A chemoenzymatic route to the (+)-form of the amaryllidaceae alkaloid narseronine

The enzymatically derived and enantiopure cis-1,2-dihydrocatechol 1 has been converted, over 14 one-pot operations, into the (+)-form of the alkaloid narseronine (2). The present study, which complements earlier work that established a route from metabolite 1 to enantiomer (–)-2, involves an N-bromosuccinimide/tri-n-butyltin hydride-mediated cyclisation reaction to construct the unsaturated B-ring lactone of the target compound.We thank the Australian Research Council and the Institute of Advanced Studies for generous financial support

Effects of aircraft noise on flight and ground structures

Acoustic loads measured on jet-powered STOL configurations are presented for externally blown and upper surface blown flap models ranging in size from a small laboratory model up to a full-scale aircraft model. The implications of the measured loads for potential acoustic fatigue and cabin noise are discussed. Noise transmission characteristics of light aircraft structures are presented. The relative importance of noise transmission paths, such as fuselage sidewall and primary structure, is estimated. Acceleration responses of a historic building and a residential home are presented for flyover noise from subsonic and supersonic aircraft. Possible effects on occupant comfort are assessed. The results from these three examples show that aircraft noise can induce structural responses that are large enough to require consideration in the design or operation of the aircraft

Acoustic-loads research for powered-lift configurations

Data presented from large-scale model tests with jet engines having thrusts of 9 kN (2000 lb) and 36 kN (8000 lb) include acoustic loads for an externally blown wing and flap induced by a TF34 jet engine, an upper surface blown (USB) aircraft model in a wind tunnel, and two USB models in static tests. Comparisons of these results with results from acoustic loads studies on configurations of other sizes are made and the implications of these results on interior noise and acoustic fatigue are discussed

Properties of Hot Stars in the Wolf-Rayet galaxy NGC5253 from ISO Spectroscopy

ISO-SWS spectroscopy of the WR galaxy NGC5253 is presented, and analysed to provide estimates of its hot young star population. Our approach differs from previous investigations in that we are able to distinguish between the regions in which different infrared fine-structure lines form, using complementary ground-based observations. The high excitation nebular [SIV] emission is formed in a very compact region, which we attribute to the central super-star-nucleus, and lower excitation [NeII] nebular emission originates in the galactic core. We use photo-ionization modelling coupled with the latest theoretical O-star flux distributions to derive effective stellar temperatures and ionization parameters of Teff>38kK, logQ=8.25 for the compact nucleus, with Teff=35kK, logQ<8 for the larger core. Results are supported by more sophisticated calculations using evolutionary synthesis models. We assess the contribution that Wolf-Rayet stars may make to highly ionized nebular lines (e.g. [OIV]). From our Br(alpha) flux, the 2" nucleus contains the equivalent of approximately 1000 O7V star equivalents and the starburst there is 2-3Myr old; the 20" core contains about 2500 O7V star equivalents, with a representative age of 5Myr. The Lyman ionizing flux of the nucleus is equivalent to the 30 Doradus region. These quantities are in good agreement with the observed mid-IR dust luminosity of 7.8x10^8 L(sun) Since this structure of hot clusters embedded in cooler emission may be common in dwarf starbursts, observing a galaxy solely with a large aperture may result in confusion. Neglecting the spatial distribution of nebular emission in NGC5253, implies `global' stellar temperatures (or ages) of 36kK (4.8Myr) and 39kK (2.9 or 4.4Myr) from the observed [NeIII/II] and [SIV/III] line ratios, assuming logQ=8.Comment: 16 pages, 7 figures, uses mn.sty, to appear in MNRA

Complex networks created by aggregation

We study aggregation as a mechanism for the creation of complex networks. In this evolution process vertices merge together, which increases the number of highly connected hubs. We study a range of complex network architectures produced by the aggregation. Fat-tailed (in particular, scale-free) distributions of connections are obtained both for networks with a finite number of vertices and growing networks. We observe a strong variation of a network structure with growing density of connections and find the phase transition of the condensation of edges. Finally, we demonstrate the importance of structural correlations in these networks.Comment: 12 pages, 13 figure