Fenestrated Endovascular Aneurysm Repair versus Snorkel Endovascular Aneurysm Repair: Competing yet Complementary Strategies.

Juxtarenal/pararenal aortic aneurysms and type IV thoracoabdominal aneurysms pose particular technical challenges for endovascular repair as they involve the visceral segment in addition to insufficient infrarenal neck for the use of standard endovascular aneurysm repair (EVAR) devices. To overcome these challenges, complex EVAR techniques have been developed to extend the proximal landing zone cephalad with maintaining perfusion to vital aortic branches, thereby broadening the applicability of endografting from the infrarenal to the suprarenal aorta. Complex EVAR can be divided into two broad categories: fenestrated endovascular aneurysm repair (FEVAR) and snorkel EVAR. FEVAR is a valid procedure with the standardized procedure, although it remains as a relatively complex procedure with a learning curve. Given time constraints for the custom fenestrated graft, snorkel EVAR may be an alternative for complex repairs in symptomatic or ruptured patients for whom custom-made endografts may not be immediately available. This article discusses these two most commonly used complex EVAR strategies

Evaluating the Role of Brown vs. Board of Education in School Equalization, Desegregation, and the Income of African Americans

In this paper we study the long-term labor market implications of school resource equalization before Brown and school desegregation after Brown. For cohorts born in the South in the 1920s and 1930s, we find that racial disparities in measurable school characteristics had a substantial influence on black males' earnings and educational attainment measured in 1970, albeit one that was smaller in the later cohorts. When we examine the income of male workers in 1990, we find that southern-born blacks who finished their schooling just before effective desegregation occurred in the South fared poorly compared to southern-born blacks who followed behind them in school by just a few years.

Evaluating the Role of Brown vs. Board of Education in School Equalization,

In this paper we study the long-term labor market implications of school resource equalization before Brown and school desegregation after Brown. For cohorts born in the South in the 1920s and 1930s, we find that racial disparities in measurable school characteristics had a substantial influence on black males’ earnings and educational attainment measured in 1970, albeit one that was smaller in the later cohorts. When we examine the income of male workers in 1990, we find that southern-born blacks who finished their schooling just before effective desegregation occurred in the South fared poorly compared to southern-born blacks who followed behind them in school by just a few years

Rigidity−Stability Relationship in Interlocked Model Complexes Containing Phenylene-Ethynylene-Based Disubstituted Naphthalene and Benzene

Structural rigidity has been found to be advantageous for molecules if they are to find applications in functioning molecular devices. In the search for an understanding of the relationship between the rigidity and complex stability in mechanically interlocked compounds, the binding abilities of two π-electron-rich model compounds (2 and 4), where rigidity is introduced in the form of phenylacetylene units, toward the π-electron deficient tetracationic cyclophane, cyclobis(paraquat-p-phenylene) (CBPQT^(4+)), were investigated. 1,4-Bis(2-(2-methoxyethoxy)ethoxy)-2,5-bis(2-phenylethynyl)benzene 2 and 1,5-bis(2-(2-methoxyethoxy)ethoxy)- 2,6-bis(2-phenylethynyl)naphthalene 4 were synthesized, respectively, from the appropriate precursor dibromides 1 and 3 of benzene and naphthalene carrying two methoxyethoxyethoxy side chains. The rigid nature of the compounds 2 and 4 is reflected in the reduced stabilities of their 1:1 complexes with CBPQT^(4+). Binding constants for both 2 (100 M^(-1)) and 4 (140 M^(-1)) toward CBPQT^(4+) were obtained by isothermal titration microcalorimetry (ITC) in MeCN at 25 °C. Compounds 1-4 were characterized in the solid state by X-ray crystallography. The stabilization within and beyond these molecules is achieved by a combination of intra- and intermolecular [C-H· · · O], [C-H· · ·π], and [π-π] stacking interactions. The diethyleneglycol chains present in compounds 1-4 are folded as a consequence of both intra- and intermolecular hydrogen bonds. The preorganized structures in both precursors 1 and 3 are repeated in both model compounds 2 and 4. In the structures of compounds 2 and 4, the geometry of the rigid backbone is differentsthe two terminal phenyl groups are twisted with respect to the central benzenoid ring in compound 2 and roughly perpendicular to the plane central naphthalene core in compound 4. To understand the significantly decreased stabilities of these complexes toward rigid guest molecules, relative to more flexible systems, we performed density functional theory (DFT) calculations using the newly developed M06-suite of density functionals. We conclude that the reduced binding abilities are a consequence of electronic and not steric factors, originating from the extended delocalization of the aromatic system

Integration of Uncertain Ramp Area Aircraft Trajectories and Generation of Optimal Taxiway Schedules at Charlotte Douglas (CLT) Airport

The integration of aircraft maneuver characteristics into an optimal taxiway scheduling solution is challenging due to the uncertainties that are intrinsic to ramp area aircraft trajectories. To address the challenge, we build a stochastic model of ramp area aircraft trajectories that is used to generate a probabilistic measure of conflict within the Charlotte Douglas International Airport (CLT) ramp area. Parameters of the conflict distributions are estimated and passed to a Mixed Integer Linear Program that solves for an optimal taxiway schedule constrained to be conflict free in the presence of trajectory uncertainties. Here we extend our previous research by accounting for departing and arriving aircraft whereas our prior formulation only accounted for departing aircraft

