Effects of Tillage and Residue Management on Soil Organic Carbon and Total Nitrogen in the North China Plain

Chinese Academy of Sciences XDA050500001 KSCX1-YW-09-06;Ministry of Science and Technology of China 2004CB720501A suitable tillage-residue management system is needed in the North China Plain (NCP) that sustains soil fertility and agronomic productivity. The objectives of this study were to determine the effects of different tillage-residue managements for a winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) double-crop system on soil organic carbon (SOC) and total N pools. No-tillage with residue cover (NTR), no-tillage with residue removed and manure applied (NTRRM), and conventional tillage with residue removed (CTRR) were investigated for 6 yr, based on a uniform N application among treatments. Soil samples were collected at six depths and changes in SOC and total N pools were analyzed. Treatments of NTRRM and NTR sequestered more SOC and total N in the 0- to 5-cm depth than CTRR. In the subsoil (5-60 cm), annual SOC sequestration was 0.01 and -0.40 Mg ha(-1) yr(-1) for NTRRM and NTR, respectively, while CTRR exhibited a significantly positive SOC pool trend. In the whole soil profile (0-60 cm), NTRRM, NTR, and CTRR sequestered SOC at the rates of 0.66, 0.27 and 2.24 Mg ha(-1) yr(-1). When manure was applied to substitute for the N lost from residue removal, the NTRRM tended to accumulate more SOC than NTR, and had similar accumulation as NTR in total N pools, grain yield, and aboveground biomass. Crop residue could be substituted by manure in this double-crop, irrigated system. Conventional tillage, with residue removed, was suitable in soil fertility and agronomic productivity relative to NTRRM and NTR in the NCP

SLN124, a GalNAc conjugated 19-mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers

SLN124, an N-acetylgalactosamine conjugated 19-mer short interfering RNA, is being developed to treat iron-loading anemias (including beta-thalassemia and myelodysplastic syndromes) and myeloproliferative neoplasms (polycythemia vera). Through hepatic targeting and silencing of the TMPRSS6 gene, SLN124 increases endogenous hepcidin synthesis. This is the first clinical report of an siRNA targeting a component of iron homeostasis. This first-in-human, phase 1 study assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of SLN124 (1.0, 3.0, and 4.5 mg/kg) in healthy volunteers. Twenty-four participants were randomized in three sequential cohorts of eight subjects, each to receive a single dose of either SLN124 or placebo (6:2 randomization), administered subcutaneously. There were no serious or severe adverse events, or discontinuations due to adverse events, and most treatment-emergent adverse events were mild, including transient mild injection site reactions, resolving without intervention. SLN124 was rapidly absorbed, with a median tmax of 4–5 h across all treatment groups, and largely eliminated from plasma by 48 h. Plasma concentrations increased in a greater than dose proportional fashion between treatment groups. In all SLN124 groups, a dose-related effect was observed across iron metabolism markers, and across erythroid markers, SLN124 resulted in increased plasma hepcidin levels, peaking around Day 29, and consequent dose-related sustained reductions in plasma iron and transferrin saturation with decreased reticulocyte production, MCHC, and MCV. Results suggest duration of action lasting up to 56 days after a single SLN124 dose, on hepcidin and hematological parameters of iron metabolism (serum iron and TSAT)

Vitellogenin Underwent Subfunctionalization to Acquire Caste and Behavioral Specific Expression in the Harvester Ant Pogonomyrmex barbatus

PMCID: PMC3744404This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication

Observation of He-like satellite lines of the H-like potassium K XIX emission

We present measurements of the H-like potassium (K XIX) X-ray spectrum and its Helike (K XVIII) satellite lines, which are situated in the wavelength region between 3.34 and 3.39 Å, which has been of interest for the detection of dark matter. The measurements were taken with a high-resolution X-ray spectrometer from targets irradiated by a long-pulse (2 ns) beam from the Orion laser facility. We obtain experimental wavelength values of dielectronic recombination satellite lines and show that the ratio of the Lyα lines and their dielectronic satellite lines can be used to estimate the electron temperature, which in our case was about 1.5±0.3 keV

Enhanced fluorescence from X-Ray line coincidence pumping

Many resonant photo-pumped X-ray laser schemes that use a strong pump line such as Ly-α or He-α to populate the upper laser state of a separate lasing material have been proposed over the last four decades but none have been demonstrated. As a first step to creating a photo-pumped X-ray laser we have decided to reinvestigate some of these schemes at the Orion laser facility with the goal to show enhanced fluorescence. In particular we look at using the Ly-α or He-α K lines to pump the 1s–3p and 4p transitions in H-like Cl and see fluorescence on the 4f–3d line at 65 Å and the 3d–2p line at 23 Å. Preliminary experiments are presented that show a modest enhancement. As an alternative we also look at enhancing the 2p–2s line in Ne-like Ge at 65 Å using the Ly-α Mg line to photo-pump the 2s–3p line of Ne-like Ge. Calculations are presented that suggest modest enhancements of 2.5

