Evidence of a past disc-disc encounter: HV and DO Tau

© 2018 The Author(s). Published by Oxford University Press on behalf of The Royal Astronomical Society. Theory and observations suggest that star formation occurs hierarchically due to the fragmentation of giant molecular clouds. In this case we would expect substructure and enhanced stellar multiplicity in the primordial cluster. This substructure is expected to decay quickly in most environments, however historic stellar encounters might leave imprints in a protoplanetary disc (PPD) population. In a low-density environment such as Taurus, tidal tails from violent star-disc or disc-disc encounters might be preserved over timescales sufficient to be observed. In this work, we investigate the possibility that just such an event occurred between HV Tau C (itself a component of a triple system) and DO Tau ~0.1 Myr ago, as evidenced by an apparent 'bridge' structure evident in the 160 μ m emission. By modelling the encounter using smoothed particle hydrodynamics (SPH) we reproduce the main features of the observed extended structure ('V'-shaped emission pointing west of HV Tau and a tail-like structure extending east of DO Tau). We suggest that HV Tau and DO Tau formed together in a quadruple system on a scale of ~5000 au (0.025 pc)

The FRIED grid of mass-loss rates for externally irradiated protoplanetary discs

We present an open access grid of 3930 calculations of externally evaporating protoplanetary discs. This spans a range of disc sizes (1-400AU), disc masses, UV field strengths (10-10$^4$G$_0$) and stellar masses (0.05-1.9M$_\odot$). The grid is publicly available for download, and offers a means of cheaply including external photoevaporation in disc evolutionary calculations. It can also be queried using an online tool for quick estimates of instantaneous mass loss rates (e.g for convenient evaluation of real observed systems). The `FRIED' grid itself illustrates that for discs around stars $\leq0.3$M$_\odot$ external photoevaporation is effective down to small radii ($<50$AU) down to UV fields at least as weak as 10G$_0$. At the other end of the scale, in a $10^4$G$_0$ environment photoevaporation is effective down to 1AU even for stellar masses at least as high as 1.9M$_\odot$. We also illustrate in which regimes CO survives in the photoevaporative outflow for significant mass loss rates; marking a system a good candidate to detect external photoevaporation in weak-intermediate UV environments through sub-Keplerian rotation. Finally we make illustrative mass loss rate estimates for discs in Taurus based on the Guilloteau et al. (2011) star-disc parameters, finding that around half are expected to have both significant mass loss and retain CO in the photoevaporative outflow.Comment: 16 pages, 9 figures. Accepted for publication in MNRA

Protoplanetary disc truncation mechanisms in stellar clusters: Comparing external photoevaporation and tidal encounters

Most stars form and spend their early life in regions of enhanced stellar density. Therefore the evolution of protoplanetary discs (PPDs) hosted by such stars are subject to the influence of other members of the cluster. Physically, PPDs might be truncated either by photoevaporation due to ultraviolet flux from massive stars, or tidal truncation due to close stellar encounters. Here we aim to compare the two effects in real cluster environments. In this vein we first review the properties of well studied stellar clusters with a focus on stellar number density, which largely dictates the degree of tidal truncation, and far ultraviolet (FUV) flux, which is indicative of the rate of external photoevaporation. We then review the theoretical PPD truncation radius due to an arbitrary encounter, additionally taking into account the role of eccentric encounters that play a role in hot clusters with a 1D velocity dispersion $\sigma_v > 2$ km/s. Our treatment is then applied statistically to varying local environments to establish a canonical threshold for the local stellar density ($n_{c} > 10^4$ pc$^{-3}$) for which encounters can play a significant role in shaping the distribution of PPD radii over a timescale $\sim 3$ Myr. By combining theoretical mass loss rates due to FUV flux with viscous spreading in a PPD we establish a similar threshold for which a massive disc is completely destroyed by external photoevaporation. Comparing these thresholds in local clusters we find that if either mechanism has a significant impact on the PPD population then photoevaporation is always the dominating influence.ERC Advanced Grant grant agreement 34113

The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence: a national retrospective study using molecular epidemiology

