A Malthusian Analysis of the So-Called Dynasty Trust

Select financial institutions and members of the Bar have seized upon the presence of the limited exemption from the generation skipping transfer tax provided under the Internal Revenue Code to promote so-called dynasty trusts as a means whereby individuals can build dynastic wealth for a family forever free from transfer taxes. To realize such benefits, state law that does not impose the Rule Against Perpetuities must govern the trust. The promise of dynastic wealth is unlikely to be realized due to several factors. Administrative and tax costs are likely to reduce the yield on such trusts to a level where inflation, rising expectations, and an ever growing band of beneficiaries are typically assured to outpace the ability of the trust to deliver the benefits anticipated by trust settlors. Whether required under current standards of professional responsibility or not, an understanding of these factors can elevate the quality of service provided by estate planners

A Malthusian Analysis of the So-Called Dynasty Trust

Select financial institutions and members of the Bar have seized upon the presence of the limited exemption from the generation skipping transfer tax provided under the Internal Revenue Code to promote so-called dynasty trusts as a means whereby individuals can build dynastic wealth for a family forever free from transfer taxes. To realize such benefits, state law that does not impose the Rule Against Perpetuities must govern the trust. The promise of dynastic wealth is unlikely to be realized due to several factors. Administrative and tax costs are likely to reduce the yield on such trusts to a level where inflation, rising expectations, and an ever growing band of beneficiaries are typically assured to outpace the ability of the trust to deliver the benefits anticipated by trust settlors. Whether required under current standards of professional responsibility or not, an understanding of these factors can elevate the quality of service provided by estate planners

Different intra- and inter-molecular hydrogen-bonding patterns in (3S,4aS,8aS)-2-[(2R,3S)-3-(2,5-X2-benzamido)-2-(2,5-X2-benzo-yloxy)-4-phenyl-butyl]-N-tert-butyldeca-hydro-iso-quinoline-3-carboxamides (X = H or Cl) : compounds with moderate aspartyl protease inhibition activity

We thank the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collections.Peer reviewedPublisher PD

Crystal structures of four indole derivatives as possible cannabinoid allosteric antagonists

Acknowledgements We thank the EPSRC National Crystallography Service (University of Southampton) for the data collections and the EPSRC National Mass Spectrometry Service (University of Swansea) for the HRMS data. We thank John Low for carrying out the Cambridge Database survey.Peer reviewedPublisher PD

Crystal structures of potassium tri­fluorido­(4-meth­oxy­phen­yl)borate and potassium tri­fluorido(4-fluoro­phen­yl)borate

Acknowledgements We thank the National Crystallography Service (University of Southampton) for the data collections.Peer reviewedPublisher PD

Distributed Relation Logic

We extend the relational algebra of Chin and Tarski so that it is multisorted or, as we prefer, typed. Each type supports a local Boolean algebra outfitted with a converse operator. From Lyndon, we know that relation algebras cannot be represented as proper relation algebras where a proper relation algebra has binary relations as elements and the algebra is singly-typed. Here, the intensional conjunction, which was to represent relational composition in Chin and Tarski, spans three different local algebras, thus the term distributed in the title. Since we do not rely on proper relation algebras, we are free to re-express the algebras as typed. In doing so, we allow many different intensional conjunction operators.We construct a typed logic over these algebras, also known as heterogeneous algebras of Birkhoff and Lipson. The logic can be seen as a form of relevance logic with a classical negation connective where the Routley-Meyer star operator is reified as a converse connective in the logic. Relevance logic itself is not typed but our work shows how it can be made so. Some of the properties of classical relevance logic are weakened from Routley-Meyer’s version which is too strong for a logic over relation algebras

Synthesis and crystal structure of calcium hydrogen phosphite, CaHPO3

We thank Kirstie McCombie for collecting the powder pattern, Sarah Ferrandin for collecting the IR spectrum and the EPSRC National Crystallography Service (University of Southampton) for the X-ray data collection. This work was performed, in part, at the Center for Integrated Nanotechnologies, an Office of Science User Facility operated for the US Department of Energy (DOE) Office of Science by Los Alamos National Laboratory (Contract DE-AC52–06 N A25396) and Sandia National Laboratories (Contract DE-NA-0003525).Peer reviewedPublisher PD

Prebiotic Synthesis of Aspartate Using Life’s Metabolism as a Guide

A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite for the synthesis of many other essential biomolecules. Aspartate’s prebiotic synthesis is complicated by the instability of its precursor, oxaloacetate. In this paper, we show that the use of the biologically relevant cofactor pyridoxamine, supported by metal ion catalysis, is sufficiently fast to offset oxaloacetate’s degradation. Cu2+-catalysed transamination of oxaloacetate by pyridoxamine achieves around a 5% yield within 1 h, and can operate across a broad range of pH, temperature, and pressure. In addition, the synthesis of the downstream product β-alanine may also take place in the same reaction system at very low yields, directly mimicking an archaeal synthesis route. Amino group transfer supported by pyridoxal is shown to take place from aspartate to alanine, but the reverse reaction (alanine to aspartate) shows a poor yield. Overall, our results show that the nodal metabolite aspartate and related amino acids can indeed be synthesised via protometabolic pathways that foreshadow modern metabolism in the presence of the simple cofactor pyridoxamine and metal ions