Allogeneic hematopoietic stem cell transplantation (AlloHSCT) is a powerful treatment
modality that is frequently applied as part of treatment of hematological malignancies,
aplastic anemia and inborn errors of hematopoietic progenitor cells. A major drawback of
alloHSCT is the treatment related morbidity and treatment related mortality (TRM), which
are largely accounted for by opportunistic infections. Those infections occur during a
prolonged period (1-2 years), characterized by an impaired reconstitution of the adaptive
immune system. Especially, the recovery of naïve T cells and thymopoiesis are protracted
after transplantation, but are considered pivotal for restoration of anti-infectious immunity.
This thesis has experimentally addressed new strategies that may improve thymopoiesis,
including the post-transplant administration of cytokines that are physiologically involved in
the differentiation and proliferation of thymocytes