Prediction of Pushback Times and Ramp Taxi Times for Departures at Charlotte Airport

When optimizing the takeoff sequence and schedule for departures at busy airports, it is important to accurately predict the taxi times from gate to runway because those are used to calculate the earliest possible takeoff times. Several airports like Charlotte Douglas International Airport show relatively long taxi times inside the ramp area with large variations, with respect to the travel times in the airport movement area. Also, the pushback process times have not been accurately modeled so far mainly due to the lack of accurate data. The recent deployment of the integrated arrival, departure, and surface traffic management system at Charlotte airport by NASA enables more accurate flight data in the airport surface operations to be obtained. Taking advantage of this system, actual pushback times and ramp taxi times from historical flight data at this airport are analyzed. Based on the analysis, a simple, data-driven prediction model is introduced for estimating pushback times and ramp transit times of individual departure flights. To evaluate the performance of this prediction model, several machine learning techniques are also applied to the same dataset. The prediction results show that the data-driven prediction model is as good as the machine learning algorithms when comparing various prediction performance metrics

Scheduling Improvements Following the Phase 1 Field Evaluation of the ATD-2 Integrated Arrival, Departure, and Surface Concept

NASA is conducting the Airspace Technology Demonstration-2 to evaluate an Integrated Arrival, Departure, and Surface (IADS) traffic management system that extends traffic sequencing for the entire life-cycle of a flight from departure gate to arrival gate within multi-airport, metroplex environments. After development and testing in human-in-the-loop simulations, the IADS system was deployed to Charlotte Douglas International Airport for a three-year field evaluation. From the initial IADS concept development through the end of the Phase 1 field evaluation many lessons were learned with regards to the IADS scheduler. In this paper we describe how data from the Phase 1 field evaluation helped identify scheduler improvements and guided the implementation of refinements. The improvements in the IADS scheduler described in this paper are incorporated into the IADS Phase 2 scheduler enabling strategic Surface Metering Programs and will be evaluated during the field evaluation

Field Evaluation of the Baseline Integrated Arrival, Departure, and Surface Capabilities at Charlotte Douglas International Airport

NASA is currently developing a suite of decision support capabilities for integrated arrival, departure, and surface (IADS) operations in a metroplex environment. The effort is being made in three phases, under NASA's Airspace Technology Demonstration 2 (ATD-2) sub-project, through a strong partnership with the Federal Aviation Administration (FAA), air carriers, airport, and general aviation community. The Phase 1 Baseline IADS capabilities provide enhanced operational efficiency and predictability of flight operations through data exchange and integration, tactical surface metering, and automated coordination of release time of controlled flights for overhead stream insertion. The users of the IADS system include the personnel at the Charlotte Douglas International Airport (CLT) air traffic control tower, American Airlines ramp tower, CLT terminal radar approach control (TRACON), and Washington Center. This paper describes the Phase 1 Baseline IADS capabilities and field evaluation conducted at CLT from September 2017 for a year. From the analysis of operations data, it is estimated that 538,915 kilograms of fuel savings, and 1,659 metric tons of CO2 emission reduction were achieved during the period with a total of 944 hours of engine run time reduction. The amount of CO2 savings is estimated as equivalent to planting 42,560 urban trees. The results have also shown that the surface metering had no negative impact on on-time arrival performance of both outbound and inbound flights. The technology transfer of Phase 1 Baseline IADS capabilities has been made to the FAA and aviation industry, and the development of additional capabilities for the subsequent phases is underway

Functional Interaction between Herpes Simplex Virus Type 2 gD and HVEM Transiently Dampens Local Chemokine Production after Murine Mucosal Infection

Herpes virus entry mediator (HVEM) is one of two principal receptors mediating herpes simplex virus (HSV) entry into murine and human cells. It functions naturally as an immune signaling co-receptor, and may participate in enhancing or repressing immune responses depending on the natural ligand used. To investigate whether engagement of HVEM by HSV affects the in vivo response to HSV infection, we generated recombinants of HSV-2(333) that expressed wild-type gD (HSV-2/gD) or mutant gD able to bind to nectin-1 (the other principal entry receptor) but not HVEM. Replication kinetics and yields of the recombinant strains on Vero cells were indistinguishable from those of wild-type HSV-2(333). After intravaginal inoculation with mutant or wild-type virus, adult female C57BL/6 mice developed vaginal lesions and mortality in similar proportions, and mucosal viral titers were similar or lower for mutant strains at different times. Relative to HSV-2/gD, percentages of HSV-specific CD8+ T-cells were similar or only slightly reduced after infection with the mutant strain HSV-2/gD-Δ7-15, in all tissues up to 9 days after infection. Levels of HSV-specific CD4+ T-cells five days after infection also did not differ after infection with either strain. Levels of the cytokine IL-6 and of the chemokines CXCL9, CXCL10, and CCL4 were significantly lower in vaginal washes one day after infection with HSV-2/gD compared with HSV-2/gD-Δ7-15. We conclude that the interaction of HSV gD with HVEM may alter early innate events in the murine immune response to infection, without significantly affecting acute mortality, morbidity, or initial T-cell responses after lethal challenge