3,792 research outputs found
Intramedullary Spine Disease
One of the most significant impacts of magnetic resonance (MRI) has been its ability to exquisitely depict normal and pathologic anatomy of the spine. This unit presents a that deals with intramedullary disease, i.e., that involving the cord. An is presented for cases of extramedullary‐intradural disease.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145323/1/cpmia0901.pd
Data Compression Techniques for Advanced Space Transportation Systems
Advanced space transportation systems, including vehicle state of health systems, will produce large amounts of data which must be stored on board the vehicle and or transmitted to the ground and stored. The cost of storage or transmission of the data could be reduced if the number of bits required to represent the data is reduced by the use of data compression techniques. Most of the work done in this study was rather generic and could apply to many data compression systems, but the first application area to be considered was launch vehicle state of health telemetry systems. Both lossless and lossy compression techniques were considered in this study
Shear Bond Strength Comparison between Two Orthodontic Adhesives and Self-Ligating and Conventional Brackets
Objective: To evaluate and compare the shear bond strengths of two adhesives using two types of brackets: a conventional and a self-ligating bracket system.
Materials and Methods: Sixty extracted human premolars were collected. The premolars were randomly divided into three groups of 20 teeth. All three groups were direct bonded. Groups 1 and 2 used light-cured adhesive and primer (Transbond XT) with a conventional (Orthos) and a self-ligating bracket (Damon 2), respectively. Group 3 used a light-cured primer (Orthosolo) and a light-cured adhesive (Blūgloo) with a self-ligating bracket (Damon 2). The specimens were stored in distilled water at 37°C for 40 ± 2 hours, after which they were debonded and inspected for Adhesive Remnant Index (ARI) scoring.
Results: The mean shear bond strength was 15.2 MPa for group 1, 23.2 MPa for group 2, and 24.8 MPa for group 3. A one-way analysis of variance and post hoc Tukey test showed significant differences in bond strength (P \u3c .001) between group 1 and groups 2 and 3 but no significant difference (P \u3e .05) between groups 2 and 3. A Weibull analysis demonstrated that all three groups provided sufficient bond strength with over 90% survival rate at normal masticatory and orthodontic force levels. A Kruskal-Wallis test showed no significant difference (P \u3e .05) in ARI scores among all three groups.
Conclusions: All three groups demonstrated clinically acceptable bond strength. The Damon 2 self-ligating bracket exhibited satisfactory in vitro bond strength with both adhesive systems used
Reweighted LP decoding for LDPC codes
We introduce a novel algorithm for decoding binary linear codes by linear programming. We build on the LP decoding algorithm of Feldman et al. and introduce a post-processing step that solves a second linear program that reweights the objective function based on the outcome of the original LP decoder output. Our analysis shows that for some LDPC ensembles we can improve the provable threshold guarantees compared to standard LP decoding. We also show significant empirical performance gains for the reweighted LP decoding algorithm with very small additional computational complexity
Globular Cluster Systems in Brightest Cluster Galaxies: Bimodal Metallicity Distributions and the Nature of the High-Luminosity Clusters
We present new (B,I) photometry for the globular cluster systems in eight
Brightest Cluster Galaxies (BCGs), obtained with the ACS/WFC camera on the
Hubble Space Telescope. In the very rich cluster systems that reside within
these giant galaxies, we find that all have strongly bimodal color
distributions All the BCGs show population gradients, with much higher relative
numbers of red clusters within 5 kpc of their centers, consistent with their
having formed at later times than the blue, metal-poor population. A striking
new feature of the color distributions emerging from our data is that for the
brightest clusters (M_I < -10.5) the color distribution becomes broad and less
obviously bimodal. we suggest that it may be a characteristic of many BCGs.
