347 research outputs found
Reaction-diffusion systems and nonlinear waves
The authors investigate the solution of a nonlinear reaction-diffusion
equation connected with nonlinear waves. The equation discussed is more general
than the one discussed recently by Manne, Hurd, and Kenkre (2000). The results
are presented in a compact and elegant form in terms of Mittag-Leffler
functions and generalized Mittag-Leffler functions, which are suitable for
numerical computation. The importance of the derived results lies in the fact
that numerous results on fractional reaction, fractional diffusion, anomalous
diffusion problems, and fractional telegraph equations scattered in the
literature can be derived, as special cases, of the results investigated in
this article.Comment: LaTeX, 16 pages, corrected typo
Solution of generalized fractional reaction-diffusion equations
This paper deals with the investigation of a closed form solution of a
generalized fractional reaction-diffusion equation. The solution of the
proposed problem is developed in a compact form in terms of the H-function by
the application of direct and inverse Laplace and Fourier transforms.
Fractional order moments and the asymptotic expansion of the solution are also
obtained.Comment: LaTeX, 18 pages, corrected typo
Fractional reaction-diffusion equations
In a series of papers, Saxena, Mathai, and Haubold (2002, 2004a, 2004b)
derived solutions of a number of fractional kinetic equations in terms of
generalized Mittag-Leffler functions which provide the extension of the work of
Haubold and Mathai (1995, 2000). The subject of the present paper is to
investigate the solution of a fractional reaction-diffusion equation. The
results derived are of general nature and include the results reported earlier
by many authors, notably by Jespersen, Metzler, and Fogedby (1999) for
anomalous diffusion and del-Castillo-Negrete, Carreras, and Lynch (2003) for
reaction-diffusion systems with L\'evy flights. The solution has been developed
in terms of the H-function in a compact form with the help of Laplace and
Fourier transforms. Most of the results obtained are in a form suitable for
numerical computation.Comment: LaTeX, 17 pages, corrected typo
The Proposed OECD Multilateral Instrument Amending Tax Treaties
In this article, the authors consider some of the practical issues relating to the introduction of the OECD multilateral instrument amending tax treaties, which has been proposed within the context of the OECD/G20 Base Erosion and Profit Shifting Project
WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies
The WRAP53 protein regulates the formation and maintenance of Cajal bodies (nuclear sub-organelles), as well as directs the recruitment of nuclear factors to Cajal bodies
Fibrinolysis in a lipid environment: modulation through release of free fatty acids
Background: Thrombolysis is conventionally regarded as dissolution of the fibrin matrix of thrombi by plasmin, but the structure of clots in vivo includes additional constituents (proteins, phospholipids) that modulate their solubilization. Objective: We examined the presence of free fatty acids in thrombi and their effects on distinct stages of fibrinolysis (plasminogen activation, plasmin activity). Methods and Results: Using the fluorescent probe acrylodated intestinal fatty acid-binding protein, variable quantities (up to millimolar concentrations) of free fatty acids were demonstrated in surgically removed human thrombi. Oleic acid at relevant concentrations reversibly inhibits more than 90% of the amidolytic activity of plasmin on a synthetic substrate (Spectrozyme PL), but only partially inhibits its fibrinolytic activity measured using turbidimetry. Chromogenic assays detecting the generated plasmin activity show that plasminogen activation by tissue-type plasminogen activator (t-PA) is completely blocked by oleic acid in the fluid phase, but is accelerated on a fibrin matrix. A recombinant derivative of t-PA (reteplase) develops higher fibrin specificity in the presence of oleic acid, because both the inhibition of plasminogen activation in free solution and its enhancement on fibrin template are stronger than with wild-type t-PA. Conclusion: Through the stimulation of plasminogen activation on a fibrin template and the inhibition of plasminogen activators and plasmin in the fluid phase, free fatty acids confine the action of fibrinolytic proteases to the site of clotting, where they partially oppose the thrombolytic barrier function of phospholipids
The A-B transition in superfluid helium-3 under confinement in a thin slab geometry
The influence of confinement on the topological phases of superfluid 3He is
studied using the torsional pendulum method. We focus on the phase transition
between the chiral A-phase and the time-reversal-invariant B-phase, motivated
by the prediction of a spatiallymodulated (stripe) phase at the A-B phase
boundary. We confine superfluid 3He to a single 1.08 {\mu}m thick nanofluidic
cavity incorporated into a high-precision torsion pendulum, and map the phase
diagram between 0.1 and 5.6 bar. We observe only small supercooling of the
A-phase, in comparison to bulk or when confined in aerogel. This has a
non-monotonic pressure dependence, suggesting that a new intrinsic B-phase
nucleation mechanism operates under confinement, mediated by the putative
stripe phase. Both the phase diagram and the relative superfluid fraction of
the A and B phases, show that strong coupling is present at all pressures, with
implications for the stability of the stripe phase.Comment: 6 figures, 1 table + supplemental informatio
High Resolution Genome-Wide Analysis of Chromosomal Alterations in Burkitt's Lymphoma
Additional chromosomal abnormalities are currently detected in Burkitt's lymphoma. They play major roles in the progression of BL and in prognosis. The genes involved remain elusive. A whole-genome oligonucleotide array CGH analysis correlated with karyotype and FISH was performed in a set of 27 Burkitt's lymphoma-derived cell lines and primary tumors. More than half of the 145 CNAs<2 Mb were mapped to Mendelian CNVs, including GSTT1, glutathione s-transferase and BIRC6, an anti-apoptotic protein, possibly predisposing to some cancers. Somatic cell line-specific CNVs localized to the IG locus were consistently observed with the 244 K aCGH platform. Among 136 CNAs >2 Mb, gains were found in 1q (12/27), 13q (7/27), 7q (6/27), 8q(4/27), 2p (3/27), 11q (2/27) and 15q (2/27). Losses were found in 3p (5/27), 4p (4/27), 4q (4/27), 9p (4/27), 13q (4/27), 6p (3/27), 17p (3/27), 6q (2/27),11pterp13 (2/27) and 14q12q21.3 (2/27). Twenty one minimal critical regions (MCR), (range 0.04–71.36 Mb), were delineated in tumors and cell lines. Three MCRs were localized to 1q. The proximal one was mapped to 1q21.1q25.2 with a 6.3 Mb amplicon (1q21.1q21.3) harboring BCA2 and PIAS3. In the other 2 MCRs, 1q32.1 and 1q44, MDM4 and AKT3 appeared as possible drivers of these gains respectively. The 13q31.3q32.1 <89.58–96.81> MCR contained an amplicon and ABCC4 might be the driver of this amplicon. The 40 Kb 2p16.1 <60.96–61> MCR was the smallest gained MCR and specifically encompassed the REL oncogene which is already implicated in B cell lymphomas. The most frequently deleted MCR was 3p14.1 <60.43–60.53> that removed the fifth exon of FHIT. Further investigations which combined gene expression and functional studies are essential to understand the lymphomagenesis mechanism and for the development of more effective, targeted therapeutic strategies
The iterated minimum modulus and conjectures of Baker and Eremenko
In transcendental dynamics significant progress has been made by studying points whose iterates escape to infinity at least as fast as iterates of the maximum modulus. Here we take the novel approach of studying points whose iterates escape at least as fast as iterates of the minimum modulus, and obtain new results related to Eremenko's conjecture and Baker's conjecture, and the rate of escape in Baker domains. To do this we prove a result of wider interest concerning the existence of points that escape to infinity under the iteration of a positive continuous function
Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer
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