27 research outputs found

    "You're still worth it": The moral and relational context of politically motivated unfriending decisions in online networks.

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    Political disagreements in social media can result in removing (i.e., "unfriending") a person from one's online network. Given that such actions could lead to the (ideological) homogenization of networks, it is pivotal to understand the psychological processes intertwined in unfriending decisions. This requires not only addressing different types of disagreements but also analyzing them in the relational context they occur. This article proposes that political disagreements leading to drastic measures such as unfriending are attributable to more deeply rooted moral dissents. Based on moral foundations theory and relationship regulation research, this work presents empirical evidence from two experiments. In both studies, subjects rated political statements (that violated different moral foundations) with regard to perceived reprehensibility and the likelihood of unfriending the source. Study 1 (N = 721) revealed that moral judgments of a political statement are moderately related to the unfriending decision. Study 2 (N = 822) replicated this finding but indicated that unfriending is less likely when the source of the morally reprehensible statement is relationally close to the unfriender and provides emotional support. This research extends unfriending literature by pointing to morality as a new dimension of analysis and offers initial evidence uncovering the psychological trade-off behind the decision of terminating digital ties. Drawing on this, our findings inform research on the homogenization of online networks by indicating that selective avoidance (in the form of politically motivated unfriending) is conditional upon the relational context and the interpersonal benefits individuals receive therein

    PPE Portraits - a Way to Humanize Personal Protective Equipment

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    The use of personal protective equipment (PPE) has skyrocketed, as providers don masks, glasses, and gowns to protect their eyes, noses, and mouths from COVID-19. Yet these same facial features express human individuality, and are crucial to nonverbal communication. Isolated ICU patients may develop post intensive-care syndrome, which mimics PTSD with sometimes debilitating consequences. While far from a complete solution, PPE Portraits (disposable portrait picture stickers - 4 x 5 ) have the potential to humanize care. Preparing for a larger effectiveness evaluation on patient and provider experience, we collected initial qualitative implementation insights during Spring 2020\u27s chaotic surge preparation. Front-line providers reported more comfort with patient interactions while wearing PPE Portraits: It makes it feel less like a disaster zone [for the patient]. A brief pilot showed signs of significant adoption: a participating physician requested PPE Portraits at their clinic, shift nurses had taken PPE Portraits with them to inpatient services, and masked medical assistant team-members requested PPE Portraits to wear over scrubs. We believe PPE Portraits may support patient care and health, and even potentially healthcare team function and provider wellness. While we await data on these effects, we hope hospitals can use our findings to speed their own implementation testing

    Loss of IL-1β impairs neutrophil recruitment to the gut during <i>Salmonella</i> infection.

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    (A) Pathway analysis of transcripts that are down-regulated in colonic tissue of Salmonella-infected IL-1β -/- according to GO biological function. Bars represent -log (P value) and dots represent number of genes in pathway. (B) Heatmap depicting differentially expressed innate immune genes with a P C, D) Numbers of NE-positive (C) and myeloperoxidase-positive (D) cells in colonic section of Salmonella-infected mice 4 d.p.i. Each dot represents a mouse. (E) Representative immunohistochemistry images of colonic section from Salmonella-infected mice stained with anti-neutrophil elastase antibody. Scale bar, 50 μm. (F) % of neutrophils out of total circulating WBC and (G) concentration of neutrophils in serum of WT and IL-1β -/- mice infected as indicated 4 d.p.i. *P P P P C and D) Student’s t test. (F and G) One-way ANOVA. d.p.i., days post-infection; S. Tm, Salmonella typhimurium. These data are representative of 2 independent experiments. Numerical values are in S1 Data. The underlying data for this figure can be found at GSE252071. NE, neutrophil elastase; WT, wild-type.</p

    Preservation of fatty acid beta-oxidation in <i>IL-1β</i> <sup><i>-/-</i></sup> mice inhibits <i>Salmonella</i> growth in vivo.

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    (A) Pathway analysis of transcripts that are up-regulated in colonic tissue of Salmonella-infected IL-1β -/- according to GO biological function. Bars represent -log (P value) and dots represent number of genes in pathway. (B) Heatmap depicting differentially expressed genes involved in fatty acid oxidation with a P C) Heatmap depicting differentially expressed genes in the glycolysis pathway with a P D) Immunofluorescence microscopy of colonic section from mice. Red staining shows pimonidazole that indicates hypoxia levels. Nuclei were stained with DAPI. Scale bar, 50 μm. (E) Quantification of red signal in (D). Each dot represents a mouse. (F) Salmonella C.F.U. in cecal contents of infected mice 4 d.p.i. treated as indicated. Each dot represents a mouse. **P P E) one-way ANOVA; (F) Mann–Whitney test. d.p.i., days post-infection; S. Tm, Salmonella typhimurium. These data are representative of 2 independent experiments. Numerical values are in S1 Data. The underlying data for this figure can be found at GSE252071.</p

    Vancomycin treatment depletes SCFA-producing <i>Clostridia</i> in mice.

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    16S rRNA sequencing was performed to characterize gut microbiota composition of mice treated with vancomycin for 3 days. Relative abundance (left) and absolute OTU reads (right) of SCFA-producing members of the Clostridia class at the family level. Each symbol represents a mouse. OTU, operational taxonomic unit. These data are representative of 1 experiment. **P t test. Numerical values are in S1 Data. (TIFF)</p

    Expression of <i>IL-1β</i> correlates with expression of the C3 receptor gene in sepsis patients.

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    (A–E) Analysis of whole-blood transcriptional microarray data from healthy humans treated intravenously with 2 ng/kg Escherichia coli lipopolysaccharide (LPS) (GSE134356). (F–J) Analysis of whole-blood RNA sequencing data from hospitalized sepsis patients and healthy controls (GSE154918). (K–M) Analysis of whole-blood transcriptional microarray data from patients admitted to the ICU with sepsis, without sepsis, or healthy controls (GSE134347). Each dot represents a patient. **P P P A–C and F–H) Student’s t test. (D, E, and I–M) Simple linear regression. TPM, transcripts per million. Numerical values are in S1 Data. ICU, intensive care unit; LPS, lipopolysaccharide.</p
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