Metronome-Cued Stepping in Place after Hemiparetic Stroke: Comparison of a One- and Two-Tone Beat

Hemiparetic gait is characterised by temporal asymmetry and variability, and these variables are improved by auditory cueing. Stepping in place incorporates aspects of gait and may be a useful tool for locomotor training. The aim of this pilot study was to investigate the use of a single-tone and dual-tone metronome to cue stepping in place after hemiparetic stroke. Eight participants completed an uncued baseline stepping condition and two cued stepping conditions utilising a single-tone and a dualtone metronome. Step times were determined from force plate data, and asymmetry and variability were calculated for the three conditions. Step time asymmetry was significantly reduced in the single-tone condition compared to baseline, and paretic step time variability was significantly reduced in both cued conditions.The single-tone metronome appeared to be preferred to the dual-tone metronome based on participant feedback.The results of this pilot study suggest that metronome cueing produces similar benefits on stepping in place to previously reported findings in walking. Further research on whether stepping in place to a metronome can be used for locomotor training is needed

Line Intensities and Molecular Opacities of the FeH F4Δi−X4ΔiF^4\Delta_i-X^4\Delta_i Transition

We calculate new line lists and opacities for the $F^4\Delta_i-X^4\Delta_i$ transition of FeH. The 0-0 band of this transition is responsible for the Wing-Ford band seen in M-type stars, sunspots and brown dwarfs. The new Einstein A values for each line are based on a high level ab initio calculation of the electronic transition dipole moment. The necessary rotational line strength factors (H\"onl-London factors) are derived for both the Hund's case (a) and (b) coupling limits. A new set of spectroscopic constants were derived from the existing FeH term values for v=0, 1 and 2 levels of the $X$ and $F$ states. Using these constants extrapolated term values were generated for v=3 and 4 and for $J$ values up to 50.5. The line lists (including Einstein A values) for the 25 vibrational bands with v$\leq$4 were generated using a merged list of experimental and extrapolated term values. The FeH line lists were use to compute the molecular opacities for a range of temperatures and pressures encountered in L and M dwarf atmospheres. Good agreement was found between the computed and observed spectral energy distribution of the L5 dwarf 2MASS-1507.Comment: 52 pages, 3 figures, many tables, accepted for publication in the Astrophysical Journal Supplement

Internal Disinhibition Predicts Weight Regain Following Weight Loss and Weight Loss Maintenance

Objective: The disinhibition scale of the Eating Inventory predicts weight loss outcome; however, it may include multiple factors. The purpose of this study was to examine the factor structure of the disinhibition scale and determine how its factors independently relate to long-term weight loss outcomes. Research Methods and Procedures: Exploratory factor analysis of the disinhibition scale was conducted on 286 participants in a behavioral weight loss trial (TRIM), and confirmatory factor analysis was conducted on 3345 members of the National Weight Control Registry (NWCR), a registry of successful weight loss maintainers. Multivariate regressions were used to examine the relationships between the disinhibition scale factors and weight over time in both samples. Results: Using baseline data from TRIM, two factors were extracted from the disinhibition scale: 1) an internal factor that described eating in response to internal cues, such as feelings and thoughts; and 2) an external factor that described eating in response to external cues, such as social events. This factor structure was confirmed using confirmatory factor analysis in the NWCR. In TRIM, internal disinhibition significantly predicted weight loss at 6 months (p = 0.03) and marginally significantly predicted weight loss at 18 months (p = 0.06), with higher levels of internal disinhibition at baseline predicting less weight loss; external disinhibition did not predict weight loss at any time-point. In NWCR, internal disinhibition significantly predicted one-year weight change (p = 0.001), while external disinhibition did not. Discussion: These results suggest that it is the disinhibition of eating in response to internal cues that is associated with poorer long-term weight loss outcomes

Inferring the Origin Locations of Tweets with Quantitative Confidence

Social Internet content plays an increasingly critical role in many domains, including public health, disaster management, and politics. However, its utility is limited by missing geographic information; for example, fewer than 1.6% of Twitter messages (tweets) contain a geotag. We propose a scalable, content-based approach to estimate the location of tweets using a novel yet simple variant of gaussian mixture models. Further, because real-world applications depend on quantified uncertainty for such estimates, we propose novel metrics of accuracy, precision, and calibration, and we evaluate our approach accordingly. Experiments on 13 million global, comprehensively multi-lingual tweets show that our approach yields reliable, well-calibrated results competitive with previous computationally intensive methods. We also show that a relatively small number of training data are required for good estimates (roughly 30,000 tweets) and models are quite time-invariant (effective on tweets many weeks newer than the training set). Finally, we show that toponyms and languages with small geographic footprint provide the most useful location signals.Comment: 14 pages, 6 figures. Version 2: Move mathematics to appendix, 2 new references, various other presentation improvements. Version 3: Various presentation improvements, accepted at ACM CSCW 201

