Experiments for electromagnetic levitation in microgravity

Containerless processing is a promising research tool for investigating the properties of undercooled melts and their solidification. For conducting samples RF-electromagnetic levitation offers the possibility to obtain large undercoolings by avoiding heterogeneous nucleation at container walls. On earth, however, strong magnetic fields are needed to compensate the gravitational force which imposes a lower limit on the available temperatures and on the accessible undercooling range. Under microgravity conditions the magnetic positioning fields can be minimized and hence, undercooling becomes feasible under ultra-high vacuum conditions and lower temperatures become accessible. In contrast to other undercooling and solidification techniques, electromagnetic levitation allows for diagnostic measurements during the early steps of nucleation and phase selection. Experiments cover a wide field of research topics: nucleation, directional solidification at high velocities, generation of metastable phases, evolution of microstructures, properties of undercooled liquids. Examples from these classes including experiments selected for the IML-2 mission are discussed with emphasis on technical requirements. An overview is given on the German TEMPUS (electromagnetic levitation facility) program

TEMPUS: First results

The electromagnetic levitation facility, TEMPUS, developed by Dornier is designed to operate under microgravity conditions. Compared to terrestrial levitation, microgravity offers the possibility to melt and undercool in ultra high vacuum, thereby, providing an ultra clean environment. The technical concept of the TEMPUS facility was tested on two KC 135 flights and in the Texus 22 mission. Preparative investigations concerning the coil system and the heating and positioning efficiencies were carried out in the TEMPUS laboratory version. Furthermore, temperature-time profiles were determined under various boundary conditions. As a consequence of processing liquid metals under UHV, correct temperature measurement arises as the most critical problem. Experiences with experiments in the TEMPUS laboratory module show that due to the evaporation losses of the sample, the transmission of the CaF2 shielding windows changes drastically during the processing time. The investigation of the effect of contamination on pyrometry and the development of alternative evaporation shielding methods were initiated. During the second KC 135 flight, it was possible to heat up and melt an FeNi sample under He atmosphere. Oscillations of the molten sample, which were excited by switching out the magnetic heating field, could be detected and afterwards analyzed. From the frequency of these oscillations the surface tension of the sample material could be derived. The measurement of the surface tension and viscosity of an undercooled metal is proposed for TEMPUS on IML-2. This document is presented in view graph form

"A Decentralized Operations Concept for the European Payloads on the International Space Station"

The European Module Columbus of the International Space Station (ISS) is planned to be launched 2004. For its exploitation phase as well as for the early utilisation of the Space Station starting from 2003 onwards the operations procedures are now being defined in detail and the implementation of specific infrastructure has started. A decentralised operations concept will allow the investigators to perform their experiments using the telescience technique of remote experiment operations whenever feasible. User Support and Operation Centres (USOCs) will act as Facility Responsible Centres (FRC) performing the operations for multi user experiment facilities. The Columbus Control Centre (COL-CC) will perform the Columbus system operations, co-ordinate the European payload operations and provide the European Communications network. This paper gives an overview on the operations concepts and the tasks and set up of the involved sites

Nucleation and Bulk Crystallization in Binary Phase Field Theory

We present a phase field theory for binary crystal nucleation. In the one-component limit, quantitative agreement is achieved with computer simulations (Lennard-Jones system) and experiments (ice-water system) using model parameters evaluated from the free energy and thickness of the interface. The critical undercoolings predicted for Cu-Ni alloys accord with the measurements, and indicate homogeneous nucleation. The Kolmogorov exponents deduced for dendritic solidification and for "soft-impingement" of particles via diffusion fields are consistent with experiment.Comment: 4 pages, 4 figures, accepted to PR

NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle

p63 is a sequence-specific transcription factor that regulates epithelial stem cell maintenance and epithelial differentiation. In addition, the TAp63 isoform with an N-terminal transactivation domain functions as an inducer of apoptosis during the development of sympathetic neurons. Previous work has indicated that the co-activator and histone acetyltransferase (HAT), p300, can bind to TAp63 and stimulate TAp63-dependent transcription of the p21Cip1 gene. Novel INHAT Repressor (NIR) is an inhibitor of HAT. Here, we report that the central portion of NIR binds to the transactivation domain and the C-terminal oligomerization domain of TAp63. NIR is highly expressed in G2/M phase of the cell cycle and only weakly expressed in G1/S. Furthermore, except during mitosis, NIR is predominantly localized in the nucleolus; only a small portion co-localizes with TAp63 in the nucleoplasm and at the p21 gene promoter. Consistent with NIR acting as a repressor, the induced translocation of NIR from the nucleolus into the nucleoplasm resulted in the inhibition of TAp63-dependent transactivation of p21. Conversely, knockdown of NIR by RNAi stimulated p21 transcription in the presence of TAp63. Thus, NIR is a cell-cycle-controlled, novel negative regulator of TAp63. The low levels of nucleoplasmic NIR might act as a buffer toward potentially toxic TAp63