180 research outputs found
Diagnostic Validity of Patient-Reported History for Shoulder Pathology
Objective The purpose of this article is to determine whether patient-reported history items are predictive of shoulder pathology and have the potential for use in triaging patients with shoulder pathology to orthopaedic outpatient clinics. Setting It is set at two tertiary orthopaedic clinics. Patients All new patients reporting pain and/or disability of the shoulder joint were prospectively recruited. A total of 193 patients were enrolled, 15 of whom withdrew, leaving 178 patients composing the study sample. Design Patients completed a questionnaire on the history of their pathology, then the surgeon took a thorough history indicating the most likely diagnosis. The clinician then performed appropriate physical examination. Arthroscopy was the reference standard for those undergoing surgery and magnetic resonance imaging (MRI) with arthrogram for all others. We calculated the sensitivity, specificity, and likelihood ratios (LRs) of history items alone and in combination. We used the LRs to generate a clinical decision algorithm. Main Outcome Measures Diagnosis was determined through arthroscopy or MRI arthrogram. Reporting was standardized to ensure review of all structures. Results The physical examination and history agreed in 75% of cases. Of those that did not agree, the physical examination misdirected the diagnosis in 47% of our cases. In particular, history items were strong predictors of anterior and posterior instability and subscapularis tears and were combined in a tool to be utilized for screening patients. Conclusion The patient-reported history items were effective for diagnosing shoulder pathology and should be considered for use in a triaging instrument
Molecular dynamics simulations of vibrated granular gases
We present molecular dynamics simulations of mono- or bidisperse inelastic
granular gases driven by vibrating walls, in two dimensions (without gravity).
Because of the energy injection at the boundaries, a situation often met
experimentally, density and temperature fields display heterogeneous profiles
in the direction perpendicular to the walls. A general equation of state for an
arbitrary mixture of fluidized inelastic hard spheres is derived and
successfully tested against numerical data. Single-particle velocity
distribution functions with non-Gaussian features are also obtained, and the
influence of various parameters (inelasticity coefficients, density...)
analyzed. The validity of a recently proposed Random Restitution Coefficient
model is assessed through the study of projected collisions onto the direction
perpendicular to that of energy injection. For the binary mixture, the
non-equipartition of translational kinetic energy is studied and compared both
to experimental data and to the case of homogeneous energy injection
(``stochastic thermostat''). The rescaled velocity distribution functions are
found to be very similar for both species
Tracer diffusion in granular shear flows
Tracer diffusion in a granular gas in simple shear flow is analyzed. The
analysis is made from a perturbation solution of the Boltzmann kinetic equation
through first order in the gradient of the mole fraction of tracer particles.
The reference state (zeroth-order approximation) corresponds to a Sonine
solution of the Boltzmann equation, which holds for arbitrary values of the
restitution coefficients. Due to the anisotropy induced in the system by the
shear flow, the mass flux defines a diffusion tensor instead of a
scalar diffusion coefficient. The elements of this tensor are given in terms of
the restitution coefficients and mass and size ratios. The dependence of the
diffusion tensor on the parameters of the problem is illustrated in the
three-dimensional case. The results show that the influence of dissipation on
the elements is in general quite important, even for moderate values
of the restitution coefficients. In the case of self-diffusion (mechanically
equivalent particles), the trends observed in recent molecular dynamics
simulations are similar to those obtained here from the Boltzmann kinetic
theory.Comment: 5 figure
Diffusion of impurities in a granular gas
Diffusion of impurities in a granular gas undergoing homogeneous cooling
state is studied. The results are obtained by solving the Boltzmann--Lorentz
equation by means of the Chapman--Enskog method. In the first order in the
density gradient of impurities, the diffusion coefficient is determined as
the solution of a linear integral equation which is approximately solved by
making an expansion in Sonine polynomials. In this paper, we evaluate up to
the second order in the Sonine expansion and get explicit expressions for
in terms of the restitution coefficients for the impurity--gas and gas--gas
collisions as well as the ratios of mass and particle sizes. To check the
reliability of the Sonine polynomial solution, analytical results are compared
with those obtained from numerical solutions of the Boltzmann equation by means
of the direct simulation Monte Carlo (DSMC) method. In the simulations, the
diffusion coefficient is measured via the mean square displacement of
impurities. The comparison between theory and simulation shows in general an
excellent agreement, except for the cases in which the gas particles are much
heavier and/or much larger than impurities. In theses cases, the second Sonine
approximation to improves significantly the qualitative predictions made
from the first Sonine approximation. A discussion on the convergence of the
Sonine polynomial expansion is also carried out.Comment: 9 figures. to appear in Phys. Rev.
