Children\u27s cognitive processing of abuse as described in investigative interviews.

A great deal of research has examined ways in which investigative interviewers can elicit accurate information from children. More recently, research has studied children’s own thoughts or comprehension of abuse, and how these types of statements relate to disclosure, others’ perceptions of child witnesses, and psychological trauma. However, little research has investigated multiple types of children’s thoughts about abuse as they occur in an actual investigative interview. The current study examined seven types of statements children made about their abuse in a sample of 86 transcripts of investigative interviews conducted by Child Protective Services and a police department in a mid-sized Ontario city. Children interviewed ranged from 4- to 17-years-of-age, with approximately equal numbers of males and females. Type of abuse disclosed in the interviews ranged from verbal abuse to sexual abuse. Two coders independently coded each transcript for seven statement types: expected consequences of disclosure, actual consequences of disclosure, minimization, justification for either self, perpetrator, or other, and blame. Whether the statements were elicited by an interviewer prompt or mentioned spontaneously by the child was also coded. Results demonstrated that children blamed the perpetrator more than any other statement type, consistent with previous research. Analyses also revealed a significant relationship between abuse type and children’s statements, and alleged perpetrator and children’s statements. Results from the current study have implications for disclosure, treatment of psychological trauma, and how parents, social workers, police officers, attorneys, and judges view children’s statements

Children\u27s cognitive processing of abuse as described in investigative interviews.

A great deal of research has examined ways in which investigative interviewers can elicit accurate information from children. More recently, research has studied children’s own thoughts or comprehension of abuse, and how these types of statements relate to disclosure, others’ perceptions of child witnesses, and psychological trauma. However, little research has investigated multiple types of children’s thoughts about abuse as they occur in an actual investigative interview. The current study examined seven types of statements children made about their abuse in a sample of 86 transcripts of investigative interviews conducted by Child Protective Services and a police department in a mid-sized Ontario city. Children interviewed ranged from 4- to 17-years-of-age, with approximately equal numbers of males and females. Type of abuse disclosed in the interviews ranged from verbal abuse to sexual abuse. Two coders independently coded each transcript for seven statement types: expected consequences of disclosure, actual consequences of disclosure, minimization, justification for either self, perpetrator, or other, and blame. Whether the statements were elicited by an interviewer prompt or mentioned spontaneously by the child was also coded. Results demonstrated that children blamed the perpetrator more than any other statement type, consistent with previous research. Analyses also revealed a significant relationship between abuse type and children’s statements, and alleged perpetrator and children’s statements. Results from the current study have implications for disclosure, treatment of psychological trauma, and how parents, social workers, police officers, attorneys, and judges view children’s statements

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.N

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Funder: Kjell och Märta Beijers StiftelseAlthough physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention