501 research outputs found
Developmental imaging genetics: challenges and promises for translational research
Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework. Herein, we begin by outlining an experimental strategy by which genetic effects on brain function can be explored using neuroimaging, namely, imaging genetics. We next describe some major findings in imaging genetics to highlight the effectiveness of this strategy for delineating biological pathways and mechanisms by which individual differences in brain function emerge and potentially bias behavior and risk for psychiatric illness. We then discuss the importance of applying imaging genetics to the study of psychopathology within a developmental framework. By beginning to move toward a systems-level approach to understanding pathways to behavioral outcomes as they are expressed across development, it is anticipated that we will move closer to understanding the complexities of the specific mechanisms involved in the etiology of psychiatric disease. Despite the numerous challenges that lie ahead, we believe that developmental imaging genetics has potential to yield highly informative results that will ultimately translate into public health benefits. We attempt to set out guidelines and provide exemplars that may help in designing fruitful translational research applications that incorporate a developmental imaging genetics strategy
Constraints on short, hard gamma-ray burst beaming angles from gravitational wave observations
The first detection of a binary neutron star merger, GW170817, and an associated short gamma-ray burst confirmed that neutron star mergers are responsible for at least some of these bursts. The prompt gamma-ray emission from these events is thought to be highly relativistically beamed. We present a method for inferring limits on the extent of this beaming by comparing the number of short gamma-ray bursts (SGRBs) observed electromagnetically with the number of neutron star binary mergers detected in gravitational waves. We demonstrate that an observing run comparable to the expected Advanced LIGO (aLIGO) 2016–2017 run would be capable of placing limits on the beaming angle of approximately \theta \in (2\buildrel{\circ}\over{.} 88,14\buildrel{\circ}\over{.} 15), given one binary neutron star detection, under the assumption that all mergers produce a gamma-ray burst, and that SGRBs occur at an illustrative rate of . We anticipate that after a year of observations with aLIGO at design sensitivity in 2020, these constraints will improve to \theta \in (8\buildrel{\circ}\over{.} 10,14\buildrel{\circ}\over{.} 95), under the same efficiency and SGRB rate assumptions
Model comparison from LIGO-Virgo data on GW170817's binary components and consequences for the merger remnant
Model comparison from LIGO-Virgo data on GW170817's binary components and consequences for the merger remnant
Foliations of Isonergy Surfaces and Singularities of Curves
It is well known that changes in the Liouville foliations of the isoenergy
surfaces of an integrable system imply that the bifurcation set has
singularities at the corresponding energy level. We formulate certain
genericity assumptions for two degrees of freedom integrable systems and we
prove the opposite statement: the essential critical points of the bifurcation
set appear only if the Liouville foliations of the isoenergy surfaces change at
the corresponding energy levels. Along the proof, we give full classification
of the structure of the isoenergy surfaces near the critical set under our
genericity assumptions and we give their complete list using Fomenko graphs.
This may be viewed as a step towards completing the Smale program for relating
the energy surfaces foliation structure to singularities of the momentum
mappings for non-degenerate integrable two degrees of freedom systems.Comment: 30 pages, 19 figure
Tests of General Relativity with the Binary Black Hole Signals from the LIGO-Virgo Catalog GWTC-1
Search for the isotropic stochastic background using data from Advanced LIGO’s second observing run
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