Postpartum depression – researching new methods for diagnosis, education, and treatment

Postpartum depression can affect, directly or indirectly, both mothers and fathers after the birth of a child. The primary goal of the project was to conduct exploratory research to determine new methods for diagnosis and treatment of the condition. Specifically, we looked for ways to use technology to educate people about postpartum depression, as well as treat it. We hoped this would also increase accessibility of care to all communities. We conducted interviews directly with people who had experienced postpartum depression as well as people who knew someone who experienced it. Through the interviews we learned about their experiences and asked when and where intervention could have helped alleviate the condition. We also polled them about using technology to treat postpartum depression, and whether they found that to be potentially helpful. After completing the interviews, we collected our data and prepared a report containing our findings and recommendations.Informatio

Modeling Early Archaic Mobility and Subsistence: Evaluating Resource Risk Across The South Carolina Landscape

Previous models predicting Early Archaic mobility and subsistence strategies in South Carolina have evaluated behavioral negotiations of specific resource distributions. A new model is presented using empirical datasets that quantify and evaluate the quality and geographic distributions of lithic raw materials and drainage systems in the state. By utilizing datasets from private collections and landscape elevation data, this model is generated using Geographic Information Systems (GIS) software in order to produce a Risk Landscape from which predictions of site density, artifact density, lithic raw material diversity, and the condition of lithic toolkit assemblages can be generated based on landscape location. This model is tested using geographically extensive private collections from site specific locations and demonstrate variability in archaeological assemblages based on proximity to resources

1919, Postcard

https://digitalcommons.chapman.edu/jbwilkinson_collection/1002/thumbnail.jp

1919-01-03, Postcard

https://digitalcommons.chapman.edu/jbwilkinson_collection/1000/thumbnail.jp

1919, Postcard

https://digitalcommons.chapman.edu/jbwilkinson_collection/1001/thumbnail.jp

Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

Alzheimer's disease (AD) is increasing in prevalence with the aging population. Deposition of amyloid-β (Aβ) in the brain of AD patients is a hallmark of the disease and is associated with increased microglial numbers and activation state. The interaction of microglia with Aβ appears to play a dichotomous role in AD pathogenesis. On one hand, microglia can phagocytose and clear Aβ, but binding of microglia to Aβ also increases their ability to produce inflammatory cytokines, chemokines, and neurotoxic reactive oxygen species (ROS). Scavenger receptors, a group of evolutionally conserved proteins expressed on the surface of microglia act as receptors for Aβ. Of particular interest are SCARA-1 (scavenger receptor A-1), CD36, and RAGE (receptor for advanced glycation end products). SCARA-1 appears to be involved in the clearance of Aβ, while CD36 and RAGE are involved in activation of microglia by Aβ. In this review, we discuss the roles of various scavenger receptors in the interaction of microglia with Aβ and propose that these receptors play complementary, nonredundant functions in the development of AD pathology. We also discuss potential therapeutic applications for these receptors in AD