9,511 research outputs found
Global Standards in Action: Insights from Anti-Money Laundering Regulation
As organizations have come under the increasing influence of global rules of all sorts, organization scholars have started studying the dynamics of global regulation. The purpose of this article is to identify and evaluate the contribution to this interdisciplinary field by the âStockholm Centre for Organisational Researchâ. The latterâs key proposition is that while global regulation often consists of voluntary best practice rules it can nevertheless become highly influential under certain conditions. We assess how innovative this approach is using as a benchmark the state of the art in another field of relevance to the study of global regulation, i.e. âInternational Relationsâ. Our discussion is primarily theoretical but we draw on the case of global anti-money laundering regulation to illustrate our arguments and for inspirations of how to further elaborate the approach
Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer?
A negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on clinical characteristics may remain at unacceptably high risk of axillary disease even after a negative SLN biopsy result. A Bayesian nomogram was designed to combine the probability of axillary disease prior to nodal biopsy with customized test characteristics for an SLN biopsy and provides the probability of axillary disease despite a negative SLN biopsy. Users may individualize the sensitivity of an SLN biopsy based on factors known to modify the sensitivity of the procedure. This tool may be useful in identifying patients who should have expanded upfront exploration of the axilla or comprehensive axillary irradiation
Frequency decoding of periodically timed action potentials through distinct activity patterns in a random neural network
Frequency discrimination is a fundamental task of the auditory system. The
mammalian inner ear, or cochlea, provides a place code in which different
frequencies are detected at different spatial locations. However, a temporal
code based on spike timing is also available: action potentials evoked in an
auditory-nerve fiber by a low-frequency tone occur at a preferred phase of the
stimulus-they exhibit phase locking-and thus provide temporal information about
the tone's frequency. In an accompanying psychoacoustic study, and in agreement
with previous experiments, we show that humans employ this temporal information
for discrimination of low frequencies. How might such temporal information be
read out in the brain? Here we demonstrate that recurrent random neural
networks in which connections between neurons introduce characteristic time
delays, and in which neurons require temporally coinciding inputs for spike
initiation, can perform sharp frequency discrimination when stimulated with
phase-locked inputs. Although the frequency resolution achieved by such
networks is limited by the noise in phase locking, the resolution for realistic
values reaches the tiny frequency difference of 0.2% that has been measured in
humans.Comment: 16 pages, 5 figures, and supplementary informatio
Instrumentation-related uncertainty of reflectance and transmittance measurements with a two-channel spectrophotometer
Spectrophotometers are operated in numerous fields of science and industry for a variety of applications. In order to provide confidence for the measured data, analyzing the associated uncertainty is valuable. However, the uncertainty of the measurement results is often unknown or reduced to sample-related contributions. In this paper, we describe our approach for the systematic determination of the measurement uncertainty of the commercially available two-channel spectrophotometer Agilent Cary 5000 in accordance with the Guide to the expression of uncertainty in measurements. We focus on the instrumentation-related uncertainty contributions rather than the specific application and thus outline a general procedure which can be adapted for other instruments. Moreover, we discover a systematic signal deviation due to the inertia of the measurement amplifier and develop and apply a correction procedure. Thereby we increase the usable dynamic range of the instrument by more than one order of magnitude. We present methods for the quantification of the uncertainty contributions and combine them into an uncertainty budget for the device. © 2017 Author(s)
Reference Distorted Prices
I show that when consumers (mis)perceive prices relative to reference prices,
budgets turn out to be soft, prices tend to be lower and the average quality of
goods sold decreases. These observations provide explanations for decentralized
purchase decisions, for people being happy with a purchase even when they have
paid their evaluation, and for why trade might affect high quality local firms
'unfairly'
Development of intuitive rules: Evaluating the application of the dual-system framework to understanding children's intuitive reasoning
This is an author-created version of this article. The original source of publication is Psychon Bull Rev. 2006 Dec;13(6):935-53
The final publication is available at www.springerlink.com
Published version: http://dx.doi.org/10.3758/BF0321390
Aromatase inhibitors as adjuvant therapy for postmenopausal women: a therapeutic advance but many unresolved questions
Adjuvant hormonal therapy for postmenopausal women with early stage breast cancer has become far more complex over the past several years. This commentary reviews the current status of the five major trials evaluating the use of the aromatase inhibitors in the adjuvant setting. The data currently available suggest that the aromatase inhibitors are efficacious either as upfront therapy or after a course of tamoxifen. Ongoing trials will compare these approaches and guide the use of these agents in the years to come
The Privateness of Public Expenditure with Application to Indian States
Governments provide private goods as well as public services. We present a model of the
private good - public good mix in public expenditure, and then apply it to explain the
composition of spending by Indian state governments. The model explains why the publically
provided private good to public good ratio is a decreasing function of the real income of voters,
and is also decreasing in the degree of political competition. These hypotheses are tested on a
panel of 14 Indian states for fiscal years 1987/88 to 2011/12. The long run results of three
alternative ARDL models are broadly consistent with the proposed hypotheses, particularly the
relationship between the private good share of state expenditures and real per capita incomes.
They suggest that rising incomes and more effective political competi
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