The endothelium solves problems that endothelial cells do not know exist

The endothelium is the single layer of cells that lines the entire cardiovascular system and that regulates vascular tone and blood-tissue exchange, recruits blood cells, modulates blood clotting and determines the formation of new blood vessels. To control each function, the endothelium uses a remarkable sensory capability to continuously monitor vanishingly small changes in the concentration of many simultaneously arriving extracellular activators that each provide cues to physiological state. Here, we suggest that the extraordinary sensory capabilities of the endothelium does not come from single cells but from the combined activity of a large number of endothelial cells. Each cell has a limited, but distinctive, sensory capacity and shares information with neighbours so that sensing is distributed among cells. Communication of information among connected cells provides a system-level sensing substantially greater than the capabilities of any single cell and, as a collective, the endothelium solves sensory problems too complex for any single cell

Spectroscopic Transit Search: a self-calibrating method for detecting planets around bright stars

We search for transiting exoplanets around the star $\beta$ Pictoris using high resolution spectroscopy and Doppler imaging that removes the need for standard star observations. These data were obtained on the VLT with UVES during the course of an observing campaign throughout 2017 that monitored the Hill sphere transit of the exoplanet $\beta$ Pictoris b. We utilize line profile tomography as a method for the discovery of transiting exoplanets. By measuring the exoplanet distortion of the stellar line profile, we remove the need for reference star measurements. We demonstrate the method with white noise simulations, and then look at the case of $\beta$ Pictoris, which is a $\delta$ Scuti pulsator. We describe a method to remove the stellar pulsations and perform a search for any transiting exoplanets in the resultant data set. We inject fake planet transits with varying orbital periods and planet radii into the spectra and determine the recovery fraction. In the photon noise limited case we can recover planets down to a Neptune radius with an $\sim$80% success rate, using an 8 m telescope with a $R\sim 100,000$ spectrograph and 20 minutes of observations per night. The pulsations of $\beta$ Pictoris limit our sensitivity to Jupiter-sized planets, but a pulsation removal algorithm improves this limit to Saturn-sized planets. We present two planet candidates, but argue that their signals are most likely caused by other phenomena. We have demonstrated a method for searching for transiting exoplanets that (i) does not require ancillary calibration observations, (ii) can work on any star whose rotational broadening can be resolved with a high spectral dispersion spectrograph and (iii) provides the lowest limits so far on the radii of transiting Jupiter-sized exoplanets around $\beta$ Pictoris with orbital periods from 15 days to 200 days with >50% coverage.Comment: Accepted for publication in A&A, 8 pages, 8 figures. The Github repository can be found at https://github.com/lennartvansluijs/Spectroscopic-Transit-Searc

Performance of an environmental test to detect Mycobacterium bovis infection in badger social groups

A study by Courtenay and others (2006) demonstrated that the probability of detecting Mycobacterium bovis by PCR in soil samples from the spoil heaps of main badger setts correlated with the prevalence of excretion (infectiousness) of captured badgers belonging to the social group. It has been proposed that such a test could be used to target badger culling to setts containing infectious animals (Anon 2007). This short communication discusses the issues surrounding this concept, with the intention of dispelling any misconceptions among relevant stakeholders (farmers, policy makers and conservationists)

Embedded point of care randomisation for evaluating comparative effectiveness questions: PROSPECTOR-critical care feasibility study protocol

INTRODUCTION: Many routinely administered treatments lack evidence as to their effectiveness. When treatments lack evidence, patients receive varying care based on the preferences of clinicians. Standard randomised controlled trials are unsuited to comparisons of different routine treatment strategies, and there remains little economic incentive for change.Integrating clinical trial infrastructure into electronic health record systems offers the potential for routine treatment comparisons at scale, through reduced trial costs. To date, embedded trials have automated data collection, participant identification and eligibility screening, but randomisation and consent remain manual and therefore costly tasks.This study will investigate the feasibility of using computer prompts to allow flexible randomisation at the point of clinical decision making. It will compare the effectiveness of two prompt designs through the lens of a candidate research question-comparing liberal or restrictive magnesium supplementation practices for critical care patients. It will also explore the acceptability of two consent models for conducting comparative effectiveness research. METHODS AND ANALYSIS: We will conduct a single centre, mixed-methods feasibility study, aiming to recruit 50 patients undergoing elective surgery requiring postoperative critical care admission. Participants will be randomised to either 'Nudge' or 'Preference' designs of electronic point-of-care randomisation prompt, and liberal or restrictive magnesium supplementation.We will judge feasibility through a combination of study outcomes. The primary outcome will be the proportion of prompts displayed resulting in successful randomisation events (compliance with the allocated magnesium strategy). Secondary outcomes will evaluate the acceptability of both prompt designs to clinicians and ascertain the acceptability of pre-emptive and opt-out consent models to patients. ETHICS AND DISSEMINATION: This study was approved by Riverside Research Ethics Committee (Ref: 21/LO/0785) and will be published on completion. TRIAL REGISTRATION NUMBER: NCT05149820

