Improvement of Thymopoiesis after Hematopoietic Stem Cell Transplantation by Cytokines: Translational studies in experimental animal models

Allogeneic hematopoietic stem cell transplantation (AlloHSCT) is a powerful treatment modality that is frequently applied as part of treatment of hematological malignancies, aplastic anemia and inborn errors of hematopoietic progenitor cells. A major drawback of alloHSCT is the treatment related morbidity and treatment related mortality (TRM), which are largely accounted for by opportunistic infections. Those infections occur during a prolonged period (1-2 years), characterized by an impaired reconstitution of the adaptive immune system. Especially, the recovery of naïve T cells and thymopoiesis are protracted after transplantation, but are considered pivotal for restoration of anti-infectious immunity. This thesis has experimentally addressed new strategies that may improve thymopoiesis, including the post-transplant administration of cytokines that are physiologically involved in the differentiation and proliferation of thymocytes

All conformally flat pure radiation metrics

The complete class of conformally flat, pure radiation metrics is given, generalising the metric recently given by Wils.Comment: 7 pages, plain Te

Scientific Expertise in Child Protection Policies and Juvenile Justice Practices in Twentieth-Century Belgium

Modern society cannot function without experts and yet we increasingly question the authority of those who advise us. The essays in this collection explore our reliance on experts within a historical context and across a wide range of fields, including agriculture, engineering, health sciences and labour management. Contributors argue that experts were highly aware of their audiences and used performance to gain both scientific and popular support

Discovery of a Very Young Field L Dwarf, 2MASS J01415823-4633574

While following up L dwarf candidates selected photometrically from the Two Micron All Sky Survey, we uncovered an unusual object designated 2MASS J01415823-4633574. Its optical spectrum exhibits very strong bands of vanadium oxide but abnormally weak absorptions by titanium oxide, potassium, and sodium. Morphologically such spectroscopic characteristics fall intermediate between old, field early-L dwarfs (log(g)~5) and very late M giants (log(g)~0), leading us to favor low gravity as the explanation for the unique spectral signatures of this L dwarf. Such a low gravity can be explained only if this L dwarf is much lower in mass than a typical old field L dwarf of similar temperature and is still contracting to its final radius. These conditions imply a very young age. Further evidence of youth is found in the near-infrared spectrum, including a triangular-shaped H-band continuum reminiscent of young brown dwarf candidates discovered in the Orion Nebula Cluster. Using the above information along with comparisons to brown dwarf atmospheric and interior models, our current best estimate is that this L dwarf has an age of 1-50 Myr and a mass of 6-25 M_Jupiter. The location of 2MASS 0141-4633 on the sky coupled with a distance estimate of ~35 pc and the above age estimate suggests that this object may be a brown dwarf member of either the 30-Myr-old Tucana/Horologium Association or the ~12-Myr-old beta Pic Moving Group.Comment: Accepted for publication in the 10 March 2006 issue (volume 639) of the Astrophysical Journa

Interpreting a conformally flat pure radiation space-time

A physical interpretation is presented of the general class of conformally flat pure radiation metrics that has recently been identified by Edgar and Ludwig. It is shown that, at least in the weak field limit, successive wave surfaces can be represented as null (half) hyperplanes rolled around a two-dimensional null cone. In the impulsive limit, the solution reduces to a pp-wave whose direction of propagation depends on retarded time. In the general case, there is a coordinate singularity which corresponds to an envelope of the wave surfaces. The global structure is discussed and a possible vacuum extension through the envelope is proposed.Comment: 9 pages, Plain TeX, 2 figures. To appear in Class. Quantum Grav. Reference adde

Cataclysmic Variables from the Catalina Real-time Transient Survey

We present 855 cataclysmic variable candidates detected by the Catalina Real-time Transient Survey (CRTS) of which at least 137 have been spectroscopically confirmed and 705 are new discoveries. The sources were identified from the analysis of five years of data, and come from an area covering three quarters of the sky. We study the amplitude distribution of the dwarf novae CVs discovered by CRTS during outburst, and find that in quiescence they are typically two magnitudes fainter compared to the spectroscopic CV sample identified by SDSS. However, almost all CRTS CVs in the SDSS footprint have ugriz photometry. We analyse the spatial distribution of the CVs and find evidence that many of the systems lie at scale heights beyond those expected for a Galactic thin disc population. We compare the outburst rates of newly discovered CRTS CVs with the previously known CV population, and find no evidence for a difference between them. However, we find that significant evidence for a systematic difference in orbital period distribution. We discuss the CVs found below the orbital period minimum and argue that many more are yet to be identified among the full CRTS CV sample. We cross-match the CVs with archival X-ray catalogs and find that most of the systems are dwarf novae rather than magnetic CVs.Comment: 15 pages, 17 figures, accepted MNRA

On the Symmetries of the Edgar-Ludwig Metric

The conformal Killing equations for the most general (non-plane wave) conformally flat pure radiation field are solved to find the conformal Killing vectors. As expected fifteen independent conformal Killing vectors exist, but in general the metric admits no Killing or homothetic vectors. However for certain special cases a one-dimensional group of homotheties or motions may exist and in one very special case, overlooked by previous investigators, a two-dimensional homethety group exists. No higher dimensional groups of motions or homotheties are admitted by these metrics.Comment: Plain TeX, 7 pages, No figure

The Orbital Period and Negative Superhumps of the Nova-Like Cataclysmic Variable V378 Pegasi

A radial velocity study is presented of the cataclysmic variable V378 Pegasi (PG 2337+300). It is found to have an orbital period of 0.13858 +/- 0.00004 d (3.32592 +/- 0.00096 hours). Its spectrum and long-term light curve suggest that V378 Peg is a nova-like variable, with no outbursts. We use the approximate distance and position in the Galaxy of V378 Peg to estimate E(B-V) = 0.095, and use near-infrared magnitudes to calculate a distance of 680 +/- 90 pc and M_V = 4.68 +/- 0.70, consistent with V378 Peg being a nova-like. Time-resolved photometry taken between 2001 and 2009 reveals a period of 0.1346 +/- 0.0004 d (3.23 +/- 0.01 hours). We identify this photometric variability to be negative superhumps, from a precessing, tilted accretion disk. Our repeated measurements of the photometric period of V378 Peg are consistent with this period having been stable between 2001 and 2009, with its negative superhumps showing coherence over as many as hundreds or even thousands of cycles.Comment: 24 pages, 19 figures, accepted for publication in New Astronom

Explicit Kundt type II and N solutions as gravitational waves in various type D and O universes

A particular yet large class of non-diverging solutions which admits a cosmological constant, electromagnetic field, pure radiation and/or general non-null matter component is explicitly presented. These spacetimes represent exact gravitational waves of arbitrary profiles which propagate in background universes such as Minkowski, conformally flat (anti-)de Sitter, Edgar-Ludwig, Bertotti-Robinson, and type D (anti-)Nariai or Plebanski-Hacyan spaces, and their generalizations. All possibilities are discussed and are interpreted using a unifying simple metric form. Sandwich and impulsive waves propagating in the above background spaces with different geometries and matter content can easily be constructed. New solutions are identified, e.g. type D pure radiation or explicit type II electrovacuum waves in (anti-)Nariai universe. It is also shown that, in general, there are no conformally flat Einstein-Maxwell fields with a non-vanishing cosmological constant.Comment: 17 pages, LaTeX 2e. v2: added two references concerning generalized Kerr-Schild transformations, minor changes in the tex