Introducing the Anatomy of Resistance Campaigns (ARC) dataset

We introduce the Anatomy of Resistance Campaigns (ARC) dataset, which records information on 1,426 organizations that participated in events of maximalist violent and nonviolent contention in Africa from 1990 to 2015. The ARC dataset contains 17 variables covering organization-level features such as type, age, leadership, goals, and interorganizational alliances. These data facilitate new measurements of key concepts in the study of contentious politics, such as the social and ideological diversity of resistance episodes, in addition to measures of network centralization and fragmentation. The ARC dataset helps resolve existing debates in the field and opens new avenues of inquiry. © The Author(s) 2022.Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Southwest Norway at the Pleistocene/ Holocene Transition: Landscape Development, Colonization, Site Types, Settlement Patterns

This is an electronic version of an article published in the Norwegian Archaeological Review© 2003 Copyright Taylor & Francis; Norwegian Archaeological Review is available online at http://www.tandfonline.com/doi/abs/10.1080/00293650307293.This article contributes a western Norwegian perspective to the ongoing debate on the timing and nature of the earliest colonization of northern Europe. Despite there being a theoretical possibility of Late Glacial settlement, currently available data indicate a populating of the area around the termination of the Pleistocene ca. 10,000 (uncalibrated) yr BP. The earliest radiocarbon date in southwest Norway so far, 9750 BP, is only a terminus ante quem. Environmental, economic, technological and social factors involved as a result of the colonization process are discussed briefly, and trends in the archaeological record are emphasized and commented on. The economy reflected by the first complete annual subsistence patterns is interpreted as having been logistically mobile, highly adaptive and generally of opportunistic character. Particular attention is paid to Early Preboreal coastal and inland settlement of the ‘Boknafjord’ and ‘Myrvatn/Fløyrlivatn’ groups, the latter characterized by well-preserved site structures such as tent rings and hearths providing high-resolution radiocarbon dates and palaeobotanical evidence

A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish

Mitochondria are a dynamic eukaryotic innovation that play diverse roles in biology and disease. The mitochondrial genome is remarkably conserved in all vertebrates, encoding the same 37-gene set and overall genomic structure, ranging from 16,596 base pairs (bp) in the teleost zebrafish (Danio rerio) to 16,569 bp in humans. Mitochondrial disorders are amongst the most prevalent inherited diseases, affecting roughly 1 in every 5000 individuals. Currently, few effective treatments exist for those with mitochondrial ailments, representing a major unmet patient need. Mitochondrial dysfunction is also a common component of a wide variety of other human illnesses, ranging from neurodegenerative disorders such as Huntington’s disease and Parkinson’s disease to autoimmune illnesses such as multiple sclerosis and rheumatoid arthritis. The electron transport chain (ETC) component of mitochondria is critical for mitochondrial biology and defects can lead to many mitochondrial disease symptoms. Here, we present a publicly available collection of genetic mutants created in highly conserved, nuclear-encoded mitochondrial genes in Danio rerio. The zebrafish system represents a potentially powerful new opportunity for the study of mitochondrial biology and disease due to the large number of orthologous genes shared with humans and the many advanced features of this model system, from genetics to imaging. This collection includes 15 mutant lines in 13 different genes created through locus-specific gene editing to induce frameshift or splice acceptor mutations, leading to predicted protein truncation during translation. Additionally, included are 11 lines created by the random insertion of the gene-breaking transposon (GBT) protein trap cassette. All these targeted mutant alleles truncate conserved domains of genes critical to the proper function of the ETC or genes that have been implicated in human mitochondrial disease. This collection is designed to accelerate the use of zebrafish to study many different aspects of mitochondrial function to widen our understanding of their role in biology and human disease