian hernia inguinalis, dilaksanakan pengujian Chi Square dengan nilai signifikansi sebesar 0,05. Nilai p pada uji chi square yang dilakukan sebesar 0,220. Nilai itu melebihi 0,05 sehingga bisa diambil kesimpulan bahwa IMT tidak berpengaruh secara berarti atas kejadian hernia inguinalis.ABSTRACT                   Inguinal hernia is a problem that is commonly found in surgical cases and can be suffered by all ages. Inguinal hernias are commonly found in men than women, risk factors that can be the etiology of inguinal hernias are increased intra-abdominal and abdominal wall muscle weakness. Overweight and obesity are risk factors that can influence or increase the occurrence of inguinal hernia. However, several studies have a different opinion, that the case of inguinal hernia is fewer in obesity and overweight compared to normal weight. The body mass index factor relation with inguinal hernia is the main focus on this study. This study aims to determine the relationship between Body Mass Index and Inguinal Hernia at the Surgical Clinic of the Sanjiwani Hospital. This study used an observational analytic research method with a cross sectional study design. The sampling technique used was purposive sampling method. The samples obtained were then analyzed and statistically tested with Chi-Square. The samples obtained were 135 patients, consisting of 64 (47.4%) diagnosed inguinal hernia and 71 (52.6%) undiagnosed inguinal hernia. To see the significance of the effect of BMI on the incidence of inguinal hernia, a Chi Square test was carried out with a significance value of 0.05. The p value of the chi square test carried out is 0.220. This value is more than 0.05 so it can be concluded that BMI has no impactful effect on the incidence of inguinal hernia