Change of Interest as a Function of Shift in Curricular Orientation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67119/2/10.1177_001316445301300213.pd

What can rotational splittings of low-luminosity subgiants actually tell us about the rotation profile?

Context. Inversions of the rotation profile using rotationally induced splittings of low-luminosity subgiant stars suggest that angular momentum transport mechanisms must be 1-2 orders of magnitude more efficient than theory predicts. The lack of precise high resolution of measurements of the rotation profile limits our understanding of the physical mechanism inducing excess angular momentum transport. Rotational inversions of low-luminosity subgiant stars are limited by current observations. Aims. We study the feasibility of making precise constraints to the rotation profile between the core and surface and the possibility of differentiating between rotation profile shapes using the observed rotational splittings of low-luminosity subgiant KIC 12508433. Methods. We use qualitative assumptions of extreme angular momentum transport mechanisms to prescribe the shape of the five synthetic profiles with the same core and surface rotation rates. We calculate the expected rotational splittings given these five profiles and analyse the differences between them. Markov chain Monte Carlo integration of the synthetic profiles using their associated splittings highlights the limited differentiability between rotation profiles that can currently be made. Results. Despite significant changes to the shape of the rotation profile, the rotational splittings deviate on a scale much smaller than the precision of splittings in current observations. We also find degeneracy between the surface rotation rate and position of strong differential rotation gradient of the inverted profiles. Conclusions. Constraining the physical mechanism contributing to more efficient angular momentum transport during the low-luminosity subgiant phase through the shape of the profile is impossible with current observations of $\ell$ = 1 and 2 rotationally split modes.Comment: 11 pages, 9 figures, 1 tabl

A randomized controlled trial to evaluate the role of interferon as initial and maintenance therapy in patients with follicular lymphoma

The purpose of this study was to evaluate the role of interferon as initial and maintenance therapy in patients with newly diagnosed follicular lymphoma. Between 1984 and 1994, 204 patients with newly diagnosed Stage III or Stage IV follicular lymphoma were randomized to receive either, Chlorambucil (CB): 10 mg daily for 6 weeks, followed by a 2-week interval, with 3 subsequent 2-week treatment periods at the same dose, separated by 2-week intervals, or, CB given concurrently with interferon (IFN). IFN was given at a dose of 3 × 106units thrice weekly, subcutaneously, throughout the 18-week treatment period. Responding patients were subsequently randomized to receive maintenance IFN at the dose and schedule described above, or to expectant management. The overall response rate was 161/204 (78%), complete remission being achieved in 24% of patients. Neither the addition of IFN to the initial treatment, nor the use of maintenance IFN influenced response rate, remission duration or survival. This study was undertaken to determine whether IFN, given in combination with, and then subsequent to, CB would alter the clinical course of patients with follicular lymphoma. Disappointingly, this objective was not achieved, no advantage having been demonstrated for the addition of IFN. © 2001 Cancer Research Campaign http://www.bjcancer.co

Pennsylvania Folklife Vol. 9, No. 4

• Dry Houses • Harvest Home • Golden Fields in the Golden Years • Illuminators, Scribes and Printers • John Drissel and His Boxes • Tick-Tock Time in Old Pennsylvania • About the Authors • Present Day Food Habits of the Pennsylvania Dutch • The Attitude of the Early Reformed Church Fathers Toward Worldly Amusementshttps://digitalcommons.ursinus.edu/pafolklifemag/1003/thumbnail.jp

Evolutionary connectionism: algorithmic principles underlying the evolution of biological organisation in evo-devo, evo-eco and evolutionary transitions

The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental organisations modifies the distribution of phenotypic variation, the evolution of ecological relationships modifies the selective environment, and the evolution of reproductive relationships modifies the heritability of the evolutionary unit. The major transitions in evolution, in particular, involve radical changes in developmental, ecological and reproductive organisations that instantiate variation, selection and inheritance at a higher level of biological organisation. However, current evolutionary theory is poorly equipped to describe how these organisations change over evolutionary time and especially how that results in adaptive complexes at successive scales of organisation (the key problem is that evolution is self-referential, i.e. the products of evolution change the parameters of the evolutionary process). Here we first reinterpret the central open questions in these domains from a perspective that emphasises the common underlying themes. We then synthesise the findings from a developing body of work that is building a new theoretical approach to these questions by converting well-understood theory and results from models of cognitive learning. Specifically, connectionist models of memory and learning demonstrate how simple incremental mechanisms, adjusting the relationships between individually-simple components, can produce organisations that exhibit complex system-level behaviours and improve the adaptive capabilities of the system. We use the term “evolutionary connectionism” to recognise that, by functionally equivalent processes, natural selection acting on the relationships within and between evolutionary entities can result in organisations that produce complex system-level behaviours in evolutionary systems and modify the adaptive capabilities of natural selection over time. We review the evidence supporting the functional equivalences between the domains of learning and of evolution, and discuss the potential for this to resolve conceptual problems in our understanding of the evolution of developmental, ecological and reproductive organisations and, in particular, the major evolutionary transitions

3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration

We acknowledge funding from the QMUL Pump-Priming Research Funding for Cross-Faculty Initiatives 2011-12 (EPSRC

Direct Presentation Is Sufficient for an Efficient Anti-Viral CD8+ T Cell Response

The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8+ T cell (TCD8+) responses to viruses is unclear mainly because of the difficulty in separating the two processes. Hence, while CP in the absence of DP has been clearly demonstrated, induction of an anti-viral TCD8+ response that excludes CP has never been purposely shown. Using vaccinia virus (VACV), which has been used as the vaccine to rid the world of smallpox and is proposed as a vector for many other vaccines, we show that DP is the main mechanism for the priming of an anti-viral TCD8+ response. These findings provide important insights to our understanding of how one of the most effective anti-viral vaccines induces immunity and should contribute to the development of novel vaccines

Differential Influence of Clonal Integration on Morphological and Growth Responses to Light in Two Invasive Herbs

Background and aims: In contrast to seeds, high sensitivity of vegetative fragments to unfavourable environments may limit the expansion of clonal invasive plants. However, clonal integration promotes the establishment of propagules in less suitable habitats and may facilitate the expansion of clonal invaders into intact native communities. Here, we examine the influence of clonal integration on the morphology and growth of ramets in two invasive plants, Alternanthera philoxeroides and Phyla canescens, under varying light conditions. Methods: In a greenhouse experiment, branches, connected ramets and severed ramets of the same mother plant were exposed under full sun and 85 % shade and their morphological and growth responses were assessed. Key results: The influence of clonal integration on the light reaction norm (connection6light interaction) of daughter ramets was species-specific. For A. philoxeroides, clonal integration evened out the light response (total biomass, leaf mass per area, and stem number, diameter and length) displayed in severed ramets, but these connection6light interactions were largely absent for P. canescens. Nevertheless, for both species, clonal integration overwhelmed light effect in promoting the growth of juvenile ramets during early development. Also, vertical growth, as an apparent shade acclimation response, was more prevalent in severed ramets than in connected ramets. Finally, unrooted branches displayed smaller organ size and slower growth than connected ramets, but the pattern of light reaction was similar, suggesting mothe