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Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study.
BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease. However, intrapartum antibiotic prophylaxis does not prevent maternal sepsis, premature births, stillbirths or late-onset disease. Maternal vaccination may offer an alternative strategy. Multivalent polysaccharide protein conjugate vaccine development is under way and a serocorrelate of protection is needed to expedite vaccine licensure. OBJECTIVES: The ultimate aim of this work is to determine the correlate of protection against the major group B streptococcus disease-causing serotypes in infants in the UK. The aim of this feasibility study is to test key operational aspects of the study design. DESIGN: Prospective cohort study of pregnant women and their infants in a 6-month period (1 July to 31 December 2018). SETTING: Five secondary and tertiary hospitals from London and South England. National iGBS disease surveillance was conducted in all trusts in England and Wales. PARTICIPANTS: Pregnant women aged â„â18 years who were delivering at one of the selected hospitals and who provided consent during the study period. There were no exclusion criteria. INTERVENTIONS: No interventions were performed. MAIN OUTCOME MEASURES: (1) To test the feasibility of collecting serum at delivery from a large cohort of pregnant women. (2) To test the key operational aspects for a proposed large serocorrelates study. (3) To test the feasibility of collecting samples from those with invasive group B streptococcus. RESULTS: A total of 1823 women were recruited during the study period. Overall, 85% of serum samples were collected at three sites collecting only cord blood. At the two sites collecting maternal, cord and infant blood samples, the collection rate was 60%. A total of 614 women were screened for group B streptococcus with a colonisation rate of 22% (serotype distribution: 30% III, 25% Ia, 16% II, 14% Ib, 14% V and 1% IV). A blood sample was collected from 34 infants who were born to colonised women. Maternal and infant blood and the bacterial isolates for 15 newborns who developed invasive group B streptococcal disease during the study period were collected (serotype distribution: 29% III, 29% II, 21% Ia, 7% Ib, 7% IV and 7% V). LIMITATIONS: Recruitment and sample collection were dependent on the presence of research midwives rather than the whole clinical team. In addition, individualised consent limited the number of women who could be approached each day, and site set-up for the national surveillance study and the limited time period of this feasibility study limited recruitment of all eligible participants. CONCLUSIONS: We have verified the feasibility of collecting and processing rectovaginal swabs and blood samples in pregnant women, as well as samples from those with invasive group B streptococcal disease. We have made recommendations for the recruitment of cases within the proposed GBS3 study and for controls both within GBS3 and as an extension of this feasibility study. FUTURE WORK: A large case-control study comparing specific immunoglobulin G levels in mothers whose infants develop invasive group B streptococcal disease with those in colonised mothers whose infants do not develop invasive group B streptococcal disease is recommended. TRIAL REGISTRATION: Current Controlled Trials ISRCTN49326091; IRAS project identification number 246149/REC reference number 18/WM/0147. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 67. See the NIHR Journals Library website for further project information
Predators in Natural Fragments: Foraging Ecology of Wolves in British Columbiaâs Central and North Coast Archipelago
Aim Predatorâprey dynamics in fragmented areas may be influenced by spatial features of the landscape. Although little is known about these processes, an increasingly fragmented planet underscores the urgency to predict its consequences. Accordingly, our aim was to examine foraging behaviour of an apex mammalian predator, the wolf (Canis lupus), in an archipelago environment.
Location Mainland and adjacent archipelago of British Columbia, Canada; a largely pristine and naturally fragmented landscape with islands of variable size and isolation.
Methods We sampled 30 mainland watersheds and 29 islands for wolf faeces in summers 2000 and 2001 and identified prey remains. We examined broad geographical patterns and detailed biogeographical variables (area and isolation metrics) as they relate to prey consumed. For island data, we used Akaike Information Criteria to guide generalized linear regression model selection to predict probability of black-tailed deer (main prey; Odocoileus hemionus) in faeces.
Results Black-tailed deer was the most common item in occurrence per faeces (63%) and occurrence per item (53%) indices, representing about 63% of mammalian biomass. Wolves consumed more deer on islands near the mainland (65% occurrence per item) than on the mainland (39%) and outer islands (45%), where other ungulates (mainland only) and small mammals replaced deer. On islands, the probability of detecting deer was influenced primarily by island distance to mainland (not by area or inter-landmass distance), suggesting limited recolonization by deer from source populations as a causal mechanism.
Main conclusions Although sampling was limited in time, consistent patterns among islands suggest that population dynamics in isolated fragments are less stable and can result in depletion of prey. This may have important implications in understanding predatorâprey communities in isolation, debate regarding wolfâ deer systems and logging in temperate rain forests, and reserve design
The Impact of Border Carbon Adjustments under Alternative Producer Responses
Abstract and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/)Border carbon adjustments (BCAs) have been proposed to address leakage and competitiveness concerns. In traditional assessments, firms regard BCAs as output taxes rather than implicit emissions taxes. Using a stylized energy-economic model, we analyze the impact of BCAs for alternative producer responses. When firms view BCAs as an implicit emissions tax, the outcome depends on whether or not firms can differentiate production across destination markets. If firms are able to produce a low-emissions variety for regions imposing BCAs, results are similar to when firms regard BCAs as an output tax. If firms produce a single variety for all markets, BCAs result in larger leakage reductions than in standard approaches. We also find that BCAs are less effective at addressing competitive concerns in scenarios that result in larger leakage reductions.This study received support from the MIT Joint Program on the Science and Policy of Global Change, which is funded by a consortium of government, industry and foundation sponsors
Effect of nucleon exchange on projectile multifragmentation in the reactions of 28Si + 112Sn and 124Sn at 30 and 50 MeV/nucleon
Multifragmentation of quasiprojectiles was studied in reactions of 28Si beam
with 112Sn and 124Sn targets at projectile energies 30 and 50 MeV/nucleon. The
quasiprojectile observables were reconstructed using isotopically identified
charged particles with Z_f <= 5 detected at forward angles. The nucleon
exchange between projectile and target was investigated using isospin and
excitation energy of reconstructed quasiprojectile. For events with total
reconstructed charge equal to the charge of the beam (Z_tot = 14) the influence
of beam energy and target isospin on neutron transfer was studied in detail.
