Wade McCree\u27s Michigan Legacy

A Tribute to Wade H. McCree, Jr

The effect of Korean pine nut oil (PinnoThin™) on food intake, feeding behaviour and appetite: A double-blind placebo-controlled trial

Certain free fatty acids have been shown to have potent effects on food intake and self-reported changes in appetite; effects associated with increases in the release of endogenous cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1). In the current study, the effects of a Korean pine nut oil product, PinnoThin™, at doses 2 g, 4 g and 6 g triglyceride (TG) and 2 g free fatty acid (FFA), on food intake and appetite were examined in a cross-over double-blind placebo-controlled randomised counter-balanced design in 42 overweight female volunteers. 2 g FFA PinnoThin™, given 30 minutes prior to an ad-libitum buffet test lunch, significantly reduced food intake (gram) by 9% (F(4,164) = 2.637, p = 0.036) compared to olive oil control. No significant effect of PinnoThin™ on macronutrient intake or ratings of appetite were observed. Given the recent data showing that the TG form of PinnoThin™ may also reduce appetite by increasing CCK release, the lack of any effect of the TG form found in this study could be attributed to the timing of the dosing regime. Collectively, these data suggest that PinnoThin™ may exert satiating effects consistent with its known action on CCK and GLP-1 release, and previously observed effects on self-reported appetite ratings

SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic functions of antibodies are associated with improved disease outcome and vaccine protection, Fc effector function escape from VOCs is poorly defined. Furthermore, whether VOCs trigger Fc functions with altered specificity, as has been reported for neutralization, is unknown. Here, we demonstrate that the Beta VOC partially evades Fc effector activity in individuals infected with the original (D614G) variant. However, not all functions are equivalently affected, suggesting differential targeting by antibodies mediating distinct Fc functions. Furthermore, Beta and Delta infection trigger responses with significantly improved Fc cross-reactivity against global VOCs compared with D614G-infected or Ad26.COV2.S-vaccinated individuals. This suggests that, as for neutralization, the infecting spike sequence affects Fc effector function. These data have important implications for vaccine strategies that incorporate VOCs, suggesting these may induce broader Fc effector responses.The EDCTP2 program of the European Union’s Horizon 2020 program, Wellcome Centre for Infectious Diseases Research in Africa, the SA-MRC, MRC UK, NRF, the Lily and Ernst Hausmann Trust, the South African Research Chairs Initiative of the Department of Science and Innovation and National Research Foundation of South Africa, the SA Medical Research Council SHIP program, the Center for the AIDS Program of Research (CAPRISA) and an L’Oreal/UNESCO Women in Science South Africa Young Talents award.http://www.cell.com/cell-host-microbe/homeam2023ImmunologyInternal Medicin

Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern

The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding antibody responses to Ad26.COV2.S vaccination are stable for 6 months post-vaccination, when tested against multiple SARS-CoV-2 variants. Secondly, using longitudinal samples from individuals who experienced clinically mild breakthrough infections 4 to 5 months after vaccination, we show dramatically boosted binding antibodies, Fc effector function, and neutralization. These high titer responses are of similar magnitude to humoral immune responses measured in convalescent donors who had been hospitalized with severe illness, and are cross-reactive against diverse SARS-CoV-2 variants, including the neutralizationresistant Omicron (B.1.1.529) variant that currently dominates global infections, as well as SARS-CoV-1. These data have implications for population immunity in areas where the Ad26.COV2.S vaccine has been widely deployed, but where ongoing infections continue to occur at high levels.The South African Medical Research Council, the South African Research Chairs Initiative of the Department of Science and Innovation; the National Research Foundation of South Africa, the EDCTP2 program of the European Union’s Horizon 2020 program, the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), which is supported by core funding from the Wellcome Trust and the Poliomyelitis Research Foundation, MRC UK, NRF, the Lily and Ernst Hausmann Trust and L’Oreal/Unesco Women in Science South Africa Young Talents awardee.http://www.cell.com/cell-host-microbe/homeImmunologyInternal Medicin

Sound Recording - Address by John F. Kennedy at Michigan State University - 1960 October 14

