The development of Dicken's treatment of high society, with special reference to the period 1833-1852

This thesis is divided into two parts, each covering roughly a decade and concentrating on a major phase in the development of Dickens's treatment of High Society. A general introduction gives reasons for reassessing this development and indicates the lines of argument to be followed with an explanation of the terminology involved. Part One, Chapter I, discusses the background to Dickens's treatment of High Society in the period up to Barnaby. It pays special attention to historical and literary influences and compares prevailing attitudes to High Society with Dickens's own. Chapter 2 is a detailed study of the parts Cordon and Chester play in Barnaby. It highlights the importance of Gordon in Dickens's treatment of High Society and sees Barnaby as the culmination of one phase of its development. A general introduction to Part Two emphasised that the eighteen-forties was a decade of change and stresses the problems of discussing such a decade. Chapter 1 is a further background chapter, following the same lines as Part One, Chapter 1. It shows Dickens increasingly discriminating between High Society as an institution and individual members of it. Three Chapters on individual novels shows Dickens's progress towards an overall view3of Society and his maturing ability to understand and portray the upper classes. In the Chapter on Bleak House Dicken's treatment of High Society is seen to have matured and the portraits of Sir Leicester and Lady Dedlock are discussed as the culmination of development traced through preceding chapters. Chanter 5 is a brief survey of the period after 1852 and suggests that when further development there is merely a refinement of attitudes and techniques apparent in Bleak House. A brief conclusion sums up the argument of the thesis as a whole.<p

The synovial proteome: analysis of fibroblast-like synoviocytes

The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ionization mass spectrometry. A total of 368 spots were examined and 254 identifications were made. The studies identified a number of proteins that have been implicated in the normal or pathological FLS function (e.g. uridine diphosphoglucose dehydrogenase, galectin 1 and galectin 3) or that have been characterized as potential autoantigens in rheumatoid arthritis (e.g. BiP, colligin, HC gp-39). A novel uncharacterized protein product of chromosome 19 open reading frame 10 was also detected as an apparently major component of FLS cells. These results demonstrate the utility of high-content proteomic approaches in the analysis of FLS composition

Appreciating Feral Hogs: Extension Education for Diverse Stakeholders in Texas

Texas harbors the largest population of feral hogs (Sus scrofa) in the United States, with populations estimated at \u3e2 million. Depending on one’s perspective, feral hogs are either a pariah (from the farmer’s standpoint) or a popular sporting animal (from a hunter’s standpoint). As feral hogs increase in range and density, conflicts among stakeholders are sure to increase. Texas Cooperative Extension (TCE) initiated educational programs in 1991 to address concerns regarding the presence and management of feral hogs. Since that time, we have developed various workshops, symposia, and educational materials (e.g., print, videotape, and website) as means of addressing “the good, the bad, and the ugly” aspects of feral hogs in Texas. Texas Cooperative Extension involves various stakeholder groups, including agriculturalists, biologists, hunters, and wildlife damage management professionals in its efforts to provide a thorough, balanced approach to management of feral hogs. Our goal is to increase critical thinking skills among stakeholders while seeking consensus on local damage issues caused by feral hogs

PtdIns(4,5)P2 Functions at the Cleavage Furrow during Cytokinesis

SummaryPhosphoinositides play important roles in regulating the cytoskeleton and vesicle trafficking, potentially important processes at the cleavage furrow. However, it remains unclear which, if any, of the phosphoinositides play a role during cytokinesis. A systematic analysis to determine if any of the phosphoinositides might be present or of functional importance at the cleavage furrow has not been published. Several studies hint at a possible role for one or more phosphoinositides at the cleavage furrow. The best of these are genetic data identifying mutations in phosphoinositide-modifying enzymes (a PtdIns(4)P-5-kinase in S. pombe [1, 2] and a PI-4-kinase in D. melanogaster [3]) that interfere with cytokinesis. The genetic nature of these experiments leaves questions as to how direct may be their contribution to cytokinesis. Here we show that a single phosphoinositide, PtdIns(4,5)P2, specifically accumulates at the furrow. Interference with PtdIns(4,5)P2 interferes with adhesion of the plasma membrane to the contractile ring at the furrow. Finally, four distinct interventions to specifically interfere with PtdIns(4,5)P2 each impair cytokinesis. We conclude that PtdIns(4,5)P2 is present at the cleavage furrow and is required for normal cytokinesis at least in part because of a role in adhesion between the contractile ring and the plasma membrane

Intersectionality and equity: Dynamic bureaucratic representation in higher education

