3,490 research outputs found
DECOMPOSING THE SIZE EFFECT ON THE ADOPTION OF INNOVATIONS: AGROBIOTECHNOLOGY AND PRECISION FARMING
This study contrasts the relationship between farm-size and adoption for two types of innovations, genetically engineered crops and precision farming, controlling for other factors. The analysis uses an extension of the McDonald and Moffit decomposition for the two-limit Tobit model.Research and Development/Tech Change/Emerging Technologies,
Towards the Synthesis of Write-Ahead Logging
The implications of robust models have been far-reaching and pervasive. In this paper, authors validate the synthesis of local-area networks. In our research, we present an algorithm for interposable algorithms (OrbicWem), validating that the famous semantic algorithm for the visualization of sensor net- works by Wu and Wang is optimal
Identification of Disulfide Bond Formation between MitoNEET and Glutamate Dehydrogenase 1
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1
Identification of Disulfide Bond Formation between MitoNEET and Glutamate Dehydrogenase 1
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1
A Report of Florida’s Cancer History, Risk Factors, and Screening Behaviors: Data from the National Health Interview Survey
To target populations at greatest risk ofdeveloping cancer, it is vital to understand the patterns ofrisk factors and screening behaviors along with cancer surveillance data. This study provides data on the prevalence of self-reported cancer history, can- cer risk factors, and cancer screening behaviors in Florida and compares them to rates in the rest ofthe U.S. Data were ob- tained from the National Health Interview Survey (NHIS), an annual, cross-sectional household survey of the U.S. civilian non-institutionalized population. We analyzed pooled data from the 2000 and 2005 Cancer Control Modules. Compared to the rest ofthe U.S., Floridians reported a lower prevalence ofcurrent smoking, risky drinking, and obesity, and a greater pre- valence ofProstate Specific Antigen (PSA) testing. However, Floridians reported a greater prevalence ofcancer history and a lower prevalence of physical activity, concern for sun protection, lifetime colorectal cancer screening, lifetime breast exam, life- time mammography screening, and lifetime and past year Pap test. The data indicate that Florida lags behind the rest of the U.S. in several areas, particularly cancer screening, and falls short ofthe Healthy People 2020 objectives for health behaviors and screening. These results provide information for key stakeholders and public health policy makers to effectively target Flor- ida residents at greatest risk for cancer and those not receiving recommended cancer screenings. This study also represents a model ofvaluable state-level evaluations that can be conducted using NHIS data. These types ofanalyses can provide a great- er understanding of state-level variations and lead to more effective public health interventions aimed at reducing cancer bur- den
Spitzer observations of HH54 and HH7-11: mapping the H2 ortho-to-para ratio in shocked molecular gas
We report the results of spectroscopic mapping observations carried out
toward the Herbig-Haro objects HH7-11 and HH54 over the 5.2 - 37 micron region
using the Infrared Spectrograph of the Spitzer Space Telescope. These
observations have led to the detection and mapping of the S(0) - S(7) pure
rotational lines of molecular hydrogen, together with emissions in fine
structure transitions of Ne+, Si+, S, and Fe+. The H2 rotational emissions
indicate the presence of warm gas with a mixture of temperatures in the range
400 - 1200 K, consistent with the expected temperature behind nondissociative
shocks of velocity ~ 10 - 20 km/s, while the fine structure emissions originate
in faster shocks of velocity 35 - 90 km/s that are dissociative and ionizing.