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Item 92] : [Part 1] : Campaign speech by John F. Kennedy at Michigan State, Williams, Swainson and others. Introductory remarks by John B. Swainson, Jerry Earhart?http://deepblue.lib.umich.edu/bitstream/2027.42/121476/2/86393-SR-92-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121476/3/86393-SR-92-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121476/4/86393-SR-92-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/121476/5/86393-SR-92-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121476/6/86393-SR-92-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121476/7/86393-SR-92-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121476/8/86393-SR-92-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/121476/9/86393-SR-92-1.xmlRESTRICTE

G. Mennen Williams, Campaign Rally Address, 1966

G. Mennen Williams (1911-1988) was the 41st Governor of Michigan, and later worked under John F. Kennedy as Assistant Secretary of State for African Affairs, and served as Chief Justice of the Michigan Supreme Court. In 1966, Williams unsuccessfully ran for Governor of Michigan. This audio recording captures Williams in a campaign stop, introducing primary speaker Robert Kennedy.https://commons.emich.edu/speeches/1031/thumbnail.jp

Sound Recording - Talking Point (television program of Republican State Central Committee) - 1958 June 23

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Item 36] : [Part 1] : Discussion of the UAW-control of G. Mennen Williams and Kohler strike (John Gunaca)http://deepblue.lib.umich.edu/bitstream/2027.42/121466/2/86393-SR-36-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121466/3/86393-SR-36-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121466/4/86393-SR-36-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/121466/5/86393-SR-36-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121466/6/86393-SR-36-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121466/7/86393-SR-36-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121466/8/86393-SR-36-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/121466/9/86393-SR-36-1.xmlRESTRICTE

Sound Recording - Campaign radio address - 1952

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Item 10] : [Part 1] : Williams discusses his political goals during the 1952 gubernatorial campaign.http://deepblue.lib.umich.edu/bitstream/2027.42/121453/2/86393-SR-10-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121453/3/86393-SR-10-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121453/4/86393-SR-10-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/121453/5/86393-SR-10-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121453/6/86393-SR-10-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121453/7/86393-SR-10-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121453/8/86393-SR-10-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/121453/9/86393-SR-10-1.xmlRESTRICTE

Sound Recording - Foreign policy briefing; [Unknown Address by G. Mennen Williams] - 1958 April 12

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Item 62] : [Part 1] : [Segment 1] : Tape 2; Unknown speakers discuss political and economic differences between the U.S. and the U.S.S.R. and U.S. foreign policy and the rise of Communism throughout the world.[Item 62] : [Part 1] : [Segment 2] : Williams discusses Veterans support, unemployment, and the economy.http://deepblue.lib.umich.edu/bitstream/2027.42/121468/2/86393-SR-62-1-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/3/86393-SR-62-1-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/4/86393-SR-62-1-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/121468/5/86393-SR-62-1-2-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/6/86393-SR-62-1-2-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/7/86393-SR-62-1-2.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/121468/8/86393-SR-62-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/9/86393-SR-62-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/10/86393-SR-62-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/11/86393-SR-62-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/121468/12/86393-SR-62-1.xmlRESTRICTE

Sound Recording - Talking Point (television program of Republican State Central Committee) - 1956 June 09

Content note: The sound recording(s) associated with this repository item derive from a single audio reel tape. A single tape may yield multiple audio files if there were variations in tape stock, speed, or channels (i.e. stereo or mono). For more information see http://hdl.handle.net/2027.42/108126.[Item 34] : [Part 1] : Discussion of the Republican Party and labor movement; and philosophy of Republican Party.http://deepblue.lib.umich.edu/bitstream/2027.42/121465/2/86393-SR-34-1-am.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121465/3/86393-SR-34-1-pm.wavhttp://deepblue.lib.umich.edu/bitstream/2027.42/121465/4/86393-SR-34-1.mp3http://deepblue.lib.umich.edu/bitstream/2027.42/121465/5/86393-SR-34-1-003.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121465/6/86393-SR-34-1-002.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121465/7/86393-SR-34-1-001.jpghttp://deepblue.lib.umich.edu/bitstream/2027.42/121465/8/86393-SR-34-1-notes.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/121465/9/86393-SR-34-1.xmlRESTRICTE