Technological Issues: The Citizen Initiated Performance Assessment (CIPA) Initiative through Wireless Technology

Many governments, including my own that serves a population of about 200,000 Central Iowans, have been reluctant to invest in technologies supporting e-government services. The operating assumption for this reluctance is that the digital divide delivers the benefits of e-government to the wealthiest and often most educated citizens, effectively diverting resources to constituencies traditionally less reliant on government services than the poor who are often left on the down side of the digital divide . While digital divide considerations are and should continue to be a focal point in deciding allocation of scarce financial resources supporting technological improvements, reallocation of resources to bridge the digital divide should be a countervailing consideration in debates about the impact of e-government. Without doubt, this use of technologies to communicate citizen requests for service is more direct and arguably more effective than the process available to more affluent residents, effectively using technologies to turn the digital divide to the advantage of those less likely to have ready access to their own technologies

The Last Digits of Infinity (On Tetrations Under Modular Rings)

A tetration is defined as repeated exponentiation. As an example, 2 tetrated 4 times is 2^(2^(2^2)) = 2^16. Tetrated numbers grow rapidly; however, we will see that when tetrating where computations are performed mod n for some positive integer n, there is convergent behavior. We will show that, in general, this convergent behavior will always show up

The influence of side vent length on instrument flexural fatigue of three endodontic irrigating needles

The purpose of this in-vitro study was to compare the influence of the side vent length on flexural fatigue and subsequent failure of three endodontic irrigating needles. Twenty ProRinse Endodontic Irrigation Probes, twenty-three Max-i-Probes, and twenty Vista-Probe Irrigating Tips were used in this study. All three irrigating needles are 30-gauge, have a side-vented port, and are safe-ended. After all side vent lengths were measured and recorded, each needle was subjected to flexing cycles of 30° until flexural fatigue occurred and the instrument permanently failed. Data were analyzed using a one-way ANOVA and Tukey HSD test. Results indicate the Vista-Probe required a significantly greater number of cycles to produce flexural fatigue as compared to the ProRinse and Max-i-Probe irrigating probes (p \u3c .0001). However, the length of the side vent as it relates to flexural fatigue within each individual needle group did not appear to be statistically significant (p \u3e .05)

Letter from William Stowe,Boston. Massachusetts, to George S. Pratt, New York, New York, 1900 December 14

https://repository.wellesley.edu/whitney_correspondence/2085/thumbnail.jp

Damage to Mitochondrial Complex I During Cardiac Ischemia Reperfusion Injury is Reduced Indirectly by Anti-anginal Drug Ranolazine

Ranolazine, an anti-anginal drug, is a late Na+ channel current blocker that is also believed to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially during ischemia. In this study, we investigated if ranolazine\u27s protective effect against cardiac ischemia/reperfusion (IR) injury is mediated at the mitochondrial level and specifically if respiratory complex I (NADH Ubiquinone oxidoreductase) function is protected. We treated isolated and perfused guinea pig hearts with ranolazine just before 30 min ischemia and then isolated cardiac mitochondria at the end of 30 min ischemia and/or 30 min ischemia followed by 10 min reperfusion. We utilized spectrophotometric and histochemical techniques to assay complex I activity, Western blot analysis for complex I subunit NDUFA9, electron paramagnetic resonance for activity of complex I Fe–S clusters, enzyme linked immuno sorbent assay (ELISA) for determination of protein acetylation, native gel histochemical staining for respiratory supercomplex assemblies, and high pressure liquid chromatography for cardiolipin integrity; cardiac function was measured during IR. Ranolazine treated hearts showed higher complex I activity and greater detectable complex I protein levels compared to untreated IR hearts. Ranolazine treatment also led to more normalized electron transfer via Fe–S centers, supercomplex assembly and cardiolipin integrity. These improvements in complex I structure and function with ranolazine were associated with improved cardiac function after IR. However, these protective effects of ranolazine are not mediated by a direct action on mitochondria, but rather indirectly via cytosolic mechanisms that lead to less oxidation and better structural integrity of complex I

Rationale and Methods for a Multicenter Clinical Trial Assessing Exercise and Intensive Vascular Risk Reduction in Preventing Dementia (rrAD Study)

Alzheimer\u27s Disease (AD) is an age-related disease with modifiable risk factors such as hypertension, hypercholesterolemia, obesity, and physical inactivity influencing the onset and progression. There is however, no direct evidence that reducing these risk factors prevents or slows AD. The Risk Reduction for Alzheimer\u27s Disease (rrAD) trial is designed to study the independent and combined effects of intensive pharmacological control of blood pressure and cholesterol and exercise training on neurocognitive function. Six hundred and forty cognitively normal older adults age 60 to 85 years with hypertension and increased risk for dementia will be enrolled. Participants are randomized into one of four intervention group for two years: usual care, Intensive Reduction of Vascular Risk factors (IRVR) with blood pressure and cholesterol reduction, exercise training (EX), and IRVR+EX. Neurocognitive function is measured at baseline, 6, 12, 18, and 24 months; brain MRIs are obtained at baseline and 24 months. We hypothesize that both IRVR and EX will improve global cognitive function, while IRVR+EX will provide a greater benefit than either IRVR or EX alone. We also hypothesize that IRVR and EX will slow brain atrophy, improve brain structural and functional connectivity, and improve brain perfusion. Finally, we will explore the mechanisms by which study interventions impact neurocognition and brain. If rrAD interventions are shown to be safe, practical, and successful, our study will have a significant impact on reducing the risks of AD in older adults. NCT Registration: NCT02913664

Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.

BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. METHODS AND RESULTS:Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home-based activity data were collected by hip-worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [SD] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84-0.96; P=0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65-0.89 [P=0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow-up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85-0.96 [P=0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidence interval, 0.63-0.90 [P=0.002]) were significantly associated with lower cardiovascular event rates. CONCLUSIONS:Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score >10 on the Short Physical Performance Battery) both using baseline and longitudinal data. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01072500