The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus

Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression. New strategies are needed to slow the progression to end-stage kidney disease, which requires dialysis or transplantation. Thymosin β4 (Tβ4), an endogenous peptide that sequesters G-actin, has shown potent anti-inflammatory function in experimental models of heart, kidney, liver, lung, and eye injury. In this review, we discuss the role of endogenous and exogenous Tβ4 in glomerular disease progression and the current understanding of the underlying mechanisms

Integration of technologies for understanding the functional relationship between reef habitat and fish growth and production

Functional linkage between reef habitat quality and fish growth and production has remained elusive. Most current research is focused on correlative relationships between a general habitat type and presence/absence of a species, an index of species abundance, or species diversity. Such descriptive information largely ignores how reef attributes regulate reef fish abundance (density-dependent habitat selection), trophic interactions, and physiological performance (growth and condition). To determine the functional relationship between habitat quality, fish abundance, trophic interactions, and physiological performance, we are using an experimental reef system in the northeastern Gulf of Mexico where we apply advanced sensor and biochemical technologies. Our study site controls for reef attributes (size, cavity space, and reef mosaics) and focuses on the processes that regulate gag grouper (Mycteroperca microlepis) abundance, behavior and performance (growth and condition), and the availability of their pelagic prey. We combine mobile and fixed-active (fisheries) acoustics, passive acoustics, video cameras, and advanced biochemical techniques. Fisheries acoustics quantifies the abundance of pelagic prey fishes associated with the reefs and their behavior. Passive acoustics and video allow direct observation of gag and prey fish behavior and the acoustic environment, and provide a direct visual for the interpretation of fixed fisheries acoustics measurements. New application of biochemical techniques, such as Electron Transport System (ETS) assay, allow the in situ measurement of metabolic expenditure of gag and relates this back to reef attributes, gag behavior, and prey fish availability. Here, we provide an overview of our integrated technological approach for understanding and quantifying the functional relationship between reef habitat quality and one element of production – gag grouper growth on shallow coastal reefs

Defendant\u27s Brief in Opposition to Plaintiff\u27s Motion to Exclude Testimony from 1954 Coroner\u27s Inquest

The State of Ohio asserted that testimony from the 1954 coroner\u27s inquest should not be excluded because the coroner\u27s inquest was carried out properly under Ohio law. Sam Sheppard\u27s Fifth and Sixth Amendment rights would not be violated by admitting this evidence, nor would his right to due process. Additionally, coroner records are admissible as public records. See order ruling on this motion

Defendant\u27s Brief in Opposition to Plaintiff\u27s Motion to Exclude Testimony from 1954 Coroner\u27s Inquest

The State of Ohio asserted that testimony from the 1954 coroner\u27s inquest should not be excluded because the coroner\u27s inquest was carried out properly under Ohio law. Sam Sheppard\u27s Fifth and Sixth Amendment rights would not be violated by admitting this evidence, nor would his right to due process. Additionally, coroner records are admissible as public records. See order ruling on this motion

Methane hydrate formation in partially water-saturated Ottawa sand

This paper is not subject to U.S. copyright. The definitive version was published in American Mineralogist 89 (2004): 1202-1207.Bulk properties of gas hydrate-bearing sediment strongly depend on whether hydrate forms primarily in the pore fluid, becomes a load-bearing member of the sediment matrix, or cements sediment grains. Our compressional wave speed measurements through partially water-saturated, methane hydrate-bearing Ottawa sands suggest hydrate surrounds and cements sediment grains. The three Ottawa sand packs tested in the Gas Hydrate And Sediment Test Laboratory Instrument (GHASTLI) contain 38(1)% porosity, initially with distilled water saturating 58, 31, and 16% of that pore space, respectively. From the volume of methane gas produced during hydrate dissociation, we calculated the hydrate concentration in the pore space to be 70, 37, and 20% respectively. Based on these hydrate concentrations and our measured compressional wave speeds, we used a rock physics model to differentiate between potential pore-space hydrate distributions. Model results suggest methane hydrate cements unconsolidated sediment when forming in systems containing an abundant gas phase.This work was supported by the U.S. Geological Surveyʼs Coastal and Marine Geology and Eastern Region Gas Hydrate Programs, in addition to DOE contract DE-AI21-92MC29214

Development of Bone Targeting Drugs.