Background: HIV is known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in lowincidence settings. Methods: National surveillance data from England, Wales and Northern Ireland on tuberculosis cases in adults from 2010 to 2014, strain typed using 24-locus mycobacterial-interspersed-repetitive-units–variable-number-tandem-repeats was used retrospectively to identify clusters of tuberculosis cases, subdivided into ‘first’ and ‘subsequent’ cases. Firstly, we used zero-inflated Poisson regression models to examine the association between HIV status and the number of subsequent clustered cases (a surrogate for tuberculosis infectiousness) in a strain type cluster. Secondly, we used logistic regression to examine the association between HIV status and the likelihood of being a subsequent case in a cluster (a surrogate for recent acquisition of tuberculosis infection) compared to the first case or a non-clustered case (a surrogate for reactivation of latent infection). Results: We included 18,864 strain-typed cases, 2238 were the first cases of clusters and 8471 were subsequent cases. Seven hundred and fifty-nine (4%) were HIV-positive. Outcome 1: HIV-positive pulmonary tuberculosis cases who were the first in a cluster had fewer subsequent cases associated with them (mean 0.6, multivariable incidence rate ratio [IRR] 0.75 [0.65–0.86]) than those HIV-negative (mean 1.1). Extra-pulmonary tuberculosis (EPTB) cases with HIV were less likely to be the first case in a cluster compared to HIVnegative EPTB cases. EPTB cases who were the first case had a higher mean number of subsequent cases (mean 2.5, IRR (3.62 [3.12–4.19]) than those HIV-negative (mean 0.6). Outcome 2: tuberculosis cases with HIV co-infection were less likely to be a subsequent case in a cluster (odds ratio 0.82 [0.69–0.98]), compared to being the first or a non-clustered case. Conclusions: Outcome 1: pulmonary tuberculosis-HIV patients were less infectious than those without HIV. EPTB patients with HIV who were the first case in a cluster had a higher number of subsequent cases and thus may be markers of other undetected cases, discoverable by contact investigations. Outcome 2: tuberculosis in HIV-positive individuals was more likely due to reactivation than recent infection, compared to those who were HIV-negative

External photoevaporation of protoplanetary discs in Cygnus OB2: Linking discs to star formation dynamical history

Many stars form in regions of enhanced stellar density, where stellar neighbours can have a strong influence on a protoplanetary disc (PPD) population. In particular, far-ultraviolet (FUV) flux from massive stars drives thermal winds from the outer edge of PPDs, accelerating disc destruction. Here, we present a novel technique for constraining the dynamical history of a star-forming environment using PPD properties in a strongly FUV-irradiated environment. Applying recent models for FUV-induced mass-loss rates to the PPD population of Cygnus OB2, we constrain the time since primordial gas expulsion. This is 0.5 Myr ago if the Shakura & Sunyaev α-viscosity parameter is α = 10 −2 (corresponding to a viscous timescale of τ visc ≈ 0.5 Myr for a disc of scale radius 40 au around a 1 M star). This value of α is effectively an upper limit, since it assumes efficient extinction of FUV photons throughout the embedded phase. This gas expulsion time-scale is consistent with a full dynamical model that fits kinematic and morphological data as well as disc fractions. We suggest Cygnus OB2 was originally composed of distinct massive clumps or filaments, each with a stellar mass ∼10 4 M. Finally we predict that in regions of efficient FUV-induced mass-loss, disc mass M disc as a function of stellar host mass m star follows a power law with M disc ∝ m βstar , where β exceeds ∼2.7 – steeper than correlations observed in regions of moderate FUV flux (1 < β < 1.9). This difference offers a promising diagnostic of the influence of external photoevaporation in a given region.This work has been supported by the DISCSIM project, grant agreement 341137 funded by the European Research Council under ERC-2013-ADG. AJW thanks the Science and Technology Facilities Council (STFC) for their studentship

The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence:A national retrospective study using molecular epidemiology

BACKGROUND: HIV is known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in low-incidence settings. METHODS: National surveillance data from England, Wales and Northern Ireland on tuberculosis cases in adults from 2010 to 2014, strain typed using 24-locus mycobacterial-interspersed-repetitive-units-variable-number-tandem-repeats was used retrospectively to identify clusters of tuberculosis cases, subdivided into 'first' and 'subsequent' cases. Firstly, we used zero-inflated Poisson regression models to examine the association between HIV status and the number of subsequent clustered cases (a surrogate for tuberculosis infectiousness) in a strain type cluster. Secondly, we used logistic regression to examine the association between HIV status and the likelihood of being a subsequent case in a cluster (a surrogate for recent acquisition of tuberculosis infection) compared to the first case or a non-clustered case (a surrogate for reactivation of latent infection). RESULTS: We included 18,864 strain-typed cases, 2238 were the first cases of clusters and 8471 were subsequent cases. Seven hundred and fifty-nine (4%) were HIV-positive. Outcome 1: HIV-positive pulmonary tuberculosis cases who were the first in a cluster had fewer subsequent cases associated with them (mean 0.6, multivariable incidence rate ratio [IRR] 0.75 [0.65-0.86]) than those HIV-negative (mean 1.1). Extra-pulmonary tuberculosis (EPTB) cases with HIV were less likely to be the first case in a cluster compared to HIV-negative EPTB cases. EPTB cases who were the first case had a higher mean number of subsequent cases (mean 2.5, IRR (3.62 [3.12-4.19]) than those HIV-negative (mean 0.6). Outcome 2: tuberculosis cases with HIV co-infection were less likely to be a subsequent case in a cluster (odds ratio 0.82 [0.69-0.98]), compared to being the first or a non-clustered case. CONCLUSIONS: Outcome 1: pulmonary tuberculosis-HIV patients were less infectious than those without HIV. EPTB patients with HIV who were the first case in a cluster had a higher number of subsequent cases and thus may be markers of other undetected cases, discoverable by contact investigations. Outcome 2: tuberculosis in HIV-positive individuals was more likely due to reactivation than recent infection, compared to those who were HIV-negative

