16,568 research outputs found

    Gravitational waves from the sound of a first order phase transition

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    We report on the first three-dimensional numerical simulations of first-order phase transitions in the early Universe to include the cosmic fluid as well as the scalar field order parameter. We calculate the gravitational wave (GW) spectrum resulting from the nucleation, expansion, and collision of bubbles of the low-temperature phase, for phase transition strengths and bubble wall velocities covering many cases of interest. We find that the compression waves in the fluid continue to be a source of GWs long after the bubbles have merged, a new effect not taken properly into account in previous modeling of the GW source. For a wide range of models, the main source of the GWs produced by a phase transition is, therefore, the sound the bubbles make

    Impacts of Alternative Policies Regulating Dockage

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    Agricultural and Food Policy, International Relations/Trade,

    Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema.

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    Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema. We show a single dose of a monoclonal antibody against beta1 integrin induced both functional and structural reversal of elastase-induced lung injury in vivo, and we found that similar matrix remodelling changes occurred in human lung tissue. We also identified a potential mechanism of action as this allosteric modulation of beta1 integrin inhibited elastase-induced caspase activation, F-actin aggregate formation and changes in cellular ATP levels. This was accompanied by maintenance of beta1?integrin levels and inhibition of caveolin-1 phosphorylation. We propose that allosteric modulation of beta1 integrin-mediated mechanosensing prevents cell death associated with lung injury and progressive emphysema, thus allowing cells to survive and for repair and regeneration to ensue

    Features and flaws of a contact interaction treatment of the kaon

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    Elastic and semileptonic transition form factors for the kaon and pion are calculated using the leading-order in a global-symmetry-preserving truncation of the Dyson-Schwinger equations and a momentum-independent form for the associated kernels in the gap and Bethe-Salpeter equations. The computed form factors are compared both with those obtained using the same truncation but an interaction that preserves the one-loop renormalisation-group behaviour of QCD and with data. The comparisons show that: in connection with observables revealed by probes with |Q^2|<~ M^2, where M~0.4GeV is an infrared value of the dressed-quark mass, results obtained using a symmetry-preserving regularisation of the contact-interaction are not realistically distinguishable from those produced by more sophisticated kernels; and available data on kaon form factors do not extend into the domain whereupon one could distinguish between the interactions. The situation is different if one includes the domain Q^2>M^2. Thereupon, a fully consistent treatment of the contact interaction produces form factors that are typically harder than those obtained with QCD renormalisation-group-improved kernels. Amongst other things also described are a Ward identity for the inhomogeneous scalar vertex, similarity between the charge distribution of a dressed-u-quark in the K^+ and that of the dressed-u-quark in the pi^+, and reflections upon the point whereat one might begin to see perturbative behaviour in the pion form factor. Interpolations of the form factors are provided, which should assist in working to chart the interaction between light-quarks by explicating the impact on hadron properties of differing assumptions about the behaviour of the Bethe-Salpeter kernel.Comment: 17 pages, 9 figures, 4 table

    Flavor SU(4) breaking between effective couplings

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    Using a framework in which all elements are constrained by Dyson-Schwinger equation studies in QCD, and therefore incorporates a consistent, direct and simultaneous description of light- and heavy-quarks and the states they constitute, we analyze the accuracy of SU(4)-flavor symmetry relations between {\pi}{\rho}{\pi}, K{\rho}K and D{\rho}D couplings. Such relations are widely used in phenomenological analyses of the interactions between matter and charmed mesons. We find that whilst SU(3)-flavor symmetry is accurate to 20%, SU(4) relations underestimate the D{\rho}D coupling by a factor of five.Comment: 5 pages, two figure

    Cell biology:Collagen secretion explained

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    Cells package proteins into vesicles for secretion to the extracellular milieu. A study shows that an enzyme modifies the packaging machinery to encapsulate unusually large proteins such as collagen

    What can a mean-field model tell us about the dynamics of the cortex?

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    In this chapter we examine the dynamical behavior of a spatially homogeneous two-dimensional model of the cortex that incorporates membrane potential, synaptic flux rates and long- and short-range synaptic input, in two spatial dimensions, using parameter sets broadly realistic of humans and rats. When synaptic dynamics are included, the steady states may not be stable. The bifurcation structure for the spatially symmetric case is explored, identifying the positions of saddle–node and sub- and supercritical Hopf instabilities. We go beyond consideration of small-amplitude perturbations to look at nonlinear dynamics. Spatially-symmetric (breathing mode) limit cycles are described, as well as the response to spatially-localized impulses. When close to Hopf and saddle–node bifurcations, such impulses can cause traveling waves with similarities to the slow oscillation of slow-wave sleep. Spiral waves can also be induced. We compare model dynamics with the known behavior of the cortex during natural and anesthetic-induced sleep, commenting on the physiological significance of the limit cycles and impulse responses
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