77 research outputs found
Circadian Disruption, \u3cem\u3ePer3\u3c/em\u3e, and Human Cytokine Secretion
Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n=70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-I ra, IL-I-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role
Age-Dependent NOC/oFQ Contribution to Impaired Hypotensive Cerebral Hemodynamics after Brain Injury
Dopamine Prevents Impairment of Autoregulation After Traumatic Brain Injury in the Newborn Pig Through Inhibition of Up-regulation of Endothelin-1 and Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase
Relationship between nociceptin/orphanin FQ and cerebral hemodynamics after hypoxia-ischemia in piglets
NOC/oFQ PKC-dependent superoxide generation contributes to hypoxic-ischemic impairment of NMDA cerebrovasodilation
NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury
Role of Nociceptin/Orphanin FQ in Age-Dependent Cerebral Hemodynamic Effects of Brain Injury
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