1,340 research outputs found

    'Better as a Buddhist': an interpretative phenomenological analysis of the reflections on the religious beliefs of Buddhist men serving a prison sentence for a sexual offence

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    This paper presents a qualitative analysis of the accounts offered by individuals (n=7) convicted of a sexual offence who describe themselves as Buddhists. Data were collected through semi-structured interviews within a custodial environment and analysed using interpretative phenomenological analysis (IPA). This paper presents the two superordinate themes that emerged from the data: (i) Better as a Buddhist and (ii) Ebb and Flow. Reflections and analysis from the Buddhist prison chaplain are integrated within the analysis of prisoner-participant data. Implications of the analysis are discussed with reference to interventions that use Buddhist principles, factors that underpin factors that help reduce reoffending and those that fit with the formation of a desistance narrative for religious individuals who have committed sexual offences

    Norovirus: an overview of virology and preventative measures

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    Norovirus (NoV) is an enteric non-enveloped virus which is the leading cause of gastroenteritis across all age groups. It is responsible for around 200,000 deaths annually and outbreaks are common in small communities such as educational and care facilities. 40% of all NoV outbreaks occur in long-term and acute-care facilities, forming the majority of outbreaks. Nosocomial settings set ideal environments for ease of transmission, especially due to the presence of immunocompromised groups. It is estimated to cost global economies around ÂŁ48 billion a year, making it a global issue. NoV is transmitted via the faecal-oral route and infection with it results in asymptomatic cases or gastrointestinal disease. It has high mutational rates and this allows for new variants to emerge and be more resistant. The classification system available divides NoV into 10 genogroups and 49 genotypes based on whole amino acid sequencing of VP1 capsid protein and partial sequencing of RdRp, respectively. The most predominant genotypes which cause gastroenteritis in humans include GI.1 and GII.4, where GII.4 is responsible for more extreme clinical implications such as hospitalisation. In addition, GII.4 has been responsible for 6 pandemic strains, the last of which is the GII.4 Sydney (2012) variant. In recent years, the successful cultivation of HuNoV was reported in stem cell-derived human intestinal enteroids (HIEs), which promises to assist in giving a deeper understanding of its underlying mechanisms of infection and the development of more personalized control measures. There are no specific control measures against NoV, therefore common practices are used against it such as hand washing. No vaccine is available, but the HIL-214 candidate passed clinical phase 2b and shows promise

    Oncolytic virotherapy treatment of breast cancer : barriers and recent advances

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    Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism of action is two-fold: direct cell lysis and unmasking of the cancer through immunogenic cell death, which allows the immune system to recognize and eradicate tumours. Breast cancer is the most common cancer in women and is challenging to treat with immunotherapy modalities because it is classically an immunogenically “cold” tumour type. This provides an attractive niche for OV, given viruses have been shown to turn “cold” tumours “hot,” thereby opening a plethora of treatment opportunities. There has been a number of pre-clinical attempts to explore the use of OV in breast cancer; however, these have not led to any meaningful clinical trials. This review considers both the potential and the barriers to OV in breast cancer, namely, the limitations of monotherapy and the scope for combination therapy, improving viral delivery and challenges specific to the breast cancer population (e.g., tumour subtype, menopausal status, age)

    Early Iron Deficiency Stress Response in Leaves of Sugar Beet

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