Cavity formation on the surface of a body entering water with deceleration

The two-dimensional water entry of a rigid symmetric body with account for cavity formation on the body surface is studied. Initially the liquid is at rest and occupies the lower half plane. The rigid symmetric body touches the liquid free surface at a single point and then starts suddenly to penetrate the liquid vertically with a time-varying speed. We study the effect of the body deceleration on the pressure distribution in the flow region. It is shown that, in addition to the high pressures expected from the theory of impact, the pressure on the body surface can later decrease to sub-atmospheric levels. The creation of a cavity due to such low pressures is considered. The cavity starts at the lowest point of the body and spreads along the body surface forming a thin space between a new free surface and the body. Within the linearised hydrodynamic problem, the positions of the two turnover points at the periphery of the wetted area are determined by Wagner’s condition. The ends of the cavity’s free surface are modelled by the Brillouin–Villat condition. The pressure in the cavity is assumed to be a prescribed constant, which is a parameter of the model. The hydrodynamic problem is reduced to a system of integral and differential equations with respect to several functions of time. Results are presented for constant deceleration of two body shapes: a parabola and a wedge. The general formulation made also embraces conditions where the body is free to decelerate under the total fluid force. Contrasts are drawn between results from the present model and a simpler model in which the cavity formation is suppressed. It is shown that the expansion of the cavity can be significantly slower than the expansion of the corresponding zone of sub-atmospheric pressure in the simpler model. For forced motion and cavity pressure close to atmospheric, the cavity grows until almost complete detachment of the fluid from the body. In the problem of free motion of the body, cavitation with vapour pressure in the cavity is achievable only for extremely large impact velocities

Expression of Drug Targets in Patients Treated with Sorafenib, Carboplatin and Paclitaxel

Introduction: Sorafenib, a multitarget kinase inhibitor, targets members of the mitogen-activated protein kinase (MAPK) pathway and VEGFR kinases. Here we assessed the association between expression of sorafenib targets and biomarkers of taxane sensitivity and response to therapy in pre-treatment tumors from patients enrolled in ECOG 2603, a phase III comparing sorafenib, carboplatin and paclitaxel (SCP) to carboplatin, paclitaxel and placebo (CP). Methods: Using a method of automated quantitative analysis (AQUA) of in situ protein expression, we quantified expression of VEGF-R2, VEGF-R1, VEGF-R3, FGF-R1, PDGF-Rβ, c-Kit, B-Raf, C-Raf, MEK1, ERK1/2, STMN1, MAP2, EB1 and Bcl-2 in pretreatment specimens from 263 patients. Results: An association was found between high FGF-R1 and VEGF-R1 and increased progression-free survival (PFS) and overall survival (OS) in our combined cohort (SCP and CP arms). Expression of FGF-R1 and VEGF-R1 was higher in patients who responded to therapy ((CR+PR) vs. (SD+PD+ un-evaluable)). Conclusions: In light of the absence of treatment effect associated with sorafenib, the association found between FGF-R1 and VEGF-R1 expression and OS, PFS and response might reflect a predictive biomarker signature for carboplatin/paclitaxel-based therapy. Seeing that carboplatin and pacitaxel are now widely used for this disease, corroboration in another cohort might enable us to improve the therapeutic ratio of this regimen. © 2013 Jilaveanu et al

Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD:implication for COPD-associated neuropathogenesis

The circadian timing system controls daily rhythms of physiology and behavior, and disruption of clock function can trigger stressful life events. Daily exposure to cigarette smoke (CS) can lead to alteration in diverse biological and physiological processes. Smoking is associated with mood disorders, including depression and anxiety. Patients with chronic obstructive pulmonary disease (COPD) have abnormal circadian rhythms, reflected by daily changes in respiratory symptoms and lung function. Corticosterone (CORT) is an adrenal steroid that plays a considerable role in stress and anti-inflammatory responses. Serotonin (5-hydroxytryptamine; 5HT) is a neurohormone, which plays a role in sleep/wake regulation and affective disorders. Secretion of stress hormones (CORT and 5HT) is under the control of the circadian clock in the suprachiasmatic nucleus. Since smoking is a contributing factor in the development of COPD, we hypothesize that CS can affect circadian rhythms of CORT and 5HT secretion leading to sleep and mood disorders in smokers and patients with COPD. We measured the daily rhythms of plasma CORT and 5HT in mice following acute (3 d), sub-chronic (10 d) or chronic (6 mo) CS exposure and in plasma from non-smokers, smokers and patients with COPD. Acute and chronic CS exposure affected both the timing (peak phase) and amplitude of the daily rhythm of plasma CORT and 5HT in mice. Acute CS appeared to have subtle time-dependent effects on CORT levels but more pronounced effects on 5HT. As compared with CORT, plasma 5HT was slightly elevated in smokers but was reduced in patients with COPD. Thus, the effects of CS on plasma 5HT were consistent between mice and patients with COPD. Together, these data reveal a significant impact of CS exposure on rhythms of stress hormone secretion and subsequent detrimental effects on cognitive function, depression-like behavior, mood/anxiety and sleep quality in smokers and patients with COPD