435 research outputs found
Father Andrew Mullen 1790-1818: a study in early nineteenth century spirituality
This thesis is laid out in three parts: Part I. The life and death of Andrew Mullen. The life is based, to a large extent, on a long letter to his mother, Catherine Mullen, dated 7 January 1810. The letter gives a definite insight into his spirituality based on his membership of the Archconfraternity of the Blessed Sacrament. There is a hint that he had a premonition of an early death. Part II. The burial of Andrew Mullen and the immediate cult to him This is based on documentary evidence. Part III. Most of this part is a catalogue of testimonies taken from 1993 onwards. Then there is the conclusion on the popular devotion to Andrew Mullen stressing the theological aspect of the subject. In the course of writing the thesis it was decided to separate the documentary evidence from the oral tradition. This was advantageous in developing the thesis, and the documents provided a secure basis for the oral tradition. Two pieces of information were found in March 1997. They are death notices: 2 January 1819, The Leinster Journal and 7 January 1819, The Car low Morning Post. There is a slight discrepancy between the two on the date of his death. Also this discrepancy shows a slight difference from the date of the tombstone
Probabilistic sensitivity analysis of biochemical reaction systems
Sensitivity analysis is an indispensable tool for studying the robustness and fragility properties of biochemical reaction systems as well as for designing optimal approaches for selective perturbation and intervention. Deterministic sensitivity analysis techniques, using derivatives of the system response, have been extensively used in the literature. However, these techniques suffer from several drawbacks, which must be carefully considered before using them in problems of systems biology. We develop here a probabilistic approach to sensitivity analysis of biochemical reaction systems. The proposed technique employs a biophysically derived model for parameter fluctuations and, by using a recently suggested variance-based approach to sensitivity analysis [Saltelli et al., Chem. Rev. (Washington, D.C.) 105, 2811 (2005)], it leads to a powerful sensitivity analysis methodology for biochemical reaction systems. The approach presented in this paper addresses many problems associated with derivative-based sensitivity analysis techniques. Most importantly, it produces thermodynamically consistent sensitivity analysis results, can easily accommodate appreciable parameter variations, and allows for systematic investigation of high-order interaction effects. By employing a computational model of the mitogen-activated protein kinase signaling cascade, we demonstrate that our approach is well suited for sensitivity analysis of biochemical reaction systems and can produce a wealth of information about the sensitivity properties of such systems. The price to be paid, however, is a substantial increase in computational complexity over derivative-based techniques, which must be effectively addressed in order to make the proposed approach to sensitivity analysis more practical
Alien Registration- Dempsey, William C. (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/24623/thumbnail.jp
Intercellular Bridges in Vertebrate Gastrulation
The developing zebrafish embryo has been the subject of many studies of regional patterning, stereotypical cell movements and changes in cell shape. To better study the morphological features of cells during gastrulation, we generated mosaic embryos expressing membrane attached Dendra2 to highlight cellular boundaries. We find that intercellular bridges join a significant fraction of epiblast cells in the zebrafish embryo, reaching several cell diameters in length and spanning across different regions of the developing embryos. These intercellular bridges are distinct from the cellular protrusions previously reported as extending from hypoblast cells (1–2 cellular diameters in length) or epiblast cells (which were shorter). Most of the intercellular bridges were formed at pre-gastrula stages by the daughters of a dividing cell maintaining a membrane tether as they move apart after mitosis. These intercellular bridges persist during gastrulation and can mediate the transfer of proteins between distant cells. These findings reveal a surprising feature of the cellular landscape in zebrafish embryos and open new possibilities for cell-cell communication during gastrulation, with implications for modeling, cellular mechanics, and morphogenetic signaling
An analysis of the dates found in six sixth grade old world history textbooks.
Thesis (Ed.M.)--Boston Universit
Factors affecting mortality in late stage Parkinson’s Disease
To determine the effect of dysphagia and hospital admissions on mortality in late stage Parkinson’s disease
Bankruptcy Reform: An Orderly Development of Public Policy
In legislating the pending bankruptcy reform, Congress has made many of the key decisions behind closed doors. In fact, the process has been characterized as a congressional effort to pass a stealth bankruptcy bill. This secrecy brings into question the democratic nature of congressional deliberation. When the Framers designed the legislative branch, open debate was envisioned as the rule, not the exception. Unfortunately, Congress has adopted a secretive, approach to pushing through recent bankruptcy legislation. In a sharp departure from the decades-long congressional approach to bankruptcy legislation, Congress stopped seeking expert advice and instead turned to special interest lobbyists…” Thus, Congress utilized the cover of secrecy to boldly tailor the bankruptcy laws to serve special interests. Consequently, theuse of the term \u27bankruptcy reform\u27 is considered an oxymoron to most organizations of bankruptcy professionals .... Virtually every group of bankruptcy professionals, regardless of the constituency represented, opposed both the substance of the legislation and the process ... taken by Congress. Recent efforts to alter the bankruptcy system under the cover of secrecy have received harsh criticism. Proponents of bankruptcy reform are so intent upon enacting legislation favoring special interests that they have taken the unprecedented step of attempting to enact the legislation under the guise of a completely unrelated, already-enacted bill. These tactics of congressional secrecy are contrary to the process of open, reasoned, and deliberate decision making that is a cornerstone of American democracy. This secrecy is wholly inconsistent with the process of public deliberation which the Founders envisioned
Bankruptcy Reform: An Orderly Development of Public Policy
In legislating the pending bankruptcy reform, Congress has made many of the key decisions behind closed doors. In fact, the process has been characterized as a congressional effort to pass a stealth bankruptcy bill. This secrecy brings into question the democratic nature of congressional deliberation. When the Framers designed the legislative branch, open debate was envisioned as the rule, not the exception. Unfortunately, Congress has adopted a secretive, approach to pushing through recent bankruptcy legislation. In a sharp departure from the decades-long congressional approach to bankruptcy legislation, Congress stopped seeking expert advice and instead turned to special interest lobbyists…” Thus, Congress utilized the cover of secrecy to boldly tailor the bankruptcy laws to serve special interests. Consequently, theuse of the term \u27bankruptcy reform\u27 is considered an oxymoron to most organizations of bankruptcy professionals .... Virtually every group of bankruptcy professionals, regardless of the constituency represented, opposed both the substance of the legislation and the process ... taken by Congress. Recent efforts to alter the bankruptcy system under the cover of secrecy have received harsh criticism. Proponents of bankruptcy reform are so intent upon enacting legislation favoring special interests that they have taken the unprecedented step of attempting to enact the legislation under the guise of a completely unrelated, already-enacted bill. These tactics of congressional secrecy are contrary to the process of open, reasoned, and deliberate decision making that is a cornerstone of American democracy. This secrecy is wholly inconsistent with the process of public deliberation which the Founders envisioned
MS 004 Guide to William D. Seybold, MD Papers, 1890-1983
The papers of Dr. Seybold are made up primarily of office files, correspondence and memoranda, newsclippings, articles, committee meeting minutes and reports; the working files of a prominent Houston physician who at one time or another served as chief of staff at St. Luke\u27s Episcopal Hospital, partner and chief of staff of the KelseySeybold Clinic, president of the Texas Surgical Society, member of the University of Texas Committee of 75 and the Centennial Commission. They document his career from late in his surgical residency to his retirement from private practice in 1979.
See more at https://archives.library.tmc.edu/ms-00
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