Simulations employing subsequently model of deep inelastic transfer,
statistical model of multifragmentation and software replica of FAUST detector
array were carried out. A concept of deep inelastic transfer provides good
description of production of highly excited quasiprojectiles. The isospin and
excitation energy of quasiprojectile were described with good overall
agreement. The fragment multiplicity, charge and isospin were reproduced
satisfactorily. The range of contributing impact parameters was determined
using backtracing procedure.Comment: 11 pages, 8 Postscript figures, LaTeX, to appear in Phys. Rev. C (
Dec 2000
Introduction: looking beyond the walls
In its consideration of the remarkable extent and variety of non-university researchers, this book takes a broader view of âknowledgeâ and âresearchâ than in the many hot debates about todayâs knowledge society, âlearning ageâ, or organisation of research. It goes beyond the commonly held image of âknowledgeâ as something produced and owned by the full-time experts to take a look at those engaged in active knowledge building outside the university walls
Evaluation Of Elastic Modulus And Stress Gradient Of PECVD Silicon Nitride Thin Films
This study investigated the techniques for determining the elastic modulus and estimating the stress gradient of plasma-enhanced chemical vapor deposition (PECVD) silicon nitride thin films. The experimentally determined elastic modulus was then used in a finite element beam model to compute the stress distribution inside the thin films using a commercial finite element analysis package. The computed beam displacement caused by a given stress gradient was compared with the displacement experimentally evaluated using optical interference microscopy. This comparison allows the stress gradient of the PECVD silicon nitride membrane introduced by the fabrication process to be evaluated
Tracing the Evolution of Temperature in Near Fermi Energy Heavy Ion Collisions
The kinetic energy variation of emitted light clusters has been employed as a
clock to explore the time evolution of the temperature for thermalizing
composite systems produced in the reactions of 26A, 35A and 47A MeV Zn
with Ni, Mo and Au. For each system investigated, the
double isotope ratio temperature curve exhibits a high maximum apparent
temperature, in the range of 10-25 MeV, at high ejectile velocity. These
maximum values increase with increasing projectile energy and decrease with
increasing target mass. The time at which the maximum in the temperature curve
is reached ranges from 80 to 130 fm/c after contact. For each different target,
the subsequent cooling curves for all three projectile energies are quite
similar. Temperatures comparable to those of limiting temperature systematics
are reached 30 to 40 fm/c after the times corresponding to the maxima, at a
time when AMD-V transport model calculations predict entry into the final
evaporative or fragmentation stage of de-excitation of the hot composite
systems. Evidence for the establishment of thermal and chemical equilibrium is
discussed.Comment: 9 pages, 5 figure
Properties of the Initial Participant Matter Interaction Zone in Near Fermi-Energy Heavy Ion Collisions
The sizes, temperatures and free neutron to proton ratios of the initial
interaction zones produced in the collisions of 40 MeV/nucleon Ar +
Sn and 55 MeV/nucleonAl + Sn are derived using total
detected neutron plus charged particle multiplicity as a measure of the impact
parameter range and number of participant nucleons. The size of the initial
interaction zone, determined from a coalescence model analysis, increases
significantly with decreasing impact parameter. The temperatures and free
neutron to proton ratios in the interaction zones are relatively similar for
different impact parameter ranges and evolve in a similar fashion.Comment: 7 pages, 8 figure
Evidence of Critical Behavior in the Disassembly of Nuclei with A ~ 36
A wide variety of observables indicate that maximal fluctuations in the
disassembly of hot nuclei with A ~ 36 occur at an excitation energy of 5.6 +-
0.5 MeV/u and temperature of 8.3 +- 0.5 MeV. Associated with this point of
maximal fluctuations are a number of quantitative indicators of apparent
critical behavior. The associated caloric curve does not appear to show a
flattening such as that seen for heavier systems. This suggests that, in
contrast to similar signals seen for liquid-gas transitions in heavier nuclei,
the observed behavior in these very light nuclei is associated with a
transition much closer to the critical point.Comment: v2: Major changes, new model calculations, new figure
Critical Behavior in Light Nuclear Systems: Experimental Aspects
An extensive experimental survey of the features of the disassembly of a
small quasi-projectile system with 36, produced in the reactions of 47
MeV/nucleon Ar + Al, Ti and Ni, has been carried
out. Nuclei in the excitation energy range of 1-9 MeV/u have been investigated
employing a new method to reconstruct the quasi-projectile source. At an
excitation energy 5.6 MeV/nucleon many observables indicate the presence
of maximal fluctuations in the de-excitation processes. The fragment
topological structure shows that the rank sorted fragments obey Zipf's law at
the point of largest fluctuations providing another indication of a liquid gas
phase transition. The caloric curve for this system shows a monotonic increase
of temperature with excitation energy and no apparent plateau. The temperature
at the point of maximal fluctuations is MeV. Taking this
temperature as the critical temperature and employing the caloric curve
information we have extracted the critical exponents , and
from the data. Their values are also consistent with the values of the
universality class of the liquid gas phase transition. Taken together, this
body of evidence strongly suggests a phase change in an equilibrated mesoscopic
system at, or extremely close to, the critical point.Comment: Physical Review C, in press; some discussions about the validity of
excitation energy in peripheral collisions have been added; 24 pages and 32
figures; longer abstract in the preprin
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