Developmental imaging genetics: challenges and promises for translational research

Advances in molecular biology, neuroimaging, genetic epidemiology, and developmental psychopathology have provided a unique opportunity to explore the interplay of genes, brain, and behavior within a translational research framework. Herein, we begin by outlining an experimental strategy by which genetic effects on brain function can be explored using neuroimaging, namely, imaging genetics. We next describe some major findings in imaging genetics to highlight the effectiveness of this strategy for delineating biological pathways and mechanisms by which individual differences in brain function emerge and potentially bias behavior and risk for psychiatric illness. We then discuss the importance of applying imaging genetics to the study of psychopathology within a developmental framework. By beginning to move toward a systems-level approach to understanding pathways to behavioral outcomes as they are expressed across development, it is anticipated that we will move closer to understanding the complexities of the specific mechanisms involved in the etiology of psychiatric disease. Despite the numerous challenges that lie ahead, we believe that developmental imaging genetics has potential to yield highly informative results that will ultimately translate into public health benefits. We attempt to set out guidelines and provide exemplars that may help in designing fruitful translational research applications that incorporate a developmental imaging genetics strategy

NASA automatic subject analysis technique for extracting retrievable multi-terms (NASA TERM) system

Current methods for information processing and retrieval used at the NASA Scientific and Technical Information Facility are reviewed. A more cost effective computer aided indexing system is proposed which automatically generates print terms (phrases) from the natural text. Satisfactory print terms can be generated in a primarily automatic manner to produce a thesaurus (NASA TERMS) which extends all the mappings presently applied by indexers, specifies the worth of each posting term in the thesaurus, and indicates the areas of use of the thesaurus entry phrase. These print terms enable the computer to determine which of several terms in a hierarchy is desirable and to differentiate ambiguous terms. Steps in the NASA TERMS algorithm are discussed and the processing of surrogate entry phrases is demonstrated using four previously manually indexed STAR abstracts for comparison. The simulation shows phrase isolation, text phrase reduction, NASA terms selection, and RECON display

Older people's experiences of changed medication appearance : a survey

This report details a survey of older people's experiences of changed medication appearance. The aims of the study were: • To develop a questionnaire in partnership with older people to survey older people’s views on fluctuating medication appearance • To elicit older people’s experiences of medication that changed appearance due to ‘generic prescribing’ and ‘parallel import’ practices and its impact on their medication taking practices. These common pharmacy practices mean that the same tablet medication can be issued to older people in different colours, sizes and shapes to their previous prescriptions. Older people from a local User/Carer Forum highlighted these problems to the research team and asked that we investigate to explore the extent of the problem. An eight-item questionnaire was developed and distributed to 2000 older people (50 years+) across participating PCTs in Greater Manchester in 2008. A 29% response rate was achieved. The data was analysed using the SPSS statistical package. Findings include: •63.3% experienced a change in the appearance of their tablet medications. •74.1% did not seek advice regarding the change in the appearance of their tablet medications. •Older people noted changes to the actual tablets, tablet packaging and written information that accompanies tablets. Changes are occurring to the colour, size and shape of tablets more than changes to packaging and written information. The majority of respondents had experienced changes in the appearance of their prescribed tablet medication in the previous two years which were not due to change in medication or dose etc. Worryingly, for some respondents, these changes prompted negative experiences such as anxiety, confusion and upset. Of particular concern was that a small number omitted the affected tablet medications and did not seek help or advice from GPs, pharmacists or relatives. Six older people have been study advisors from inception to dissemination of this study and significantly added to its quality. The study demonstrates substantive public engagement / user involvement in research. The findings suggest nurses and others have a role to play in promoting better medicines management and identifying those most at risk from changed appearance of medications

Mapping suspended particle and solute concentrations from satellite data

There are no author-identified significant results in this report

Revision of geodetic parameters

Laser data from nine satellites and 12 stations are combined with surface-gravity data to obtain spherical harmonics representing the geopotential complete through degree and order 18. This laser-data-only solution provides a reasonable improvement to the gravity field

Anomalous enhancement of a penguin hadronic matrix element in B->K eta'

We estimate the density matrix element for the pi^0, eta and eta' production from the vacuum in the large-N_c limit. As a consequence, we find that the QCD axial anomaly leads to highly non-trivial corrections to the usual flavour SU(3) relations between B^0-> K^0 pi^0, B^0-> K^0 eta and B^0-> K^0 eta' decay amplitudes. These corrections may explain why the B-> K eta' branching ratio is about six times larger than the B-> K pi one.Comment: 5 pages, 1 figur