2 research outputs found

    Effect of piroxicam on lipid membranes : Drug encapsulation and gastric toxicity aspects

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    Uptake of piroxicam, a non-steroidal anti-inflammatory drug, from the intestines after oral intake is limited due to its low solubility and its wide use is associated with several side effects related to the gastrointestinal tract. In this study, all-atom molecular dynamics (MD) simulations and fluorescent spectroscopy were employed to investigate the interaction of piroxicam in neutral, zwitterionic, and cationic forms with lipid bilayers composed of phosphatidylcholine, cholesterol, and PEGylated lipids. Our study was aimed to assess the potential for encapsulation of piroxicam in liposomal carriers and to shed more light on the process of gastrointestinal tract injury by the drug. Through both the MD simulations and laser scanning confocal microscopy, we have demonstrated that all forms of piroxicam can associate with the lipid bilayers and locate close to the water-membrane interface. Conventional liposomes used in drug delivery are usually stabilized by the addition of cholesterol and have their bloodstream lifetime extended through the inclusion of PEGylated lipids in the formulation to create a protective polymer corona. For this reason, we tested the effect of these two modifications on the behavior of piroxicam in the membrane. When the bilayer was PEGylated, piroxicam localize to the PEG layer and within the lipid headgroup region. This suggests that PEGylated liposomes are capable of carrying a larger quantity of piroxicam than the conventional ones. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe

    Le village celtique des arènes à Levroux. Description des structures - Levroux 2

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    Dans Levroux 1 étaient présentées la prospection sur le canton de Levroux et les fouilles sur l'oppidum de la Colline des Tours. Levroux 2 est consacré à la fouille du village celtique des Arènes. Les plans, les coupes et la description des structures archéologiques sont réunis dans ce volume. Pour chaque fosse est également donné un inventaire du mobilier. Dans le volume suivant seront présentés les dessins et l'inventaire du mobilier remarquable. Enfin l'analyse de toutes ces découvertes trouvera sa place dans Levroux 4.Buchsenschutz Olivier, Colin Anne, Krausz Sophie et al. Le village celtique des arènes à Levroux. Description des structures - Levroux 2. Tours : Fédération pour l'édition de la Revue archéologique du Centre de la France, 1993. 224 p. (Supplément à la Revue archéologique du centre de la France, 8
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