Maps of the H2 line ratios reveal little spatial variation in the typical
admixture of gas temperatures in the mapped regions, but show that the H2
ortho-to-para ratio is quite variable, typically falling substantially below
the equilibrium value of 3 attained at the measured gas temperatures. The
non-equilibrium ortho-to-para ratios are characteristic of temperatures as low
as ~ 50 K, and are a remnant of an earlier epoch, before the gas temperature
was elevated by the passage of a shock. Correlations between the gas
temperature and H2 ortho-to-para ratio show that ortho-to-para ratios < 0.8 are
attained only at gas temperatures below ~ 900 K; this behavior is consistent
with theoretical models in which the conversion of para- to ortho-H2 behind the
shock is driven by reactive collisions with atomic hydrogen, a process which
possesses a substantial activation energy barrier (E_A/k ~ 4000 K) and is
therefore very inefficient at low temperature.Comment: 45 pages, including 16 figures. Accepted for publication in Ap
The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease
APOE4 is the greatest genetic risk factor for late-onset Alzheimer’s disease (AD), increasing the risk of developing the disease by 3-fold in the 14% of the population that are carriers. Despite 25 years of research, the exact mechanisms underlying how APOE4 contributes to AD pathogenesis remain incompletely defined. APOE in the brain is primarily expressed by astrocytes and microglia, cell types that are now widely appreciated to play key roles in the pathogenesis of AD; thus, a picture is emerging wherein APOE4 disrupts normal glial cell biology, intersecting with changes that occur during normal aging to ultimately cause neurodegeneration and cognitive dysfunction. This review article will summarize how APOE4 alters specific pathways in astrocytes and microglia in the context of AD and the aging brain. APOE itself, as a secreted lipoprotein without enzymatic activity, may prove challenging to directly target therapeutically in the classical sense. Therefore, a deeper understanding of the underlying pathways responsible for APOE4 toxicity is needed so that more tractable pathways and drug targets can be identified to reduce APOE4-mediated disease risk
Deep Underground Science and Engineering Laboratory - Preliminary Design Report
The DUSEL Project has produced the Preliminary Design of the Deep Underground
Science and Engineering Laboratory (DUSEL) at the rehabilitated former
Homestake mine in South Dakota. The Facility design calls for, on the surface,
two new buildings - one a visitor and education center, the other an experiment
assembly hall - and multiple repurposed existing buildings. To support
underground research activities, the design includes two laboratory modules and
additional spaces at a level 4,850 feet underground for physics, biology,
engineering, and Earth science experiments. On the same level, the design
includes a Department of Energy-shepherded Large Cavity supporting the Long
Baseline Neutrino Experiment. At the 7,400-feet level, the design incorporates
one laboratory module and additional spaces for physics and Earth science
efforts. With input from some 25 science and engineering collaborations, the
Project has designed critical experimental space and infrastructure needs,
including space for a suite of multidisciplinary experiments in a laboratory
whose projected life span is at least 30 years. From these experiments, a
critical suite of experiments is outlined, whose construction will be funded
along with the facility. The Facility design permits expansion and evolution,
as may be driven by future science requirements, and enables participation by
other agencies. The design leverages South Dakota's substantial investment in
facility infrastructure, risk retirement, and operation of its Sanford
Laboratory at Homestake. The Project is planning education and outreach
programs, and has initiated efforts to establish regional partnerships with
underserved populations - regional American Indian and rural populations
Muon Spin Relaxation Study of (La, Ca)MnO3
We report predominantly zero field muon spin relaxation measurements in a
series of Ca-doped LaMnO_3 compounds which includes the colossal
magnetoresistive manganites. Our principal result is a systematic study of the
spin-lattice relaxation rates 1/T_1 and magnetic order parameters in the series
La_{1-x}Ca_xMnO_3, x = 0.0, 0.06, 0.18, 0.33, 0.67 and 1.0. In LaMnO_3 and
CaMnO_3 we find very narrow critical regions near the Neel temperatures T_N and
temperature independent 1/T_1 values above T_N. From the 1/T_1 in LaMnO_3 we
derive an exchange integral J = 0.83 meV which is consistent with the mean
field expression for T_N. All of the doped manganites except CaMnO_3 display
anomalously slow, spatially inhomogeneous spin-lattice relaxation below their
ordering temperatures. In the ferromagnetic (FM) insulating
La_{0.82}Ca_{0.18}MnO_3 and ferromagnetic conducting La_{0.67}Ca_{0.33}MnO_3
systems we show that there exists a bi-modal distribution of \muSR rates
\lambda_f and \lambda_s associated with relatively 'fast' and 'slow' Mn
fluctuation rates, respectively. A physical picture is hypothesized for these
FM phases in which the fast Mn rates are due to overdamped spin waves
characteristic of a disordered FM, and the slower Mn relaxation rates derive
from distinct, relatively insulating regions in the sample. Finally, likely
muon sites are identified, and evidence for muon diffusion in these materials
is discussed.Comment: 21 pages, 17 figure
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