Representative bureaucracy scholarship has yet to address two interrelated phenomena: intersectionality and changes in relative disadvantage over time. This manuscript addresses these gaps by assessing representation effects at the intersection of race/ethnicity and sex and in previously, but no longer, disadvantaged client groups. It also argues that if bureaucratic representation is viewed as a quest for equity, then representation will decline as disadvantaged client groups approach equity in policy outcomes. Using panel data for US higher education, this study highlights the importance of intersectional representation in bureaucratic organizations. In three of the four race/ethnic/sex combinations, students perform better in the presence of faculty who match them intersectionally (in the fourth case, race but not sex matters). The empirical results also find that as a formerly disadvantaged client group (women) becomes successful within an organization, the active representation relationship declines. These implications inform future representative bureaucracy scholarship examining intersectional groups

Lipstick and Logarithms: Gender, Institutional Context, and Representative Bureaucracy

According to the theory of representative bureaucracy, passive representation among public employees will lead to active representation in bureaucratic outputs. Existing research demonstrates that the link between passive and active representation exists for race but not for sex. Past research on this topic has not, however, taken into account the contextual environment that affects whether sex will translate into gender and lead to active representation in the bureaucracy. In this paper, we create a framework that specifies the conditions that affect whether passive representation results in active representation for sex and then test this framework using the case of education. We find that passive representation of women in education leads to active representation and that the institutional context affects the extent to which this link between passive and active representation occurs

Assessing Associations Between Individual-Level Social Determinants of Health and COVID-19 Hospitalizations: Investigating Racial/ethnic Disparities Among People Living with Human Immunodeficiency Virus (HIV) in the U.S. National COVID Cohort Collaborativ

Abstract Background: Leveraging the National COVID-19 Cohort Collaborative (N3C), a nationally sampled electronic health records repository, we explored associations between individual-level social determinants of health (SDoH) and COVID-19-related hospitalizations among racialized minority people with human immunodeficiency virus (HIV) (PWH), who have been historically adversely affected by SDoH. Methods: We retrospectively studied PWH and people without HIV (PWoH) using N3C data from January 2020 to November 2023. We evaluated SDoH variables across three domains in the Healthy People 2030 framework: (1) healthcare access, (2) economic stability, and (3) social cohesion with our primary outcome, COVID-19-related hospitalization. We conducted hierarchically nested additive and adjusted mixed-effects logistic regression models, stratifying by HIV status and race/ethnicity groups, accounting for age, sex, comorbidities, and data partners. Results: Our analytic sample included 280,441 individuals from 24 data partner sites, where 3,291 (1.17%) were PWH, with racialized minority PWH having higher proportions of adverse SDoH exposures than racialized minority PWoH. COVID-19-related hospitalizations occurred in 11.23% of all individuals (9.17% among PWH, 11.26% among PWoH). In our initial additive modeling, we observed that all three SDoH domains were significantly associated with hospitalizations, even with progressive adjustments (adjusted odds ratios [aOR] range 1.36–1.97). Subsequently, our HIV-stratified analyses indicated economic instability was associated with hospitalization in both PWH and PWoH (aOR range 1.35–1.48). Lastly, our fully adjusted, race/ethnicity-stratified analysis, indicated access to healthcare issues was associated with hospitalization across various racialized groups (aOR range 1.36–2.00). Conclusion: Our study underscores the importance of assessing individual-level SDoH variables to unravel the complex interplay of these factors for racialized minority groups

Mineral transformation and biomass accumulation associated with uranium bioremediation at

One sentence synopsis: Acetate injection for uranium bioremediation leads to the modification of the porosity of subsurface materials through the accumulation of new mineral phases and biomass

Winter wheat, 1990

"August, 1990.""Publication costs paid by Missouri Seed Improvement Association."Authors: Kenneth D. Kephart, Assistant Professor and State Extension Agronomist-Small Grains; Anne L. McKendry, Assistant Professor and Small Grains Breeder; David N. Tague, Senior Research Laboratory Technician; and James E. Berg, Research Specialist, Department of Agronomy, University of Missouri, Columbia. Calvin L. Hoenshell, Research Specialist, Southwest Missouri Research Center, Mt. Vernon. Roger C. Wilkins, Farm Worker II, Greenley Memorial Center, Novelty.Special Report No. 416 is a contribution of the Department of Agronomy, University of Missouri Agricultural Experiment Station. The Missouri Winter Wheat Performance Testing program is partially funded by Missouri wheat farmers and businessmen through a grant from the Missouri Seed Improvement Association and by fees from companies submitting varieties for evaluation

Statistical methods for building better biomarkers of chronic kidney disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149268/1/sim8091.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149268/2/sim8091_am.pd