The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+). The strategies for designing such targeting moieties can involve synthetic and/or biological components including negatively-charged amino acid peptides or bisphosphonates. Efficient delivery of bone-specific drugs provides significant impact in the treatment of skeletal related disorders including infectious diseases (osteoarthritis, osteomyelitis, etc.), osteoporosis, and metabolic skeletal dysplasia. Despite recent advances, however, both delivering the drug to its target without losing activity and avoiding adverse local effects remain a challenge. In this review, we investigate the current development of bone-targeting moieties, their efficacy and limitations, and discuss future directions for the development of these specific targeted treatments

Mountains of Maize, Persistent Poverty

The past two years are a tribute to Zambian farmers; they have responded admirably to government efforts to promote maize production. But ironically, rural poverty remains stubbornly high despite the fact that the government has spent over 2% of the nation’s gross domestic product in supporting maize production and subsidizing inputs for farmers. Why is it that maize production has increased so impressively without making a serious dent in rural poverty? And what are the lessons for the new government?maize, poverty, Zambia, Agricultural and Food Policy, Food Security and Poverty,

The discovery of 2.78 hour periodic modulation of the X-ray flux from globular cluster source Bo 158 in M31

We report the discovery of periodic intensity dips in the X-ray source XMMU J004314.1+410724, in the globular cluster Bo158 in M31. The X-ray flux was modulated by ~83% at a period of 2.78 hr (10017 s) in an XMM-Newton observation taken 2002 Jan 6-7. The X-ray intensity dips show no energy dependence. We detected weaker dips with the same period in observations taken 2000 June 25 (XMM-Newton) and 1991 June 26 (ROSAT/PSPC). The amplitude of the modulation has been found to be anticorrelated with source X-ray flux: it becomes lower when the source intensity rises. The energy spectrum of Bo158 was stable from observation to observation, with a characteristic cutoff at ~4-6 keV. The photo-electric absorption was consistent with the Galactic foreground value. No significant spectral changes were seen in the course of the dips. If the 2.78 hr cycle is the binary period of Bo158 the system is highly compact, with a binary separation of ~10e11 cm. The association of the source with a globular cluster, together with spectral parameters consistent with Galactic neutron star sources, suggests that X-rays are emitted by an accreting neutron star. The properties of Bo 158 are somewhat reminiscent of the Galactic X-ray sources exhibiting a dip-like modulations. We discuss two possible mechanisms explaining the energy-independent modulation observed in Bo 158: i) the obscuration of the central source by highly ionized material that scatters X-rays out of the line of sight; ii) partial covering of an extended source by an opaque absorber which occults varying fractions of the source.Comment: 10 pages, 4 figures, ApJ, submitted, uses emulateapj styl

Infrastructure expansion and the Indonesian Borneo tropical forests

Indonesian Borneo (Kalimantan) houses ~41 million hectares of tropical forest with global environmental significance. Currently, numerous infrastructure expansion projects are occurring in the region aiming to boost economic growth. We spatially analyzed the potential impacts of this infrastructure expansion on tropical forests and agro-economic development in the region. We found that many routes will entail numerous detrimental ecological impacts, including limiting faunal movement, reducing habitat connectivity, creating isolated forest patches, fragmenting current intact forests, substantially increasing forest edge effects, and reducing core forests habitat area. Furthermore, several routes will dissect a number of current protected areas, potentially undermining Indonesian efforts to achieve the Aichi target 11 of the Convention on Biological Diversity (CBD) i.e. 17% terrestrial protected area connectivity by 2020. These infrastructure expansions are likely to facilitate the further development of extractive industries, namely, mining, logging, and oil palm estate agriculture but they are highly unlikely to generate the envisioned agro-economic development. Our study suggests that the current increasing trend of infrastructure expansion- ignoring the environmental values at the core of the approach- sharply increases the likelihood of serious ecosystem decay in the tropical forests of Indonesian Borneo