An Economic Analysis of Twitching Behaviour and Species Rarity

Avid birdwatchers, or ‘twitchers’, expend a considerable amount of money and time pursuing viewing experiences of rare or vagrant species. By vagrant species we mean a species found outside its normal range/distribution. To enhance our understanding of this form of behaviour, we present results from a UK survey of twitchers. First, we examine the relationship between cost and rarity based on actual viewing experiences. Our statistical results reveal that the relationship between cost and rarity is positive and very inelastic. Second, we present results from a hypothetical Best-Worst Scaling exercise examining aspects of species rarity. We find that rarity is a more nuanced construct than simply the frequency with which a vagrant species has appeared. Our results provide insights into the meaning of rarity, as well as the economic value attach to it and why

Maternal postpartum depression is a risk factor for infant emotional variability at 4 months

Maternal postpartum depression (PPD) is a risk for disruption of mother–infant interaction. Infants of depressed mothers have been found to display less positive, more negative, and neutral affect. Other studies have found that infants of mothers with PPD inhibit both positive and negative affect. In a sample of 28 infants of mothers with PPD and 52 infants of nonclinical mothers, we examined the role of PPD diagnosis and symptoms for infants’ emotional variability, measured as facial expressions, vocal protest, and gaze using microanalysis, during a mother–infant face-to-face interaction. PPD symptoms and diagnosis were associated with (a) infants displaying fewer high negative, but more neutral/interest facial affect events, and (b) fewer gaze off events. PPD diagnosis, but not symptoms, was associated with less infant vocal protest. Total duration of seconds of infant facial affective displays and gaze off was not related to PPD diagnosis or symptoms, suggesting that when infants of depressed mothers display high negative facial affect or gaze off, these expressions are more sustained, indicating lower infant ability to calm down and re-engage, interpreted as a disturbance in self-regulation. The findings highlight the importance of not only examining durations, but also frequencies, as the latter may inform infant emotional variability

Understanding psychiatric institutionalization: a conceptual review

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for hypertension in the elderly

Copyright © 2003 Massachusetts Medical Society. All rights reserved.Background Treatment of hypertension with diuretics, beta-blockers, or both leads to improved outcomes. It has been postulated that agents that inhibit the renin–angiotensin system confer benefit beyond the reduction of blood pressure alone. We compared the outcomes in older subjects with hypertension who were treated with angiotensin-converting–enzyme (ACE) inhibitors with the outcomes in those treated with diuretic agents. Methods We conducted a prospective, randomized, open-label study with blinded assessment of end points in 6083 subjects with hypertension who were 65 to 84 years of age and received health care at 1594 family practices. Subjects were followed for a median of 4.1 years, and the total numbers of cardiovascular events in the two treatment groups were compared with the use of multivariate proportional-hazards models. Results At base line, the treatment groups were well matched in terms of age, sex, and blood pressure. By the end of the study, blood pressure had decreased to a similar extent in both groups (a decrease of 26/12 mm Hg). There were 695 cardiovascular events or deaths from any cause in the ACE-inhibitor group (56.1 per 1000 patient-years) and 736 cardiovascular events or deaths from any cause in the diuretic group (59.8 per 1000 patient-years; the hazard ratio for a cardiovascular event or death with ACE-inhibitor treatment was 0.89 [95 percent confidence interval, 0.79 to 1.00]; P=0.05). Among male subjects, the hazard ratio was 0.83 (95 percent confidence interval, 0.71 to 0.97; P=0.02); among female subjects, the hazard ratio was 1.00 (95 percent confidence interval, 0.83 to 1.21; P=0.98); the P value for the interaction between sex and treatment-group assignment was 0.15. The rates of nonfatal cardiovascular events and myocardial infarctions decreased with ACE-inhibitor treatment, whereas a similar number of strokes occurred in each group (although there were more fatal strokes in the ACE-inhibitor group). Conclusions Initiation of antihypertensive treatment involving ACE inhibitors in older subjects, particularly men, appears to lead to better outcomes than treatment with diuretic agents, despite similar reductions of blood pressure.Lindon M.H. Wing, Christopher M. Reid, Philip Ryan, Lawrence J. Beilin, Mark A. Brown, Garry L.R. Jennings, Colin I. Johnston, John J. McNeil, Graham J. Macdonald, John E. Marley, Trefor O. Morgan, and Malcolm J. West, for the Second Australian National Blood Pressure Study Grou

STU Black Holes and String Triality

We find double-extreme black holes associated with the special geometry of the Calabi-Yau moduli space with the prepotential F=STU. The area formula is STU-moduli independent and has ${[SL(2,Z)]}^3$ symmetry in space of charges. The dual version of this theory without prepotential treats the dilaton S asymmetric versus T,U-moduli. We display the dual relation between new (STU) black holes and stringy (S|TU) black holes using particular Sp(8, Z) transformation. The area formula of one theory equals that of the dual theory when expressed in terms of dual charges. We analyse the relation between (STU) black holes to string triality of black holes: (S|TU), (T|US), (U|ST) solutions. In the democratic STU-symmetric version we find that all three S and T and U duality symmetries are non-perturbative and mix electric and magnetic charges.Comment: 12 pages, 2 Postscript figures, ref.added, minor corrections, version to appear in Phys. Rev.