1,149 research outputs found
Nature of Sonoluminescence: Noble Gas Radiation Excited by Hot Electrons in "Cold" Water
We show that strong electric fields occurring in water near the surface of
collapsing gas bubbles because of the flexoelectric effect can provoke dynamic
electric breakdown in a micron-size region near the bubble and consider the
scenario of the SBSL. The scenario is: (i) at the last stage of incomplete
collapse of the bubble the gradient of pressure in water near the bubble
surface has such a value and sign that the electric field arising from the
flexoelectric effect exceeds the threshold field of the dynamic electrical
breakdown of water and is directed to the bubble center; (ii) mobile electrons
are generated because of thermal ionization of water molecules near the bubble
surface; (iii) these electrons are accelerated in ''cold'' water by the strong
electric fields; (iv) these hot electrons transfer noble gas atoms dissolved in
water to high-energy excited states and optical transitions between these
states produce SBSL UV flashes in the trasparency window of water; (v) the
breakdown can be repeated several times and the power and duration of the UV
flash are determined by the multiplicity of the breakdowns. The SBSL spectrum
is found to resemble a black-body spectrum where temperature is given by the
effective temperature of the hot electrons. The pulse energy and some other
characteristics of the SBSL are found to be in agreement with the experimental
data when realistic estimations are made.Comment: 11 pages (RevTex), 1 figure (.ps
Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex
BACKGROUND:
Common variants in the TCF4 gene are among the most robustly supported genetic risk factors for schizophrenia. Rare TCF4 deletions and loss-of-function point mutations cause Pitt-Hopkins syndrome, a developmental disorder associated with severe intellectual disability.
METHODS:
To explore molecular and cellular mechanisms by which TCF4 perturbation could interfere with human cortical development, we experimentally reduced the endogenous expression of TCF4 in a neural progenitor cell line derived from the developing human cerebral cortex using RNA interference. Effects on genome-wide gene expression were assessed by microarray, followed by Gene Ontology and pathway analysis of differentially expressed genes. We tested for genetic association between the set of differentially expressed genes and schizophrenia using genome-wide association study data from the Psychiatric Genomics Consortium and competitive gene set analysis (MAGMA). Effects on cell proliferation were assessed using high content imaging.
RESULTS:
Genes that were differentially expressed following TCF4 knockdown were highly enriched for involvement in the cell cycle. There was a nonsignificant trend for genetic association between the differentially expressed gene set and schizophrenia. Consistent with the gene expression data, TCF4 knockdown was associated with reduced proliferation of cortical progenitor cells in vitro.
LIMITATIONS:
A detailed mechanistic explanation of how TCF4 knockdown alters human neural progenitor cell proliferation is not provided by this study.
CONCLUSION:
Our data indicate effects of TCF4 perturbation on human cortical progenitor cell proliferation, a process that could contribute to cognitive deficits in individuals with Pitt-Hopkins Syndrome and risk for schizophrenia
On the nature of the z=0 X-ray absorbers: I. Clues from an external group
Absorption lines of OVII at redshift zero are observed in high quality
Chandra spectra of extragalactic sightlines. The location of the absorber
producing these lines, whether from the corona of the Galaxy or from the Local
Group or even larger scale structure, has been a matter of debate. Here we
study another poor group like our Local Group to understand the distribution of
column density from galaxy to group scales. We show that we cannot yet rule out
the group origin of z=0 systems. We further argue that the debate over Galactic
vs. extragalactic origin of z=0 systems is premature as they likely contain
both components and predict that future higher resolution observations will
resolve the z=0 systems into multiple components.Comment: Submitted to ApJ
Persistent currents in a circular array of Bose-Einstein condensates
A ring-shaped array of Bose-Einstein condensed atomic gases can display
circular currents if the relative phase of neighboring condensates becomes
locked to certain values. It is shown that, irrespective of the mechanism
responsible for generating these states, only a restricted set of currents are
stable, depending on the number of condensates, on the interaction and
tunneling energies, and on the total number of particles. Different
instabilities due to quasiparticle excitations are characterized and possible
experimental setups for testing the stability prediction are also discussed.Comment: 7 pages, REVTex
Recommended from our members
Propagation of short-period gravity waves at high-latitudes during the MaCWAVE winter campaign
As part of the MaCWAVE (Mountain and Convective Waves Ascending Vertically) winter campaign an all-sky monochromatic CCD imager has been used to investigate the properties of short-period mesospheric gravity waves at high northern latitudes. Sequential measurements of several nightglow emissions were made from Esrange, Sweden, during a limited period from 27–31 January 2003. Coincident wind measurements over the altitude range (~80–100 km) using two meteor radar systems located at Esrange and Andenes have been used to perform a novel investigation of the intrinsic properties of five distinct wave events observed during this period. Additional lidar and MSIS model temperature data have been used to investigate their nature (i.e. freely propagating or ducted). Four of these extensive wave events were found to be freely propagating with potential source regions to the north of Scandinavia. No evidence was found for strong orographic forcing by short-period waves in the airglow emission layers. The fifth event was most unusual exhibiting an extensive, but much smaller and variable wavelength pattern that appeared to be embedded in the background wind field. Coincident wind measurements indicated the presence of a strong shear suggesting this event was probably due to a large-scale Kelvin-Helmholtz instability
