6,223 research outputs found
Associations between Sleep Problems and Anxiety in Youth
Most of us are able to recall sleepless nights during periods of heightened anxiety, and the associations between sleep and anxiety are sufficiently well established to be acknowledged in the DSM-IV (American Psychiatric Association, 1994). Indeed, sleeprelated difficulties are included in the diagnostic criteria for posttraumatic stress disorder, acute stress disorder and generalized anxiety disorder. In contrast to the wealth of literature highlighting associations between sleep problems and anxiety in adults, less is known about these associations in children and adolescents.
It is important to understand associations between disorders as there is evidence to suggest that co-occurring difficulties may result in greater impairment than those occurring alone. For example, a study focusing upon depression found that individuals with co-occurring disorders were more likely to demonstrate suicidal behaviour as compared to those with pure depression (Rohde et al., 1991). Furthermore, focusing upon children is important as various difficulties, including anxiety, may appear early in life and persist into adulthood (Kim- Cohen et al., 2003). This article summarises some key findings with regards to the associations between sleep problems and anxiety in youth and proposes possible clinical implications of this research
Anxiety disorders and sleep in children and adolescents
Sleep problems are common in children and adolescents. A growing body of research has explored the relationship between sleep problems and anxiety in youth. When reviewing the literature, methodologic inconsistencies need to be considered, such as variation in conceptualization of sleep problems, measurement of sleep, and the classification of anxiety. Despite this, there seems to be good evidence of concurrent and longitudinal associations between sleep difficulties and anxiety in community and clinical samples of young people. Potential mechanisms are proposed. There is a need for further exploration of these relationships, with the hope of aiding preventive capability and developing useful treatments
eIF4A Inhibition Allows Translational Regulation of mRNAs Encoding Proteins Involved in Alzheimer's Disease
Alzheimer's disease (AD) is the main cause of dementia in our increasingly aging population. The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing illness for patients and carers. Although drugs have been developed to treat AD symptoms and to slow disease progression, there is currently no cure. The incidence of AD is predicted to increase to over one hundred million by 2050, placing a heavy burden on communities and economies, and making the development of effective therapies an urgent priority. Two proteins are thought to have major contributory roles in AD: the microtubule associated protein tau, also known as MAPT; and the amyloid-beta peptide (A-beta), a cleavage product of amyloid precursor protein (APP). Oxidative stress is also implicated in AD pathology from an early stage. By targeting eIF4A, an RNA helicase involved in translation initiation, the synthesis of APP and tau, but not neuroprotective proteins, can be simultaneously and specifically reduced, representing a novel avenue for AD intervention. We also show that protection from oxidative stress is increased upon eIF4A inhibition. We demonstrate that the reduction of these proteins is not due to changes in mRNA levels or increased protein degradation, but is a consequence of translational repression conferred by inhibition of the helicase activity of eIF4A. Inhibition of eIF4A selectively and simultaneously modulates the synthesis of proteins involved in Alzheimer's disease: reducing A-beta and tau synthesis, while increasing proteins predicted to be neuroprotective
Tree migration-rates : narrowing the gap between inferred post-glacial rates and projected rates
Faster-than-expected post-glacial migration rates of trees have puzzled ecologists for a long time. In Europe, post-glacial migration is assumed to have started from the three southern European peninsulas (southern refugia), where large areas remained free of permafrost and ice at the peak of the last glaciation. However, increasing palaeobotanical evidence for the presence of isolated tree populations in more northerly microrefugia has started to change this perception. Here we use the Northern Eurasian Plant Macrofossil Database and palaeoecological literature to show that post-glacial migration rates for trees may have been substantially lower (60β260 m yrβ1) than those estimated by assuming migration from southern refugia only (115β550 m yrβ1), and that early-successional trees migrated faster than mid- and late-successional trees. Post-glacial migration rates are in good agreement with those recently projected for the future with a population dynamical forest succession and dispersal model, mainly for early-successional trees and under optimal conditions. Although migration estimates presented here may be conservative because of our assumption of uniform dispersal, tree migration-rates clearly need reconsideration. We suggest that small outlier populations may be a key factor in understanding past migration rates and in predicting potential future range-shifts. The importance of outlier populations in the past may have an analogy in the future, as many tree species have been planted beyond their natural ranges, with a more beneficial microclimate than their regional surroundings. Therefore, climate-change-induced range-shifts in the future might well be influenced by such microrefugia
The Nuclear Pore Complex Mediates Binding of the Mig1 Repressor to Target Promoters
All eukaryotic cells alter their transcriptional program in response to the sugar glucose. In Saccharomyces cerevisiae, the best-studied downstream effector of this response is the glucose-regulated repressor Mig1. We show here that nuclear pore complexes also contribute to glucose-regulated gene expression. NPCs participate in glucose-responsive repression by physically interacting with Mig1 and mediating its function independently of nucleocytoplasmic transport. Surprisingly, despite its abundant presence in the nucleus of glucose-grown nup120Ξ or nup133Ξ cells, Mig1 has lost its ability to interact with target promoters. The glucose repression defect in the absence of these nuclear pore components therefore appears to result from the failure of Mig1 to access its consensus recognition sites in genomic DNA. We propose that the NPC contributes to both repression and activation at the level of transcription
Continuity properties of measurable group cohomology
A version of group cohomology for locally compact groups and Polish modules
has previously been developed using a bar resolution restricted to measurable
cochains. That theory was shown to enjoy analogs of most of the standard
algebraic properties of group cohomology, but various analytic features of
those cohomology groups were only partially understood.