Furthermore, the blue (metal-poor) clusters become progressively redder with
increasing luminosity, following a mass/metallicity scaling relation Z ~
M^0.55. We argue that these GCS characteristics are consistent with a
hierarchical-merging formation picture in which the metal-poor clusters formed
in protogalactic clouds or dense starburst complexes with gas masses in the
range 10^7 - 10^10 M_Sun, but where the more massive clusters on average formed
in bigger clouds with deeper potential wells where more pre-enrichment could
occur.Comment: 48 pages, 24 Figures, PDF, Submitted to Astrophys.J. and refereed.
For complete pdf file with better figures, see:
http://physwww.mcmaster.ca/%7Eharris/Preprints.htm
Reweighted LP Decoding for LDPC Codes
We introduce a novel algorithm for decoding binary linear codes by linear programming (LP). We build on the LP decoding algorithm of Feldman and introduce a postprocessing step that solves a second linear program that reweights the objective function based on the outcome of the original LP decoder output. Our analysis shows that for some LDPC ensembles we can improve the provable threshold guarantees compared to standard LP decoding. We also show significant empirical performance gains for the reweighted LP decoding algorithm with very small additional computational complexity
Distributed computation of transient state distributions and passage time quantiles in large semi-Markov models
Submitted versio
Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles
Over 95% of pancreatic adenocarcinomas (PDACs), as well as a large fraction of other tumor types, such as colorectal adenocarcinoma, are driven by KRAS activation. However, no direct RAS inhibitors exist for cancer therapy. Furthermore, the delivery of therapeutic agents of any kind to PDAC in particular has been hindered by the extensive desmoplasia and resultant drug delivery challenges that accompanies these tumors. Small interfering RNA (siRNA) is a promising modality for anti-neoplastic therapy due to its precision and wide range of potential therapeutic targets. Unfortunately, siRNA therapy is limited by low serum half-life, vulnerability to intracellular digestion, and transient therapeutic effect. We assessed the ability of a peptide based, oligonucleotide condensing, endosomolytic nanoparticle (NP) system to deliver siRNA to KRAS-driven cancers. We show that this peptide-based NP is avidly taken up by cancer cell
The Globular Cluster Systems around NGC 3311 and NGC 3309
We present extensive new photometry in (g',i') of the large globular cluster
(GC) system around NGC 3311, the central cD galaxy in the Hydra cluster. Our
GMOS data cover a 5.5' field of view and reach a limiting magnitude i' = 26,
about 0.5 magnitude fainter than the turnover point of the GC luminosity
function. We find that NGC 3311 has a huge population of ~16, 000 GCs, closely
similar to the prototypical high specific frequency Virgo giant M87. The
color-magnitude distribution shows that the metal-poor blue GC sequence and the
metal-richer red sequence are both present, with nearly equal numbers of
clusters. Bimodal fits to the color distributions confirm that the blue
sequence shows the same trend of progressively increasing metallicity with GC
mass that has previously been found in many other large galaxies; the
correlation we find corresponds to a scaling of GC metallicity with mass of Z ~
M^0.6 . By contrast, the red sequence shows no change of mean metallicity with
mass, but it shows an upward extension to much higher than normal luminosity
into the UCD-like range, strengthening the potential connections between
massive GCs and UCDs. The GC luminosity function, which we measure down to the
turnover point at M_I = -8.4, also has a normal form like those in other giant
ellipticals. Within the Hydra field, another giant elliptical NGC 3309 is
sitting just 100" from the cD NGC 3311. We use our data to solve simultaneously
for the spatial structure and total GC populations of both galaxies at once.
Their specific frequencies are S_N (NGC 3311) = 12.5 +/- 1.5 and S_N (NGC 3309)
= 0.6 +/-0.4. NGC 3311 is completely dominant and entirely comparable with
other cD-type systems such as M87 in Virgo.Comment: 15 pages, 15 figures. Accepted to the Astrophysical Journal. Version
with higher resolution figures is available at
http://www.thewehners.net/astro/papers/wehner_n3311_highres.pd
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