The consumption of young adults during economic depression A comparative study of Britain and Finland, 1990-1994 1990-1994

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BAP1 Germline Mutations in Finnish Patients with Uveal Melanoma

Purpose: Germline mutations of the BRCA1-associated protein-1 gene (BAP1) predispose carriers to uveal melanoma. We report the population-based frequency of germline pathogenic variants of BAP1 in Finnish patients with uveal melanoma who live in a high-risk region for this cancer. Design: Cohort study. Participants: In Finland, uveal melanomas are treated centrally in the Ocular Oncology Service, Helsinki University Hospital. We collected clinical data and genomic DNA from 148 of 188 consecutive patients diagnosed from January 2010 through December 2012. Seven of these patients from 6 families had a history of uveal melanoma in 1 relative, and 2 patients from 2 additional families had such a history in 2 relatives. Methods: Sequencing BAP1. Main Outcome Measures: Pathogenic variants in BAP1. Results: We found 2 different pathogenic variants in BAP1 in 3 patients. Two patients had a single nucleotide insertion in exon 14 resulting in a shift of reading frame. Both had a family history of uveal melanoma in at least 1 relative. One patient without a family history of uveal melanoma had a single nucleotide substitution in the conserved splice donor site of intron 2. BAP1 cancer predisposition syndrome-related cancers were present in all 3 families. The overall frequency of BAP1 pathogenic variants was 2.0% (3/148; 95% confidence interval, 0.4-5.8), the frequency among patients 50 years of age or younger was 3.6% (1/28; 95% confidence interval, 0.1-18), and a pathogenic variant was detected in 2 of 8 families with a history of uveal melanoma. Conclusions: The frequency of BAP1 germline pathogenic variants in consecutive Finnish patients with uveal melanoma who come from a high-risk region for the development of this cancer is comparable with reports from other populations. (C) 2016 by the American Academy of Ophthalmology.Peer reviewe

Who has a wine-identity? Consumption practices between distinction and democratization

The relevance of consumer goods and consumer behaviour for the constitution and confirmation of a self-concept is widely acknowledged in consumer studies. However, in light of discussions in sociological theory, there is a question whether this is a selfconcept planed individually and connected to feelings of anxiety, as analysts of the contemporary society like Baumann, Beck and Giddens would have it, or whether consumption in the end is still bound to social identities grounded in belonging to social categories or socio-economic position. The question is empirically tested in this essay using the example of wine consumption and the relevance of such consumption for constructing a self-concept. The empirical analysis indicates first, that only a small group of consumers with high involvement in wine consumption considers wine relevant for their identity, and second, that both the construction of a wine-related consumer identity, as well as the feelings of insecurity and embarrassment associated with it are not directly influenced by socio-structural factors. Instead, in the case of wine consumption, these are transmitted through lifestyles and social networks