Warfare, Demography & Anthropogenic Transformation at Angel Mounds State Historic Site

poster abstractRecent investigations by the Department of Anthropology (IU School of Liberal Arts) and the Glenn A. Black Laboratory of Archaeology (IU-Bloomington) at Angel Mounds have greatly enhanced our understanding of this Mississippian period (AD 1050-1450) village located on the Ohio River in southwestern Indiana. During this timeframe, the Ohio Valley and adjoining regions witnessed an evolution in social complexity with the emergence of small-scale polities, population aggregation in fortified towns, and associated earthwork construction. Angel Mounds was established, grew in prominence, and was eventually abandoned. However, until recently, absolute ages from the site were sparse and the chronology of the town’s settlement, growth and abandonment was poorly understood. Similarly, chronological models for earthwork and fortification construction were non-existent. Our research has revealed that Angel Mounds began as a ceremonial center between AD 1100 and 1300 with few occupants. The residential population at Angel Mounds grew precipitously after AD 1300. By AD 1400, we estimate that as many as 1,000 people lived at Angel Mounds. Concurrently, a series of fortifications were erected at the site to protect the inhabitants from neighboring polities. Meanwhile, earthworks on site were “capped” and abandoned soon thereafter, which may reflect the sociopolitical disintegration of Angel Mounds. Depending on the type of agricultural production and environmental change with the onset of the Little Ice Age, these patterns have important implications for settlement longevities, the historical ecology of land-use, and population estimates in the Eastern Woodlands of North America by AD 1500. With support from the Nation Science Foundation, the next three years of investigations at Angel Mounds will continue to focus on population dynamics, earthwork construction and use, anthropogenic transformation of the landscape, and environmental change during the Medieval Warm and Little Ice Age

Right to Serve, Right to Lead: Lives and Legacies of the USCT

This is a catalog for an exhibit that follows the evolution of African-American participation in the Civil War, from slaves, to contrabands, to soldiers of the United States Colored Troops (USCT), as well as the lives of black veterans beyond the war, and their ultimate military and social legacy. Using a variety of period items, it creates a narrative that stretches from the Antebellum Period to the current day. In doing so, the exhibit shows how black sacrifice on the battlefield redefined the war\u27s purpose throughout the divided nation, how Jim Crowe suppressed the memory of black participation after Reconstruction, and how the illustrious African-American military tradition left by the USCT endures to this day in their modern heirs

Chronology of a Fortified Mississippian Village in the Central Illinois River Valley

Geophysical survey and excavations from 2010–2016 at Lawrenz Gun Club (11CS4), a late pre-Columbian village located in the central Illinois River valley in Illinois, identified 10 mounds, a central plaza, and dozens of structures enclosed within a stout 10 hectare bastioned palisade. Nineteen radiocarbon (14C) measurements were taken from single entities of wood charcoal, short-lived plants, and animal bones. A site chronology has been constructed using a Bayesian approach that considers the stratigraphic contexts and feature formation processes. The village was host to hundreds of years of continuous human activity during the Mississippi Period. Mississippian activity at the site is estimated to have begun in cal AD 990–1165 (95% probability), ended in cal AD 1295–1450 (95% probability), and lasted 150–420 yr (95% probability) in the primary Bayesian model with similar results obtained in two alternative models. The palisade is estimated to have been constructed in cal AD 1150–1230 (95% probability) and was continuously repaired and rebuilt for 15–125 yr (95% probability), probably for 40–85 yr (68% probability). Comparison to other studies demonstrates that the bastioned palisade at Lawrenz was one of the earliest constructed in the midcontinental United States

Impact of Digital Mammography on Cancer Detection and Recall Rates: 11.3 Million Screening Episodes in the English National Health Service Breast Cancer Screening Program.

Purpose To report the impact of changing from screen-film mammography to digital mammography (DM) in a large organized national screening program. Materials and Methods A retrospective analysis of prospectively collected annual screening data from 2009-2010 to 2015-2016 for the 80 facilities of the English National Health Service Breast Cancer Screening Program, together with estimates of DM usage for three time periods, enabled the effect of DM to be measured in a study of 11.3 million screening episodes in women aged 45-70 years (mean age, 59 years). Regression models were used to estimate percentage and absolute change in detection rates due to DM. Results The overall cancer detection rate was 14% greater with DM (P < .001). There were higher rates of detection of grade 1 and 2 invasive cancers (both ductal and lobular), but no change in the detection of grade 3 invasive cancers. The recall rate was almost unchanged by the introduction of DM. At prevalent (first) screening episodes for women aged 45-52 years, DM increased the overall detection rate by 19% (P < .001) and for incident screening episodes in women aged 53-70 years by 13% (P < .001). Conclusion The overall cancer detection rate was 14% greater with digital mammography with no change in recall rates and without confounding by changes in other factors. There was a substantially higher detection of grade 1 and grade 2 invasive cancers, including both ductal and lobular cancers, but no change in the detection of grade 3 invasive cancers. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by C.I. Lee and J.M. Lee in this issue