Entangled quantum tunneling of two-component Bose-Einstein condensates
We examine the quantum tunneling process in Bose condensates of two
interacting species trapped in a double well configuration. We discover the
condition under which particles of different species can tunnel as pairs
through the potential barrier between two wells in opposition directions. This
novel form of tunneling is due to the interspecies interaction that eliminates
the self- trapping effect. The correlated motion of tunneling atoms leads to
the generation of quantum entanglement between two macroscopically coherent
systems.Comment: 4 pages, 3 figure
Dietary lecithin improves the healthiness of pork
Dietary lecithin may provide health benefits to pork as well as improving its eating quality by reducing chewiness and hardness (D'Souza et al.., 2005). Human studies have shown lecithin supplementation can reduce cholesterol significantly (Spilburg et al., 2003) and we hypothesised that lecithin supplementation would have a similar effect in pigs. The use of lecithin supplementation to improve the 'healthiness' of pork or pork products, while also improving the tenderness of pork, could provide the pork industry with significant marketing opportunities. The aim of this experiment was to investigate the effect of lecithin supplementation on the fatty acid profile of pork and also on the plasma cholesterol of pigs
Multiwavelength Study of M8.9/3B Solar Flare from AR NOAA 10960
We present a multi-wavelength analysis of a long duration white-light solar
flare (M8.9/3B) event that occurred on 4 June 2007 from NOAA AR 10960. The
flare was observed by several spaceborne instruments, namely SOHO/MDI,
Hinode/SOT, TRACE and STEREO/SECCHI. The flare was initiated near a small,
positive-polarity, satellite sunspot at the centre of the AR, surrounded by
opposite-polarity field regions. MDI images of the AR show considerable amount
of changes in a small positive-polarity sunspot of delta configuration during
the flare event. SOT/G-band (4305 A) images of the sunspot also suggest the
rapid evolution of the positive-polarity sunspot with highly twisted penumbral
filaments before the flare event, which were oriented in the counterclockwise
direction. It shows the change in orientation and also remarkable disappearance
of twisted penumbral filaments (~35-40%) and enhancement in umbral area
(~45-50%) during the decay phase of the flare. TRACE and SECCHI observations
reveal the successive activations of two helical twisted structures associated
with this sunspot, and the corresponding brightening in the chromosphere as
observed by the time-sequence images of SOT/Ca II H line (3968 A). The
secondary-helical twisted structure is found to be associated with the M8.9
flare event. The brightening starts 6-7 min prior to the flare maximum with the
appearance of secondary helical-twisted structure. The flare intensity
maximizes as this structure moves away from the AR. This twisted flux-tube
associated with the flare triggering, is found to be failed in eruption. The
location of the flare is found to coincide with the activation site of the
helical twisted structures. We conclude that the activations of successive
helical twists in the magnetic flux tubes/ropes plays a crucial role in the
energy build-up process and triggering of M-class solar flare without a CME.Comment: 22 pages, 12 figures, Accepted for Publication in Solar Physic
A Planck-scale axion and SU(2) Yang-Mills dynamics: Present acceleration and the fate of the photon
From the time of CMB decoupling onwards we investigate cosmological evolution
subject to a strongly interacting SU(2) gauge theory of Yang-Mills scale
eV (masquerading as the factor of the SM at
present). The viability of this postulate is discussed in view of cosmological
and (astro)particle physics bounds. The gauge theory is coupled to a spatially
homogeneous and ultra-light (Planck-scale) axion field. As first pointed out by
Frieman et al., such an axion is a viable candidate for quintessence, i.e.
dynamical dark energy, being associated with today's cosmological acceleration.
A prediction of an upper limit for the duration of the
epoch stretching from the present to the point where the photon starts to be
Meissner massive is obtained: billion years.Comment: v3: consequences of an error in evolution equation for coupling
rectified, only a minimal change in physics results, two refs. adde
Macroscopic Quantum Fluctuations in the Josephson Dynamics of Two Weakly Linked Bose-Einstein Condensates
We study the quantum corrections to the Gross-Pitaevskii equation for two
weakly linked Bose-Einstein condensates. The goals are: 1) to investigate
dynamical regimes at the borderline between the classical and quantum behaviour
of the bosonic field; 2) to search for new macroscopic quantum coherence
phenomena not observable with other superfluid/superconducting systems. Quantum
fluctuations renormalize the classical Josephson oscillation frequencies. Large
amplitude phase oscillations are modulated, exhibiting collapses and revivals.
We describe a new inter-well oscillation mode, with a vanishing (ensemble
averaged) mean value of the observables, but with oscillating mean square
fluctuations. Increasing the number of condensate atoms, we recover the
classical Gross-Pitaevskii (Josephson) dynamics, without invoking the
symmetry-breaking of the Gauge invariance.Comment: Submitte
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