Protoplanetary disc response to distant tidal encounters in stellar clusters

The majority of stars form in a clustered environment. This has an impact on the evolution of surrounding protoplanetary discs (PPDs) due to either photoevaporation or tidal truncation. Consequently, the development of planets depends on formation environment. Here we present the first thorough investigation of tidally induced angular momentum loss in PPDs in the distant regime, partly motivated by claims in the literature for the importance of distant encounters in disc evolution. We employ both theoretical predictions and dynamical/hydrodynamical simulations in 2D and 3D. Our theoretical analysis is based on that of Ostriker (1994) and leads us to conclude that in the limit that the closest approach distance $x_{min} \gg r$, the radius of a particle ring, the fractional change in angular momentum scales as $(x_{min}/r)^{-5}$. This asymptotic limit ensures that the cumulative effect of distant encounters is minor in terms of its influence on disc evolution. The angular momentum transfer is dominated by the $m=2$ Lindblad resonance for closer encounters and by the $m=1$, $\omega = 0$ Lindblad resonance at large $x_{min}/r$. We contextualise these results by comparing expected angular momentum loss for the outer edge of a PPD due to distant and close encounters. Contrary to the suggestions of previous works we do not find that distant encounters contribute significantly to angular momentum loss in PPDs. We define an upper limit for closest approach distance where interactions are significant as a function of arbitrary host to perturber mass ratio $M_2/M_1$

Risk of Cerebrovascular Events in 178 962 Five-Year Survivors of Cancer Diagnosed at 15 to 39 Years of Age: The TYACSS (Teenage and Young Adult Cancer Survivor Study)

Background: Survivors of teenage and young adult (TYA) cancer are at risk of cerebrovascular events, but the magnitude of and extent to which this risk varies by cancer type, decade of diagnosis, age at diagnosis and attained age remains uncertain. This is the largest ever cohort study to evaluate the risks of hospitalisation for a cerebrovascular event among long-term survivors of TYA cancer. Methods:The population-based Teenage and Young Adult Cancer Survivor Study (N=178,962) was linked to Hospital Episode Statistics data for England to investigate the risks of hospitalisation for a cerebrovascular event among 5-year survivors of cancer diagnosed when aged 15-39 years. Observed numbers of first hospitalisations for cerebrovascular events were compared to that expected from the general population using standardised hospitalisation ratios (SHR) and absolute excess risks (AER) per 10,000 person-years. Cumulative incidence was calculated with death considered a competing risk. Results: Overall, 2,782 cancer survivors were hospitalised for a cerebrovascular event—40% higher than expected (SHR=1.4, 95% confidence interval [CI]=1.3-1.4). Survivors of central nervous system (CNS) tumours (SHR=4.6, CI=4.3-5.0), head & neck tumours (SHR=2.6, CI=2.2-3.1) and leukaemia (SHR=2.5, CI=1.9-3.1) were at greatest risk. Males had a significantly higher AER than females (AER=7 versus 3), especially among head & neck tumour survivors (AER=30 versus 11). By age 60, 9%, 6% and 5% of CNS tumour, head & neck tumour, and leukaemia survivors, respectively, had been hospitalised for a cerebrovascular event. Beyond age 60, every year 0.4% of CNS tumour survivors were hospitalised for a cerebral infarction (versus 0.1% expected. Whereas at any age, every year 0.2% of head & neck tumour survivors were hospitalised for a cerebral infarction 7 (versus 0.06% expected). Conclusions: Survivors of a CNS tumour, head & neck tumour, and leukaemia are particularly at risk of hospitalisation for a cerebrovascular event. The excess risk of cerebral infarction among CNS tumour survivors increases with attained age. For head & neck tumour survivors this excess risk remains high across all ages. These groups of survivors, and in particular males, should be considered for surveillance of cerebrovascular risk factors and potential pharmacological interventions for cerebral infarction prevention

Gaze direction when driving after dark on main and residential roads: Where is the dominant location?

CIE JTC-1 has requested data regarding the size and shape of the distribution of drivers’ eye movement in order to characterise their visual adaptation. This article reports the eye movement of drivers along two routes in Berlin after dark, a main road and a residential street, captured using eye tracking. It was found that viewing behaviour differed between the two types of road. On the main road eye movement was clustered within a circle of approximately 10° diameter, centred at the horizon of the lane. On the residential street eye movement is clustered slightly (3.8°) towards the near side; eye movements were best captured with either an ellipse of approximate axes 10° vertical and 20° horizontal, centred on the lane ahead, or a 10° circle centred 3.8° towards the near side. These distributions reflect a driver’s tendency to look towards locations of anticipated hazards