This paper re-examines some of those issues. At its heart is a simple
dimension-shifting argument which enables one to `regularize' measurable
cocycles, leading to some simplifications in the description of the cohomology
groups. A range of consequences are then derived from this argument.
First, we prove that for target modules that are Fr\'echet spaces, the
cohomology groups agree with those defined using continuous cocycles, and hence
they vanish in positive degrees when the acting group is compact. Using this,
we then show that for Fr\'echet, discrete or toral modules the cohomology
groups are continuous under forming inverse limits of compact base groups, and
also under forming direct limits of discrete target modules.
Lastly, these results together enable us to establish various circumstances
under which the measurable-cochains cohomology groups coincide with others
defined using sheaves on a semi-simplicial space associated to the underlying
group, or sheaves on a classifying space for that group. We also prove in some
cases that the natural quotient topologies on the measurable-cochains
cohomology groups are Hausdorff.Comment: 52 pages. [Nov 22, 2011:] Major re-write with Calvin C. Moore as new
co-author. Results from previous version strengthened and several new results
added. [Nov 25, 2012:] Final version now available at springerlink.co
Climate vulnerability assessment for Pacific salmon and steelhead in the California Current Large Marine Ecosystem.
Major ecological realignments are already occurring in response to climate change. To be successful, conservation strategies now need to account for geographical patterns in traits sensitive to climate change, as well as climate threats to species-level diversity. As part of an effort to provide such information, we conducted a climate vulnerability assessment that included all anadromous Pacific salmon and steelhead (Oncorhynchus spp.) population units listed under the U.S. Endangered Species Act. Using an expert-based scoring system, we ranked 20 attributes for the 28 listed units and 5 additional units. Attributes captured biological sensitivity, or the strength of linkages between each listing unit and the present climate; climate exposure, or the magnitude of projected change in local environmental conditions; and adaptive capacity, or the ability to modify phenotypes to cope with new climatic conditions. Each listing unit was then assigned one of four vulnerability categories. Units ranked most vulnerable overall were Chinook (O. tshawytscha) in the California Central Valley, coho (O. kisutch) in California and southern Oregon, sockeye (O. nerka) in the Snake River Basin, and spring-run Chinook in the interior Columbia and Willamette River Basins. We identified units with similar vulnerability profiles using a hierarchical cluster analysis. Life history characteristics, especially freshwater and estuary residence times, interplayed with gradations in exposure from south to north and from coastal to interior regions to generate landscape-level patterns within each species. Nearly all listing units faced high exposures to projected increases in stream temperature, sea surface temperature, and ocean acidification, but other aspects of exposure peaked in particular regions. Anthropogenic factors, especially migration barriers, habitat degradation, and hatchery influence, have reduced the adaptive capacity of most steelhead and salmon populations. Enhancing adaptive capacity is essential to mitigate for the increasing threat of climate change. Collectively, these results provide a framework to support recovery planning that considers climate impacts on the majority of West Coast anadromous salmonids
The PyCBC search for gravitational waves from compact binary coalescence
We describe the PyCBC search for gravitational waves from compact-object
binary coalescences in advanced gravitational-wave detector data. The search
was used in the first Advanced LIGO observing run and unambiguously identified
two black hole binary mergers, GW150914 and GW151226. At its core, the PyCBC
search performs a matched-filter search for binary merger signals using a bank
of gravitational-wave template waveforms. We provide a complete description of
the search pipeline including the steps used to mitigate the effects of noise
transients in the data, identify candidate events and measure their statistical
significance. The analysis is able to measure false-alarm rates as low as one
per million years, required for confident detection of signals. Using data from
initial LIGO's sixth science run, we show that the new analysis reduces the
background noise in the search, giving a 30% increase in sensitive volume for
binary neutron star systems over previous searches.Comment: 29 pages, 7 figures, accepted by Classical and Quantum Gravit
Influence of lived experience on risk perception among women who received a breast cancer polygenic risk score: 'Another piece of the pie'
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