Navier-Stokes transport coefficients of -dimensional granular binary mixtures at low density
The Navier-Stokes transport coefficients for binary mixtures of smooth
inelastic hard disks or spheres under gravity are determined from the Boltzmann
kinetic theory by application of the Chapman-Enskog method for states near the
local homogeneous cooling state. It is shown that the Navier-Stokes transport
coefficients are not affected by the presence of gravity. As in the elastic
case, the transport coefficients of the mixture verify a set of coupled linear
integral equations that are approximately solved by using the leading terms in
a Sonine polynomial expansion. The results reported here extend previous
calculations [V. Garz\'o and J. W. Dufty, Phys. Fluids {\bf 14}, 1476 (2002)]
to an arbitrary number of dimensions. To check the accuracy of the
Chapman-Enskog results, the inelastic Boltzmann equation is also numerically
solved by means of the direct simulation Monte Carlo method to evaluate the
diffusion and shear viscosity coefficients for hard disks. The comparison shows
a good agreement over a wide range of values of the coefficients of restitution
and the parameters of the mixture (masses and sizes).Comment: 6 figures, to be published in J. Stat. Phy
Mechanisms of Size Control and Polymorphism in Viral Capsid Assembly
We simulate the assembly dynamics of icosahedral capsids from subunits that
interconvert between different conformations (or quasi-equivalent states). The
simulations identify mechanisms by which subunits form empty capsids with only
one morphology but adaptively assemble into different icosahedral morphologies
around nanoparticle cargoes with varying sizes, as seen in recent experiments
with brome mosaic virus (BMV) capsid proteins. Adaptive cargo encapsidation
requires moderate cargo-subunit interaction strengths; stronger interactions
frustrate assembly by stabilizing intermediates with incommensurate curvature.
We compare simulation results to experiments with cowpea chlorotic mottle virus
empty capsids and BMV capsids assembled on functionalized nanoparticles and
suggest new cargo encapsidation experiments. Finally, we find that both empty
and templated capsids maintain the precise spatial ordering of subunit
conformations seen in the crystal structure even if interactions that preserve
this arrangement are favored by as little as the thermal energy, consistent
with experimental observations that different subunit conformations are highly
similar
Invaders in hot water: a simple decontamination method to prevent the accidental spread of aquatic invasive non-native species.
Watersports equipment can act as a vector for the introduction and spread of invasive non native species (INNS) in freshwater environments. To support advice given to recreational water users under the UK Governmentâs Check Clean Dry biosecurity campaign and ensure its effectiveness at killing a range of aquatic INNS, we conducted a survival experiment on seven INNS which pose a high risk to UK freshwaters. The efficacy of exposure to hot water (45 °C, 15 min) was tested as a method by which waters users could âcleanâ their equipment and was compared to drying and a control group (no treatment). Hot water had caused 99 % mortality across all species 1 h after treatment and was more effective than drying at all time points (1 h: Ï2 = 117.24, p < 0.001; 1 day Ï2 = 95.68, p < 0.001; 8 days Ï2 = 12.16, p < 0.001 and 16 days Ï2 = 7.58, p < 0.001). Drying caused significantly higher mortality than the control (no action) from day 4 (Ï2 = 8.49, p < 0.01) onwards. In the absence of hot water or drying, 6/7 of these species survived for 16 days, highlighting the importance of good biosecurity practice to reduce the risk of accidental spread. In an additional experiment the minimum lethal temperature and exposure time in hot water to cause 100 % mortality in American signal crayfish (Pacifastacus leniusculus), was determined to be 5 min at 40 °C. Hot water provides a simple, rapid and effective method to clean equipment. We recommend that it is advocated in future biosecurity awareness campaigns
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