Analysis of Push-Up and Pull-Up Variants to Develop an Upper Extremity Model

Musculoskeletal Injuries are the most common cause of severe long-term pain and physical disability. Push-Ups and Pull-Ups are effective dynamic exercises that mimic high level function activities, such as those used in the military. The model developed allows for researchers to analyze the forces and moments associated with the shoulder, elbow and wrist, to further assess function in military personnel, athletes and the active population. The model also follows the guidelines set forth by the International Society of Biomechanics (ISB)

Protocol for Rapid Assessment of the Efficacy of Novel Wnt Inhibitors Using Zebrafish Models

Dysregulation of Wnt signaling is a hallmark of many cancers, and the development of effective, non-toxic small-molecule Wnt inhibitors is desirable. Off-target toxicities of new compounds are typically tested in mouse models, which is both costly and time consuming. Here, we present a rapid and inexpensive protocol to determine the in vivo toxicity and efficacy of novel Wnt inhibitors in zebrafish using a combination of a fluorescence reporter assay as well as eye rescue and fin regeneration assays. These experiments are completed within 1 week to rapidly narrow drug candidates before moving to more expensive pre-clinical testing. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2020)

Is the routine health information system ready to support the planned national health insurance scheme in South Africa?

Implementation of a National Health Insurance (NHI) in South Africa requires a reliable, standardized health information system that supports Diagnosis-Related Groupers for reimbursements and resource management. We assessed the quality of inpatient health records, the availability of standard discharge summaries and coded clinical data and the congruence between inpatient health records and discharge summaries in public-sector hospitals to support the NHI implementation in terms of reimbursement and resource management. We undertook a cross-sectional healthrecords review from 45 representative public hospitals consisting of seven tertiary, 10 regional and 28 district hospitals in 10 NHI pilot districts representing all nine provinces. Data were abstracted from a randomly selected sample of 5795 inpatient health records from the surgical, medical, obstetrics and gynaecology, paediatrics and psychiatry departments. Quality was assessed for 10 pre-defined data elements relevant to NHI reimbursements, by comparing information in source registers, patient folders and discharge summaries for patients admitted in March and July 2015

Moving nations: National and religious identity of people out-of-place. The Indonesian Christian Church in Perth

Identity is often theorised in Cultural Studies, but is less frequently contextualised and historicised. Much can be gained from examining identity formations through the micro-history of place. I have utilised the concept of Moving Nations to examine the formation of the Indonesian Christian Church (ICC) in Applecross, Western Australia. The term Moving Nations encompasses three key concepts. Firstly, the phrase denotes migration from one nation to another. Secondly, it encompasses the idea of moving a nation from one place to another, sometimes described as a migrant diaspora. Thirdly, the concept reveals the flexible, changeable and esoteric nature of national boundaries. Each of these notions impact upon, and frequently displace, the Subject. How do people negotiate the problem of Moving Nations? By probing the experiences of a specific community, and by drawing on my own experience in both migrating and living as a foreign national in another land, I have been able to investigate the questions posed through Moving Nations. I am indebted to ICC for the insight into migrant and diasporic politics. Defined both by nation and religion, discussion of ICC resonates with questions of identity. My own migration from England to Australia, and the year I spent studying in Indonesia during 1995-1996, also bring into play issues of Australian national identity and Whiteness. Pieced together, these elements form an image of Moving Nations, the microcosms which together create our post-modem society

Protocol for rapid assessment of the efficacy of novel Wnt inhibitors using zebrafish models

Summary: Dysregulation of Wnt signaling is a hallmark of many cancers, and the development of effective, non-toxic small-molecule Wnt inhibitors is desirable. Off-target toxicities of new compounds are typically tested in mouse models, which is both costly and time consuming. Here, we present a rapid and inexpensive protocol to determine the in vivo toxicity and efficacy of novel Wnt inhibitors in zebrafish using a combination of a fluorescence reporter assay as well as eye rescue and fin regeneration assays. These experiments are completed within 1 week to rapidly narrow drug candidates before moving to more expensive pre-clinical testing.For complete details on the use and execution of this protocol, please refer to Zhang et al. (2020)